Results 21 to 30 of about 3,985,069 (299)

UHPLC-MS/MS Analysis of Cannabidiol and Its Metabolites in Serum of Patients with Resistant Epilepsy Treated with CBD Formulations

Pharmaceuticals, 2021
Cannabidiol (CBD) is a promising therapeutic agent with analgesic, myorelaxant, and anti-epileptic actions. Recently, a purified form of CBD (Epidiolex®) has been approved by the European Medicines Agency (EMA) for the treatment of two highly-refractory ...
Sara Malaca, Massimo Gottardi, Federica Pigliasco, Sebastiano Barco, Alessia Cafaro, Elisabetta Amadori, Antonella Riva, Martina Marcenaro, Pasquale Striano, Giuliana Cangemi, Roberta Pacifici, Simona Pichini, Francesco Paolo Busardò   +12 more
doaj   +1 more source

Combining peak- and chromatogram-based retention time alignment algorithms for multiple chromatography-mass spectrometry datasets [PDF]

, 2012
Hoffmann N, Keck M, Neuweger H, et al. Combining peak- and chromatogram-based retention time alignment algorithms for multiple chromatography-mass spectrometry datasets. BMC Bioinformatics.
Keck, Matthias, Wilhelm, Mathias, Neuweger, Heiko, Stoye, Jens ; https://orcid.org/, Ching-Wei Wang, Hoffmann, Nils ; https://orcid.org/, Högy, Petra, Wang Ching-Wei, Niehaus, Karsten   +8 more
core   +1 more source

Quantification of voriconazole in plasma by liquid chromatography-tandem mass spectrometry [PDF]

, 2005
A convenient liquid chromatography-tandem mass spectrometry method for the quantification of the triazole antifungal agent voriconazole in plasma samples is described. Fenbuconazole is used as an internal standard.
Spöhrer, Ute, Schiel, Xaver, Vogeser, Michael   +2 more
core   +1 more source

A new finding in the old Knoevenagel condensation reaction

Results in Chemistry, 2022
Reaction of benzaldehyde (5a) with defined quantities of ethyl cyanoacetate (6) in presence of piperidine was studied. In a neat condition, hexasubstituted cyclohexeneamine (7a) with three ester substituents was formed along with ethyl acrylate (9a ...
Attimogee Shivamurthy Harisha, Kuppuswamy Nagarajan, S.Saravanan, Venkat Manohar, Sajesh P. Thomas, Tayur Narasingarow Guru Row   +5 more
doaj   +1 more source

Cannabidiol Determination on Peripheral Capillary Blood Using a Microsampling Method and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry with On-Line Sample Preparation

Molecules, 2020
The aim of this work is to evaluate volumetric absorptive microsampling (VAMS) from capillary blood as an alternative strategy for therapeutic drug monitoring (TDM) in patients treated with the newly available GW-purified form of cannabidiol (Epidiolex®).
Federica Pigliasco, Sebastiano Barco, Sara Dubois, Francesca Marchese, Pasquale Striano, Tommaso Lomonaco, Francesca Mattioli, Gino Tripodi, Giuliana Cangemi   +8 more
doaj   +1 more source

Untargeted LC-HRMS Based-Plasma Metabolomics Reveals 3-O-Methyldopa as a New Biomarker of Poor Prognosis in High-Risk Neuroblastoma

Frontiers in Oncology, 2022
Neuroblastoma (NB) is the most common extracranial malignant tumor in children. Although the survival rate of NB has improved over the years, the outcome of NB still remains poor for over 30% of cases.
Sebastiano Barco, Chiara Lavarello, Davide Cangelosi, Martina Morini, Alessandra Eva, Luca Oneto, Paolo Uva, Gino Tripodi, Alberto Garaventa, Massimo Conte, Andrea Petretto, Giuliana Cangemi   +11 more
doaj   +1 more source

A Volumetric Absorptive Microsampling Technique to Monitor Cannabidiol Levels in Epilepsy Patients

Frontiers in Pharmacology, 2020
Purpose: Interest in cannabis-based therapies has recently increased, due to the availability of cannabidiol (CBD) for the treatment of epilepsy without psychoactive effects.
Sara Dubois, Francesca Marchese, Federica Pigliasco, Sebastiano Barco, Gino Tripodi, Tommaso Lomonaco, Simona Lattanzi, Emilio Russo, Giuliana Cangemi, Pasquale Striano, Pasquale Striano   +10 more
doaj   +1 more source

Analysis of Cannabinoids Concentration in Cannabis Oil Galenic Preparations: Harmonization between Three Laboratories in Northern Italy

Pharmaceuticals, 2021
Medical cannabis is increasingly being used in the treatment and support of several diseases and syndromes. The quantitative determination of active ingredients (delta-9 tetrahydrocannabinol, THC, and cannabidiol, CBD) in galenic oily preparations is ...
Alice Palermiti, Alessia Cafaro, Sebastiano Barco, Paolo Bucchioni, Paolo Franceschini, Jessica Cusato, Amedeo De Nicolò, Alessandra Manca, Elisa Delia De Vivo, Eleonora Russo, Francesco Cecchi, Federica Pigliasco, Flavia Lillo, Gino Tripodi, Antonio D’Avolio, Giuliana Cangemi   +15 more
doaj   +1 more source

An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry [PDF]

, 2012
Background: Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin.
Rieger, Christina, Michael Vogeser, Ostermann, Helmut, Barbara Maier, Christina Rieger, Helmut Ostermann, Fabian Kirchhoff, Spoehrer, Ute, Vogeser, Michael, Ute Spöhrer, Maier, Barbara, Kirchhoff, Fabian   +11 more
core   +1 more source

Evaluation of Antioxidant and Cytotoxic Activity of Hydro-Ethanolic Extracts Obtained from Steiractinia aspera Cuatrec

Molecules, 2022
In this work, the antioxidant activity of the hydro-ethanolic extracts of the leaves, flowers, and aerial parts of Steiractinia aspera Cuatrec, both fresh and post-distillation, was evaluated by ABTS+·, FRAP, H2O2 and DPPH assays.
Laura Gamboa-Carvajal, Carlos Jara-Gutiérrez, Joan Villena, Lautaro Taborga, Jairo René Martínez, Luis Espinoza, Elena E. Stashenko   +6 more
doaj   +1 more source