Results 161 to 170 of about 539,283 (308)

An overproduction of astellolides induced by genetic disruption of chromatin-remodeling factors in Aspergillus oryzae [PDF]

, 2015
Yasutomo Shinohara, Makoto Kawatani, Yushi Futamura, Hiroyuki Osada, Yasuji Koyama   +4 more
openalex   +1 more source

METTL10‐Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression

Advanced Science, EarlyView.
METTL10‐mediated methylation of PIAS3 at K442 inhibits its SUMO E3 ligase activity toward MITF. This reduces MITF SUMOylation and subsequent RNF4‐mediated ubiquitination, leading to MITF protein accumulation and gastric cancer progression. Abstract Metabolic dysregulation plays a significant role in the development of gastric cancer (GC).
Jinshui Tan, Huiwen Zhou, Jingsong Ma, Chensong Zhang, Yuhua Tan, Baoding Zhang, Jiabao Zhao, Ao Cheng, Chengyu Yang, Meijuan Xu, Shengyi Zhou, Yubo Xiong, Zeyang Lin, Guangchao Pan, Wenjie Ye, Mengya Zhong, Yang Yang, Yifan Zhuang, Shao‐Wei Li, Xianming Deng, Xuehui Hong   +20 more
wiley   +1 more source

Chromatin Remodeling and Transcriptional Silencing Define the Dynamic Innate Immune Response of Tissue Resident Macrophages After Burn Injury [PDF]

Han Sang Kim, Marie‐Pierre L. Gauthier, Aidan Higgs, Denise A. Hernandez, Mingqi Zhou, Jason O. Brant, Rhonda Bacher, Dijoia B. Darden, Shannon M. Wallet, Clayton E. Mathews, Philip A. Efron, Michael P. Kladde, Robert Maile   +12 more
openalex   +1 more source

Variations in flanking or less conserved positions of Reb1 and Abf1 consensus binding sites lead to major changes in their ability to modulate nucleosome sliding activity

Biological Research
Background Maintenance of nucleosome-free regions at gene regulatory regions conform a relevant aspect within chromatin dynamics. In the yeast Saccharomyces cerevisiae, Reb1 and Abf1 are among the transcriptions factors that perform this molecular ...
Fernanda Raiqueo, Roberto Amigo, José L. Gutiérrez   +2 more
doaj   +1 more source

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

The chromatin remodeling factor Arid1a cooperates with Jun/Fos to promote osteoclastogenesis by epigenetically upregulating Siglec15 expression [PDF]

Yongxing Zhang, Hangxiang Sun, Fei Huang, Yang Chen, Xiying Ding, Chenhe Zhou, Yan Wu, Qing Zhang, Xiao Ma, Jun Wang, Rui Yue, Li Shen, Xuxu Sun, Zhaoming Ye   +13 more
openalex   +1 more source

PM2.5 Induce Endothelial‐Mesenchymal Transition and Cardiac Fibrosis via the NCOA4‐Mediated Ferritinophagy

Advanced Science, EarlyView.
This study primarily reveals that PM2.5‐derived Fe‐containing particles, particularly magnetite, are specifically enriched in the heart. Here, they interact with NCOA4 in endothelial cells, disrupt iron homeostasis by enhancing ferritinophagy, and subsequently trigger the process of EndMT through the NCOA4/KLF5 pathway.
Qinglin Sun, Mengyuan Wang, Lin Liu, Ruiyang Ding, Kanglin Yan, Shiqian Liu, Xiaoke Ren, Qing Xu, Zhiwei Sun, Qian Liu, Yi Yang, Junchao Duan   +11 more
wiley   +1 more source

GENE-16. CLINICALLY AGGRESSIVE MENINGIOMAS ARE CHARACTERIZED BY MUTATIONAL SIGNATURES ASSOCIATED WITH DEFECTIVE DNA REPAIR AND MUTATIONS IN CHROMATIN REMODELING GENES [PDF]

, 2018
Sylvia C. Kurz, Benjamin Liechty, Stephen Kelly, Varshini Vasudevaraja, Ramona Bledea, Peter Wu, Jonathan Serrano, Leah Katz, Joshua S. Silverman, Donato Pacione, John G. Golfinos, Andrew Chi, Matija Snuderl   +12 more
openalex   +1 more source

BHLHE40 Cooperates with GATA2/3 to Control Human Syncytiotrophoblast Lineage Differentiation

Advanced Science, EarlyView.
BHLHE40 interacts directly with GATA2 and GATA3 and co‐occupies genomic loci critical for STB differentiation and function. BHLHE40 also affects GATA2/3 binding at enhancer and promoter regions. Moreover, BHLHE40 is potentially involved in genome‐wide remodeling of H3K4me3 and H3K27ac chromatin landscapes through GATA2/3 recruitment, activating ...
Lijin Peng, Weijie Zhao, Chunfang Xu, Yue Li, Jiani Guo, Taotao Zhou, Philip Chiu, Huimei Wu, Qingyu Wu, Yanxing Wei, Shaorong Gao, Meirong Du   +11 more
wiley   +1 more source

Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer

Advanced Science, EarlyView.
An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou, Cheng‐Wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley M. Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro E. Gerges, Mason D. Flores, Han Li, Li‐Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel J. McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng   +30 more
wiley   +1 more source