Results 121 to 130 of about 578,337 (355)
Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication
Advanced Science, EarlyView.EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen +12 morewiley +1 more sourceNDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease
Advanced Science, EarlyView.NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo +18 morewiley +1 more sourceGENE-16. CLINICALLY AGGRESSIVE MENINGIOMAS ARE CHARACTERIZED BY MUTATIONAL SIGNATURES ASSOCIATED WITH DEFECTIVE DNA REPAIR AND MUTATIONS IN CHROMATIN REMODELING GENES [PDF]
, 2018 Sylvia C. Kurz, Benjamin Liechty, Stephen Kelly, Varshini Vasudevaraja, Ramona Bledea, Peter Wu, Jonathan Serrano, Leah Katz, Joshua S. Silverman, Donato Pacione, John G. Golfinos, Andrew Chi, Matija Snuderl +12 moreopenalex +1 more sourceData Supplement from SNF5/INI1 Deficiency Redefines Chromatin Remodeling Complex Composition during Tumor Development
, 2023 Darmood Wei, Dennis Goldfarb, Shujie Song, Courtney Cannon, Feng Yan, Donastas Sakellariou-Thompson, Michael J. Emanuele, Michael B. Major, Bernard E. Weissman, Yasumichi Kuwahara +9 moreopenalex +1 more sourceChromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton
Advanced Science, EarlyView.This study investigates cotton’s high‐temperature (HT) response using multi‑omics. Dynamic 3D genome changes drive expression bias affecting male fertility. The tolerant line shows controlled chromatin dynamics, while the sensitive line exhibits overactivation.Yanlong Li, Jing Yang, Weiran Wang, Chunyang Zuo, Liuling Pei, Yizan Ma, Rui Zhang, Yaru Fan, Huanhuan Ma, Yawei Li, Ruizhen Liu, Shuangxia Jin, Longfu Zhu, Jie Kong, Xianlong Zhang, Ling Min +15 morewiley +1 more sourceData from SNF5/INI1 Deficiency Redefines Chromatin Remodeling Complex Composition during Tumor Development
, 2023 Darmood Wei, Dennis Goldfarb, Shujie Song, Courtney Cannon, Feng Yan, Donastas Sakellariou-Thompson, Michael J. Emanuele, Michael B. Major, Bernard E. Weissman, Yasumichi Kuwahara +9 moreopenalex +1 more sourceStructural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program [PDF]
, 2022 Carlos Jiménez, Roberta Antonelli, Mariona Nadal‐Ribelles, Laura Devis, Pablo Latorre, Carme Solé, Marc Masanas, Adrià Molero-Valenzuela, Aroa Soriano, Joan Sánchez-de-Toledo, David Llobet‐Navàs, Josep Roma, Francesc Posas, Eulàlia de Nadal, Soledad Gallego, Lucas Moreno, Miguel F. Segura +16 moreopenalex +1 more sourceCancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression
Advanced Science, EarlyView.Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang +12 morewiley +1 more sourceSupplementary Tables from The Discovery of SWI/SNF Chromatin Remodeling Activity as a Novel and Targetable Dependency in Uveal Melanoma
, 2023 Florencia Rago, GiNell Elliott, Ailing Li, Kathleen Sprouffske, Gráinne Kerr, Aurore Desplat, Dorothée Abramowski, Julie Chen, Ali Farsidjani, Kay X. Xiang, Geoffrey Bushold, Yun Feng, Matthew D. Shirley, Anka Bric, Anthony Vattay, Henrik Möbitz, Katsumasa Nakajima, Christopher D. Adair, Simon Mathieu, Rukundo Ntaganda, Troy A. Smith, Julien P. N. Papillon, Audrey Kauffmann, David A. Ruddy, Hyo‐eun C. Bhang, Deborah Castelletti, Zainab Jagani +26 moreopenalex +1 more source
