Results 141 to 150 of about 539,283 (308)

Sympathetic Activation Promotes Kidney Fibrosis in Mice via Macrophage‐Derived N2ICD‐Enriched Extracellular Vesicles

Advanced Science, EarlyView.
Norepinephrine/α2B‐adrenoceptor axis promotes the secretion of Notch2 intracellular domain (N2ICD)‐enriched extracellular vesicles (EVs) from macrophages. These EVs deliver N2ICD into fibroblasts, thereby inducing their activation. Deletion of Notch2 or α2B‐AR in macrophages disrupts N2ICD‐enriched EV formation and alleviates kidney fibrosis in mice ...
Huiwen Ren, Yayan Hou, Chengsen Mu, Yinghong Zheng, Yuanyang Wang, Shumin Guo, Lu Wang, Wenlong Shang, Zhuming Yin, Cheng Dong, Yongsheng Chang, Bin Zhou, Renjie Chai, Ying Yu, Yujun Shen   +14 more
wiley   +1 more source

Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture. [PDF]

, 2018
Epigenetic processes are known to have powerful roles in organ development across biology. It has recently been found that some of the chromatin modulatory machinery essential for proper development plays a previously unappreciated role in the ...
McKinsey, Timothy A, Vondriska, Thomas M, Wang, Yibin   +2 more
core  

Restoring Histone Acetylation Accelerates Diabetic Wound Repair by Improving the Spatiotemporal Dynamics of Macrophages

Advanced Science, EarlyView.
Butyrate—via epigenetic modulation of the histone core—rebalance dysregulated macrophage function and promotes wound healing under persisting hostile conditions of diabetic mice. Additionally, butyrate harmonizes macrophage interactions with keratinocytes and fibroblasts as well as breaks the vicious cycle of inflammation in chronic wounds by restoring
Karmveer Singh, Albert Kallon Koroma, Rajeev Kumar Pandey, Yongfang Wang, Jinnan Cheng, Philipp Haas, Mahyar Aghapour, Linda Krug, Adelheid Hainzl, Meinhard Wlaschek, Pallab Maity, Karin Scharffetter‐Kochanek   +11 more
wiley   +1 more source

Supplementary Tables from The Discovery of SWI/SNF Chromatin Remodeling Activity as a Novel and Targetable Dependency in Uveal Melanoma

, 2023
Florencia Rago, GiNell Elliott, Ailing Li, Kathleen Sprouffske, Gráinne Kerr, Aurore Desplat, Dorothée Abramowski, Julie Chen, Ali Farsidjani, Kay X. Xiang, Geoffrey Bushold, Yun Feng, Matthew D. Shirley, Anka Bric, Anthony Vattay, Henrik Möbitz, Katsumasa Nakajima, Christopher D. Adair, Simon Mathieu, Rukundo Ntaganda, Troy A. Smith, Julien P. N. Papillon, Audrey Kauffmann, David A. Ruddy, Hyo‐eun C. Bhang, Deborah Castelletti, Zainab Jagani   +26 more
openalex   +1 more source

CircSMEK1 Suppresses HCC via the hnRNPK‐IGF2‐AKT Axis: A Diagnostic Biomarker and Therapeutic Target

Advanced Science, EarlyView.
CircSMEK1 is downregulated in MASH/HCC and predicts poor prognosis. It suppresses tumor progression by promoting hnRNPK ubiquitination and inhibiting the IGF2/PI3K/AKT axis, while its loss activates immunosuppressive cancer‐associated fibroblasts. Serum circSMEK1 serves as a non‐invasive diagnostic biomarker, and its restoration potently inhibits HCC ...
Peilan Guo, Xiaomeng Jia, Shenghong Wang, Xinyu Li, Yajing Liu, Lisen Lin, Zhengkun Wang, Fujun Liu, Slawomir Wolczynski, Nafis Rahman, Jie Gao, Xuguang Du, Suk‐Ying Tsang, Jiali Liu, Wei Song, Xiangdong Li   +15 more
wiley   +1 more source

p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells [PDF]

, 2013
Andrei N. Mardaryev, Michał R. Gdula, Joanne L. Yarker, Vladimir U. Emelianov, Krzysztof Poterlowicz, Andrey A. Sharov, Tatyana Sharova, Julie A. Scarpa, Pierre Chambon, Vladimir A. Botchkarev, Michael Y. Fessing   +10 more
openalex   +1 more source

Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies.

Trends in Genetics, 2020
Richard C. Centore, Gabriel J. Sandoval, L. M. Soares, Cigall Kadoch, H. Chan   +4 more
semanticscholar   +1 more source

Hypoxia‐Induced circPRELID2 Promotes Gastric Cancer Metastasis by Facilitating ZEB2 Translation via PCBP1 O‐GlcNAcylation

Advanced Science, EarlyView.
Under hypoxia, HIF1A is directly bound to the PRELID2 promoter to increase PRELID2 pre‐mRNA expression, followed by the DYRK1A–SFPQ–SAM68 complex binding to Alu‐containing introns in PRELID2 pre‐mRNA, leading to circPRELID2 circularization. CircPRELID2 interacts with PCBP1 and promotes its cytoplasmic retention.
Pengshan Zhang, Zai Luo, Yitian Xu, Yuan Zhang, Renchao Zhang, Nadina Paerhati, Shaopeng Zhang, Qianqian Cai, Zhengjun Qiu, Chen Huang   +9 more
wiley   +1 more source

Gut Microbial Genetic Variation Prolongs Host Healthy Longevity and Remodels Metabolome and Proteome in Drosophila Melanogaster

Advanced Science, EarlyView.
This study reveals that specific genetic variations in gut‐residing Saccharomyces cerevisiae significantly extend healthspan and lifespan in Drosophila melanogaster. These mutants rejuvenate aged intestinal metabolism, upregulate mitochondrial proteins, and enhance energy pathways.
Liying Wang, Ziling Yang, Yulu Pang, Xinyue Wu, Xinrong Zhang, Tao Zhu, Xiaoyue Ding, Wei Liu, Yuan Zhou, Pengcheng Zhang, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Chromatin remodeler HELLS maintains glioma stem cells through E2F3 and MYC [PDF]

, 2019
Guoxin Zhang, Zhen Dong, Briana C. Prager, Leo J.Y. Kim, Qiulian Wu, Ryan C. Gimple, Xiuxing Wang, Shideng Bao, Petra Hamerlik, Jeremy N. Rich   +9 more
openalex   +1 more source