Results 121 to 130 of about 539,283 (308)

Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance. [PDF]

, 2019
Circadian clocks control daily rhythms in behavior and physiology. In Drosophila, the small ventral lateral neurons (sLNvs) expressing PIGMENT DISPERSING FACTOR (PDF) are the master pacemaker neurons generating locomotor rhythms.
Cai, Yao, Chiu, Joanna C, Lam, Vu H, Liu, Zhenxing, Mcintire, Pearson, Niu, Ye, Tabuloc, Christine A, Xue, Yongbo, Zhang, Yong   +8 more
core   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

DNA repair synthesis and histone deposition partner during homologous recombination

Molecular & Cellular Oncology, 2018
Chromatin remodeling is critical for the regulation of the DNA damage response. We highlight findings from our recent study showing that the deposition of the histone variant H3.3 by the alpha-thalassemia mental retardation X-linked protein (ATRX) and ...
Amira Elbakry, Szilvia Juhász, Arthur Mathes, Markus Löbrich   +3 more
doaj   +1 more source

Epigenetics and chromatin remodeling play a role in lung disease [PDF]

, 2011
Epigenetics is defined as heritable changes that affect gene expression without altering the DNA sequence. Epigenetic regulation of gene expression is facilitated through different mechanisms such as DNA methylation, histone modifications and RNA ...
Adcock, IM, Barnes, PJ, Masjedi, MR, Mortaz, E   +3 more
core   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source

Editorial: Impact on Embryonic Development of Chromatin Remodeling Alterations [PDF]

, 2021
Cristina Gervasini, Mario García‐Domínguez, Valentina Massa   +2 more
openalex   +1 more source

SIRT7 and p53 interaction in embryonic development and tumorigenesis

Frontiers in Cell and Developmental Biology
p53 is a hallmark tumor suppressor due in part to its role in cell cycle progression, DNA damage repair, and cellular apoptosis; its protein activity interrelates with the Sirtuin family of proteins, major regulators of the cellular response to metabolic,
Berta N. Vazquez, Berta N. Vazquez, Irene Fernández-Duran, Yurdiana Hernandez, Shahriar Tarighi, Joshua K. Thackray, Maria Espinosa-Alcantud, Poonam Kumari, Alessandro Ianni, Alessandro Ianni, Lionel Cesaire, Thomas Braun, Manel Esteller, Manel Esteller, Manel Esteller, Manel Esteller, Jay Tischfield, Alejandro Vaquero, Lourdes Serrano   +18 more
doaj   +1 more source

Deacetylation of ACLY Mediates RNA M6A‐Modification of NOXA and Promotes Chemoresistance of Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the deacetylation of ACLY at K978 acts as a novel risk in colorectal cancer chemoresistance. The deacetylation of K978 induces ACLY relocation to the nucleus and promotes its binding to RBM15, a m6A methylation modification “writer”.
Jun Wen, Mengqin Shen, Haitao Zhao, Liu Liu, Qian Hua, Xiaoping Zhao, Jianjun Liu, Haizhong Feng, Gang Huang   +8 more
wiley   +1 more source

Pathogenic variants inSMARCA5, a chromatin remodeler, cause a range of syndromic neurodevelopmental features [PDF]

, 2020
Dong Li, Qin Wang, Naihua N. Gong, Alina Kurolap, Hagit Baris Feldman, Nikolas Boy, Melanie Brugger, Katheryn Grand, Kirsty McWalter, María J. Guillen Sacoto, Emma Wakeling, Jane A. Hurst, Michael March, Elizabeth Bhoj, Małgorzata J.M. Nowaczyk, Claudia Gonzaga‐Jauregui, Mariam Mathew, Ashita Dava-Wala, Amy Siemon, Dennis Bartholomew, Yue Huang, Hane Lee, Julián A. Martínez-Agosto, Eva Maria Christina Schwaibold, Theresa Brunet, Daniela Choukair, Lynn Pais, Susan M. White, John Christodoulou, Dana Brown, Kristin Lindstrom, Theresa A. Grebe, Dov Tiosano, Matthew S. Kayser, Tiong Yang Tan, Matthew A. Deardorff, Yuanquan Song, Hákon Hákonarson   +37 more
openalex   +1 more source

Chromatin remodeling complexes: architects influencing breast cancer progression

Frontiers in Cell and Developmental Biology
As one of the most common types of cancer, breast cancer strongly contributes to the increase in morbidity and mortality worldwide. Alterations in the genetic and epigenetic landscape contribute to the complexity and heterogeneity of the disease, making ...
Octavianus Giovani, Grace S. Eckersley, Hayden R. Jones, Sankari Nagarajan   +3 more
doaj   +1 more source