Results 251 to 260 of about 578,337 (355)

ATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex

Science, 2004
G. Mizuguchi, Xuetong Shen, Joseph Landry, Wei-Hua Wu, S. Sen, Carl Wu   +5 more
semanticscholar   +1 more source

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

Chromatin remodeling and H3K4me3 depletion regulate germline specification from pluripotency. [PDF]

Stem Cell Res Ther
Wang S, Meng L, Huang X, Peng Z, Hua Y, Liao Y, Ren R, Wang H, Zhu G.   +8 more
europepmc   +1 more source

Author response: The chromatin remodelers RSC and ISW1 display functional and chromatin-based promoter antagonism

, 2015
Timothy J. Parnell, Alisha Schlichter, Boris G. Wilson, Bradley R. Cairns   +3 more
openalex   +1 more source

Chromatin remodeling and bivalent histone modifications in embryonic stem cells

EMBO Reports, 2015
Arigela Harikumar, E. Meshorer
semanticscholar   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Endothelial cells retain inflammatory memory through chromatin remodeling in a two-hit model of infection-induced inflammation. [PDF]

Am J Physiol Cell Physiol
Gonsales Spindola D, Bahr A, Clark S, Pin de Jesus G, Martino N, Lowery A, Lyu S, Seeman A, Martino G, Albeche Duarte G, Crosbourne E, Vincent P, Bai G, Adam AP, MacNamara KC, Bossardi Ramos R.   +15 more
europepmc   +1 more source

Roles and activities of chromatin remodeling ATPases in plants.

The Plant Journal, 2015
Soon-Ki Han, Miin-Feng Wu, Sujuan Cui, D. Wagner   +3 more
semanticscholar   +1 more source

DR5 Governs Compound Exocytosis in Colonic Goblet Cells via TATA‐Box Binding Protein‐Dependent Bestrophin‐2 Transcriptional Regulation

Advanced Science, EarlyView.
DR5 knockout exhibits a thinner colonic mucus layer, leading to mild dysbiosis, increased susceptibility to Citrobacter rodentium invasion, and exacerbated epithelial injury. Mechanistically, DR5 binds transcription factor TBP, which regulates the expression of gene Best2 via its promoter.
Ying Wang, Xinyun Li, Yong Wang, Chuhe Yang, Xiaopei Gao, Ke Zhu, Yihang Ren, Jingxin Li, Chuanyong Liu, Bing Xue   +9 more
wiley   +1 more source