Results 281 to 290 of about 680,917 (346)

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Scaffolding of the H4K5ac chromatin remodeling complex by lncRNA MAHAC mediates epithelial-mesenchymal transition. [PDF]

Nucleic Acids Res
Hsu KW, Chang JS, Lai JC, Yang LH, Peng PH, Lin TC, Wu KJ.   +6 more
europepmc   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling. [PDF]

Nat Commun
Liu X, Ye Y, Li Z, Liao L, Wei Q.
europepmc   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Cooperation of Transcription Factor PAX6 with Chromatin-Remodeling Complex BAF During Embryonic Development in Mammals. [PDF]

Cell Mol Neurobiol
Azieva A, Vasilyeva T, Maksimenko O, Davydenko K, Zinchenko R, Marakhonov A.   +5 more
europepmc   +1 more source

The PBAF chromatin remodeling complex contributes to metal homeostasis through MTF1 regulation. [PDF]

Metallomics
Carulli N, Johnston EE, Klein DC, Verdejo-Torres O, Parikh A, McDaniels A, Rivera A, Quinteros M, Pezacki AT, Chang CJ, Hainer SJ, Padilla-Benavides T.   +11 more
europepmc   +1 more source

SLC25A3 promotes hepatocellular carcinoma progression by inducing mitochondrial dysfunction and chromatin remodeling. [PDF]

Transl Cancer Res
Deng S, Fu J.
europepmc   +1 more source

Punicalagin with anti-inflammatory activities affects Brd-4 mediated chromatin remodeling for attenuating inflammatory osteolysis. [PDF]

Sci Rep
Li H, Li Q, Wan T, Wang Y, Zhang S.
europepmc   +1 more source

Noncanonical association of EZH2 with E2F1 promotes tumor proliferation through chromatin remodeling. [PDF]

Exp Mol Med
Yoo M, Lee H, Park H, Kang B, Kim HM, Kim TK, Roh TY.   +6 more
europepmc   +1 more source