Results 51 to 60 of about 182,469 (300)
Localization of the Chromatin Remodelling Protein, ATRX in the Adult Testis
Journal of Reproduction and Development, 2011 Mutations in ATRX (alpha-thalassaemia and mental retardation on the X-chromosome) can give rise to ambiguous or female genitalia in XY males, implying a role for ATRX in testicular development. Studies on ATRX have mainly focused on its crucial role in brain development and α-globin regulation; however, little is known about its function in sexual ...
Tang, Paisu +6 more
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Transcriptional Regulation: a Genomic Overview [PDF]
, 2002 The availability of the Arabidopsis thaliana genome sequence allows a comprehensive analysis of transcriptional regulation in plants using novel genomic approaches and methodologies. Such a genomic view of transcription first necessitates the compilation
Riechmann, José Luis
core +2 more sources
Role of protein methylation in chromatin remodeling and transcriptional regulation [PDF]
Oncogene, 2001 Recent findings suggest that lysine and arginine-specific methylation of histones may cooperate with other types of post-translational histone modification to regulate chromatin structure and gene transcription. Proteins that methylate histones on arginine residues can collaborate with other coactivators to enhance the activity of specific ...
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Rad51 polymerization reveals a new chromatin remodeling mechanism. [PDF]
PLoS ONE, 2008 Rad51 protein is a well known protagonist of homologous recombination in eukaryotic cells. Rad51 polymerization on single-stranded DNA and its role in presynaptic filament formation have been extensively documented.
Pauline Dupaigne +7 more
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Cells, 2022 The induction of lineage-specific gene programs are strongly influenced by alterations in local chromatin architecture. However, key players that impact this genome reorganization remain largely unknown. Here, we report that the removal of the special AT-
Ryan A. V. Bell +9 more
doaj +1 more source
Plant chromatin – epigenetics linked to ATP‐dependent remodeling and architectural proteins [PDF]
FEBS Letters, 2004 Studies in organisms belonging to different eukaryotic kingdoms have revealed that the structural state of chromatin is controlled by interactions of DNA, small RNAs and specific proteins, linked to a self‐reinforcing complex network of biochemical activities involving histone and DNA modifications and ATP‐dependent nucleosome remodeling.
Brzeski, Jan, Jerzmanowski, Andrzej
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, 2018 Background: The chromatin remodelers of the SWI/SNF family are critical transcriptional regulators. Recognition of lysine acetylation through a bromodomain (BRD) component is key to SWI/SNF function; in most eukaryotes, this function is attributed to ...
Burtch, Alyson +9 more
core +1 more source
Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. [PDF]
, 2017 ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is frequently mutated in cancer. Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation.
Amaral, Maria Luisa +5 more
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Non-mammalian model organisms in epigenetic research : an overview [PDF]
, 2020 Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation.
Baruah, Sri Kartik +3 more
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Basis of Specificity for a Conserved and Promiscuous Chromatin Remodeling Protein [PDF]
, 2020 Abstract Eukaryotic genomes are organized dynamically through the repositioning of nucleosomes. Isw2 is an enzyme that has been previously defined as a genome-wide, non-specific nucleosome spacing factor. Here, we show that Isw2 instead acts as an obligately targeted nucleosome remodeler in vivo
Drake A. Donovan +7 more
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