Results 231 to 240 of about 578,337 (355)

EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets

Advanced Science, EarlyView.
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang, Fujun Hou, Xunuo Jin, Yuhang Xiang, Dongli Pan   +4 more
wiley   +1 more source

HDACs in the Brain: From Chromatin Remodeling to Neurodegenerative Disease. [PDF]

Cells
Diniz LP, Pinheiro PSM, Franco LS, Gomes FCA.   +3 more
europepmc   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Co-condensation between transcription factor and cBAF selectively modulates chromatin remodeling and gene expression. [PDF]

Nat Commun
Ye X, Xu L, Sun X, Gai Y, Yang H, Sun Q, Song J, Huang P, Zhou Q, Li Y, Li N, Jin J, Li Y, Rao W, Lu H, Wang P, Chang C, Lu Y.   +17 more
europepmc   +1 more source

SWI/SNF chromatin remodeling and human malignancies.

Annual Review of Pathology, 2015
J. Masliah-Planchon, I. Bièche, J. Guinebretière, F. Bourdeaut, O. Delattre   +4 more
semanticscholar   +1 more source

Elevator‐Like Hollow Channels in Porous Scaffolds Accelerate Vascularized Bone Regeneration via NETs‐Fibrin‐Mediated Macrophage Recruitment

Advanced Science, EarlyView.
This study demonstrates that how hollow‐channel scaffolds promote vascularized bone regeneration via an immunomodulatory mechanism. The channel structures facilitate the formation of a neutrophil extracellular traps‐fibrin scaffold that recruits vascular endothelial growth factor A (VEGF‐A)‐secreting M2 macrophages to drive angiogenesis. Combining this
Guifang Wang, Rongpu Liu, Huijing Ma, Shuhan Duan, Guangzheng Yang, LingXi Meng, Yuqin Qiao, Dongqiang Song, Wenjie Zhang   +8 more
wiley   +1 more source

TRIM24 regulates chromatin remodeling and calcium dynamics in cardiomyocytes. [PDF]

Cell Commun Signal
Neu M, Deshpande A, Borlepawar A, Hammer E, Alameldeen A, Vöcking P, Seeger T, Hausmann M, Frey N, Rangrez AY.   +9 more
europepmc   +1 more source

Dual Chromatin and Cytoskeletal Remodeling by SETD2

Cell, 2016
I. Park, Reid T Powell, D. Tripathi, R. Dere, T. Ho, T. Blasius, Yun-Chen J Chiang, I. Davis, Catherine C Fahey, K. Hacker, K. Verhey, M. Bedford, E. Jonasch, W. Rathmell, C. Walker   +14 more
semanticscholar   +1 more source

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, EarlyView.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

HDAC2-mediated chromatin remodeling drives hepatocellular carcinoma progression: an integrative analysis of computational pathology and multi-transcriptomics. [PDF]

J Transl Med
Yin S, Zhou X, Jiang L, Gu Y, Dai J, Chen H, Zhang S, Lu J, Huang G, Jiang Y, Sang X, Yuan K, Yang H, Yang G, Huang S, Chi H, Xu K.   +16 more
europepmc   +1 more source