Results 201 to 210 of about 297,526 (265)

Integrated Biomimetic 2D-LC and Permeapad^® Assay for Profiling the Transdermal Diffusion of Pharmaceutical Compounds. [PDF]

Molecules
Neri I, Stevens C, Russo G, Grumetto L.
europepmc   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Reconstitution of glycan-driven MHC I recycling reveals calreticulin as mediator between TAPBPR and tapasin

Heinke TJ, Fahim A, Popovic N, Rath T, Morgner N, Trowitzsch S, Tampé R.   +6 more
europepmc   +1 more source

Structure-guided design of antibody CDRs to reduce their reactivity to treatment-emergent anti-drug antibodies. [PDF]

MAbs
Johansson MU, Kerschenmeyer A, Carella A, Carnal S, Schmidt Y, de Felice A, Mahler D, Thomas M, Spiga FM, Tietz J, Weinert C, Hess C, Urech D, Warmuth S.   +13 more
europepmc   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

LRP1 Interacts with the Rift Valley Fever Virus Glycoprotein Gn via a Calcium-Dependent Multivalent Electrostatic Mechanism. [PDF]

Biomolecules
Yang H, Chen H, Jiang W, Yan R.
europepmc   +1 more source

Screening of a Combinatorial Library of Triazine-Scaffolded Dipeptide-Mimic Affinity Ligands to Bind Plasmid DNA. [PDF]

Molecules
Belchior JFR, Monteiro GA, Prazeres DM, Taipa MÂ.   +3 more
europepmc   +1 more source

Structural mechanisms and insights on multiple nanobodies binding diverse SOD1 epitopes. [PDF]

Commun Biol
Cheng S, Zhong C, Zhu H, Mu K, Jiang H, Zhong P, Ma Z, Liu X, Wang Z, Liu R, Ding Y.   +10 more
europepmc   +1 more source

Impact of Host Cell DNA and Chromatin on Virus-like Particle Analysis by Light Scattering in Asymmetrical Flow Field-flow Fractionation. [PDF]

J Sep Sci
Bacher J, Jakob LA, Mesurado T, Lali N, Zollner A, Jungbauer A, Pereira Aguilar P.   +6 more
europepmc   +1 more source

A novel and rapid method to purify the human complement opsonin C3b from human plasma. [PDF]

Front Immunol
Sichau J, Schmidt CQ.
europepmc   +1 more source