Results 71 to 80 of about 182,469 (300)

Human chromatin remodelers regulating HIV-1 transcription: a target for small molecule inhibitors

Epigenetics & Chromatin
HIV-1 can establish a lifelong infection by incorporating its proviral DNA into the host genome. Once integrated, the virus can either remain dormant or start active transcription, a process governed by the HIV Tat protein, host transcription factors and
Yuan Ma, Chuan Li, Susana Valente
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy

JCI Insight, 2022
Ca2+ is critical for cardiac electrical conduction and contractility, and aberrant Ca2+ homeostasis causes arrhythmia and heart failure. Chromatin remodeling modulates gene expression involved in cardiac sarcomere assembly and postnatal heart function ...
Yingchao Shi, Wenli Fan, Mingjie Xu, Xinhua Lin, Wukui Zhao, Zhongzhou Yang   +5 more
doaj   +1 more source

Divergent evolution of CHD3 proteins resulted in MOM1 refining epigenetic control in vascular plants. [PDF]

PLoS Genetics, 2008
Arabidopsis MOM1 is required for the heritable maintenance of transcriptional gene silencing (TGS). Unlike many other silencing factors, depletion of MOM1 evokes transcription at selected loci without major changes in DNA methylation or histone ...
Marian Caikovski, Chotika Yokthongwattana, Yoshiki Habu, Taisuke Nishimura, Olivier Mathieu, Jerzy Paszkowski   +5 more
doaj   +1 more source

TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization [PDF]

, 2015
The ends of eukaryotic chromosomes need to be protected from the activation of a DNA damage response that leads the cell to replicative senescence or apoptosis.
Alicata, Claudia, Cacchione, Stefano, Cicconi, Alessandro, Galati, Alessandra, Gilson, Eric, Giraud Panis, Marie Josèphe, Ingegnere, Tiziano, Micheli, Emanuela, Pusch, Miriam Caroline   +8 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer. [PDF]

PLoS ONE, 2011
Change in gene expression associated with pancreatic cancer could be attributed to the variation in histone posttranslational modifications leading to subsequent remodeling of the chromatin template during transcription.
Parama Dey, Moorthy P Ponnusamy, Shonali Deb, Surinder K Batra   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Chromatin remodeling-driven autophagy activation induces cisplatin resistance in oral squamous cell carcinoma

Cell Death and Disease
It is still challenging to predict the efficacy of cisplatin-based therapy, particularly in relation to the activation of macroautophagy/autophagy in oral squamous cell carcinoma (OSCC). We studied the effect of selected chromatin remodeling genes on the
Su Young Oh, Jinkyung Kim, Kah Young Lee, Heon-Jin Lee, Tae-Geon Kwon, Jin-Wook Kim, Sung-Tak Lee, Dae-Geon Kim, So-Young Choi, Su-Hyung Hong   +9 more
doaj   +1 more source

Baf45a Mediated Chromatin Remodeling Promotes Transcriptional Activation for Osteogenesis and Odontogenesis

Frontiers in Endocrinology, 2022
Chromatin remodeling, specifically the tissue-specific regulation in mineralized tissues, is an understudied avenue of gene regulation. Here we show that Baf45a and Baf45d, two Baf45 homologs belong to ATPase-dependent SWI/SNF chromatin remodeling ...
Theodore Busby, Yuechuan Chen, Tanner C. Godfrey, Mohammad Rehan, Benjamin J. Wildman, Caris M. Smith, Quamarul Hassan   +6 more
doaj   +1 more source