Results 11 to 20 of about 959,191 (335)

A Novel LC–MS/MS-Based Method for the Diagnosis of ADA2 Deficiency from Dried Plasma Spot

Molecules, 2021
Adenosine Deaminase 2 Deficiency (DADA2) (OMIM: 607575) is a monogenic, autoinflammatory disease caused by the loss of functional homozygous or heterozygous mutations in the ADA 2 gene (previously CECR1, Cat Eye Syndrome Chromosome Region 1).
Alessia Cafaro, Federica Pigliasco, Sebastiano Barco, Federica Penco, Francesca Schena, Roberta Caorsi, Stefano Volpi, Gino Tripodi, Marco Gattorno, Giuliana Cangemi   +9 more
doaj   +1 more source

Abnormal retention of s-triazine herbicides on porous graphitic carbon

Reviews in Analytical Chemistry, 2021
Porous graphitic carbon (PGC) is a widely used stationary phase for reversed-phase high-performance liquid chromatography (HPLC) that allows separation of structurally similar compounds retained in mixed form on a flat graphite surface. Such a stationary
Grinevich Oksana, Khesina Zoya, Buryak Alexey   +2 more
doaj   +1 more source

Development and Validation of a Novel LC-MS/MS Method for a TDM-Guided Personalization of HSCT Conditioning with High-Dose Busulfan in Children

Biomedicines, 2023
Personalization of busulfan (Bu) exposure via therapeutic drug monitoring (TDM) is recommended for patients treated with high-dose conditioning regimens.
Alessia Cafaro, Federica Pigliasco, Giammarco Baiardi, Sebastiano Barco, Manuela Stella, Roberto Bandettini, Francesca Mattioli, Maura Faraci, Giuliana Cangemi   +8 more
doaj   +1 more source

Early gas chromatography/mass spectrometry [PDF]

Journal of the American Society for Mass Spectrometry, 1993
Spectroscopy Laboratory, The Dow Chemical Company, Midland, Michigan, USA In December 1955 or thereabouts, the authors coupled a homemade gas chromatograph to a research time-of-flight mass spectrometer constructed by W. C. Wiley, I. H. McLaren, and D. B. Harrington.
Gohlke, Roland S., McLafferty, Fred W.
openaire   +2 more sources

A Preliminary Study to Determine the Hydrogen and Oxygen Isotopic Compositions of Natural and Bottled Water using High Sensitivity Isotope Ratio Mass Spectrometry [PDF]

Geo Data, 2021
In this study, we introduce the stable isotopic results of water using a recently installed high sensitivity isotope ratio mass spectrometry (HS-IRMS) system at the Korea Institute of Geoscience and Mineral Resources (KIGAM).
Hyeongseok Song, Hui Je Jo, Dongwoo Yang
doaj   +1 more source

Development of an Accurate Mass Retention Time Database for Untargeted Metabolomic Analysis and Its Application to Plasma and Urine Pediatric Samples

Molecules, 2021
Liquid-chromatography coupled to high resolution mass spectrometry (LC-HRMS) is currently the method of choice for untargeted metabolomic analysis. The availability of established protocols to achieve a high confidence identification of metabolites is ...
Chiara Lavarello, Sebastiano Barco, Martina Bartolucci, Isabella Panfoli, Emanuele Magi, Gino Tripodi, Andrea Petretto, Giuliana Cangemi   +7 more
doaj   +1 more source

Bioanalytical LC-QTOF/MS Method for a N-phenylpiperazine Derivate (LQFM05): An Anxiolytic- and Antidepressant-like Prototype Drug Applied to Pharmacokinetic and Biodistribution Studies

Pharmaceuticals, 2023
The LQFM05 is a prototype drug designed for treatment of psychiatric disorders, such as schizophrenia, exhibiting anxiolytic- and antidepressant-like (12 or 24 µmol/kg) effects in classical behavioral tests.
Ana Cláudia M. Ramos, Kênnia R. Rezende, Carolina M. Teixeira, Aline R. Fernandes, Heloa Santos, Rúbia Darc Machado, Ricardo Menegatti, Boniek G. Vaz, Andréa R. Chaves   +8 more
doaj   +1 more source

UHPLC-MS/MS Analysis of Cannabidiol and Its Metabolites in Serum of Patients with Resistant Epilepsy Treated with CBD Formulations

Pharmaceuticals, 2021
Cannabidiol (CBD) is a promising therapeutic agent with analgesic, myorelaxant, and anti-epileptic actions. Recently, a purified form of CBD (Epidiolex®) has been approved by the European Medicines Agency (EMA) for the treatment of two highly-refractory ...
Sara Malaca, Massimo Gottardi, Federica Pigliasco, Sebastiano Barco, Alessia Cafaro, Elisabetta Amadori, Antonella Riva, Martina Marcenaro, Pasquale Striano, Giuliana Cangemi, Roberta Pacifici, Simona Pichini, Francesco Paolo Busardò   +12 more
doaj   +1 more source

Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics. [PDF]

, 2018
Novel metabolites distinct from canonical pathways can be identified through the integration of three cheminformatics tools: BinVestigate, which queries the BinBase gas chromatography-mass spectrometry (GC-MS) metabolome database to match unknowns with ...
A El-Tayeb, AD Hanson, AL Hartman, Atsushi Ogiwara, C Fattuoni, C Ruttkies, CL Linster, DY Lee, F Allen, Gert Wohlgemuth, GJ Patti, H Sperber, H Tsugawa, H Tsugawa, H Tsugawa, HD Flosadóttir, Hiroshi Tsugawa, I Yamamoto, J Budczies, JG Jeffryes, John Meissen, K Haug, Kohei Takeuchi, M Sud, Masanori Arita, Matthew Mueller, Megan Showalter, MP Styczynski, MR Showalter, O Fiehn, O Fiehn, O Fiehn, O Khersonsky, Oliver Fiehn, Peter Beal, RR da Silva, S Kim, S Kumari, Sajjan Mehta, SE Stein, SM Rappaport, T Kind, Tobias Kind, WR Wikoff, Yuxuan Zheng, Zijuan Lai   +45 more
core   +1 more source

A new finding in the old Knoevenagel condensation reaction

Results in Chemistry, 2022
Reaction of benzaldehyde (5a) with defined quantities of ethyl cyanoacetate (6) in presence of piperidine was studied. In a neat condition, hexasubstituted cyclohexeneamine (7a) with three ester substituents was formed along with ethyl acrylate (9a ...
Attimogee Shivamurthy Harisha, Kuppuswamy Nagarajan, S.Saravanan, Venkat Manohar, Sajesh P. Thomas, Tayur Narasingarow Guru Row   +5 more
doaj   +1 more source