Results 241 to 250 of about 199,504 (302)

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Advanced Science, EarlyView.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan, Yelian Yan, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang, Chao Liu, Tao Huang, Keliang Wu   +8 more
wiley   +1 more source

Chromatin remodeling enhances MAP3K8 expression in HAM: a key pathogenesis for therapeutic intervention. [PDF]

Nat Commun
Nakashima M, Nagai K, Takao N, Araya N, Kuze Y, Mizuike J, Tosaka S, Aratani S, Yagishita N, Horibe E, Watanabe T, Sato T, Nannya Y, Suzuki Y, Uchimaru K, Yamagishi M, Yamano Y.   +16 more
europepmc   +1 more source

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

When BRG1 Turns Off: Chromatin Remodeling and YAP Signaling Drive ITPN Progression. [PDF]

Cell Mol Gastroenterol Hepatol
Takano S, Ohtsuka M.
europepmc   +1 more source

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Chromatin remodeling activity of EP400 safeguards chromosomal stability by preventing CENP-A mislocalization. [PDF]

Cell Rep
Sethi SC, Shrestha RL, Balachandra V, Hori T, Corda L, Lin S, Ozbun L, Karpova TS, McKinnon K, Chari R, Pegoraro G, Cheng KC, Giunta S, Caplen NJ, Fukagawa T, Basrai MA.   +15 more
europepmc   +1 more source

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, EarlyView.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source

BPTF-665aa mediate chromatin remodeling drives chemoresistance in T-LBL/ALL. [PDF]

J Exp Clin Cancer Res
Chen RH, Li M, Zhou ZZ, Fang XJ, Zhu Y, Zhang Y, Liu X, Li HL, Feng J, Song LY, Yu RM, Gao TX, Tian XP, Huang WJ.   +13 more
europepmc   +1 more source

Peripheral chromatin remodeling at the center of zygotic genome activation. [PDF]

Cell Genom
de Chancel L, Maître JL.
europepmc   +1 more source