Results 111 to 120 of about 199,504 (302)
Advanced Healthcare Materials, EarlyView.A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang +12 more
wiley +1 more source
Nature CommunicationsSwitch defective/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are multi-subunit machineries that establish and maintain chromatin accessibility and gene expression by regulating chromatin structure.
Yawen Lei +11 more
doaj +1 more source
Activation of gene expression by histone deubiquitinase OTLD1
Epigenetics, 2017 One of the main mechanisms of epigenetic control is post translational modification of histones, and one of the relatively less characterized, yet functionally important histone modifications is monoubiquitylation, which is reversed by histone ...
Ido Keren, Vitaly Citovsky
doaj +1 more source
Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. [PDF]
, 2015 Mouse embryonic stem cells (ESCs) are genetically more stable than somatic cells, thereby preventing the passage of genomic abnormalities to their derivatives including germ cells. The underlying mechanisms, however, remain largely unclear. In this paper,
Briggs, Steven P +7 more
core
Advanced Healthcare Materials, EarlyView.Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram +10 more
wiley +1 more source
Human chromatin remodelers regulating HIV-1 transcription: a target for small molecule inhibitors
Epigenetics & ChromatinHIV-1 can establish a lifelong infection by incorporating its proviral DNA into the host genome. Once integrated, the virus can either remain dormant or start active transcription, a process governed by the HIV Tat protein, host transcription factors and
Yuan Ma, Chuan Li, Susana Valente
doaj +1 more source
ATP-dependent Remodeling of Chromatin
Cold Spring Harbor Symposia on Quantitative Biology, 1998 Peer ...
Wu, Carl +8 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens +3 more
wiley +1 more source
Mutation in DDM1 inhibits the homology directed repair of double strand breaks.
PLoS ONE, 2019 In all organisms, DNA damage must be repaired quickly and properly, as it can be lethal for cells. Because eukaryotic DNA is packaged into nucleosomes, the structural units of chromatin, chromatin modification is necessary during DNA damage repair and is
Seung Hee Choi +5 more
doaj +1 more source
Dietary polyphenols and chromatin remodeling
Critical Reviews in Food Science and Nutrition, 2017 Polyphenols are the most abundant phytochemicals in fruits, vegetables, and plant-derived beverages. Recent findings suggest that polyphenols display the ability to reverse adverse epigenetic regulation involved in pathological conditions, such as obesity, metabolic disorder, cardiovascular and neurodegenerative diseases, and various forms of cancer ...
Gian Luigi Russo +5 more
openaire +5 more sources