Results 61 to 70 of about 959,191 (335)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Gender‐dependent association between exhaled nitric oxide and the CC16 38AA genotype in young school children

Immunity, Inflammation and Disease, 2020
Background Studies that investigated the association between the CC16 A38G polymorphism and the risk of asthma yielded conflicting results. The aim of this study among schoolchildren was to assess the relationships of CC16 A38G polymorphism with ...
Sarah J. D. Nauwelaerts, Nancy H. C. Roosens, Koen De Cremer, Alfred Bernard, Sigrid C. J. De Keersmaecker   +4 more
doaj   +1 more source

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. [PDF]

, 2009
We used on-line electron capture dissociation (ECD) for the large scale identification and localization of sites of phosphorylation. Each FT-ICR ECD event was paired with a linear ion trap collision-induced dissociation (CID) event, allowing a direct ...
Akbarzadeh, Bailey, Beausoleil, Blom, Chi, Christopher M. Bailey, Cooper, Cooper, Creese, Creese, Debbie L. Cunningham, Ding, Ficarro, Geer, Good, Helen J. Cooper, John K. Heath, Kelleher, Kjeldsen, Lind, Littlefield, Mirgorodskaya, Molina, Molina, Nielsen, Olsen, Palumbo, Perkins, Rush, Ruttenberg, Satake, Savitski, Savitski, Savitski, Shen, Steen, Stensballe, Steve. M.M Sweet, Sweet, Sweet, Sweet, Syka, Thingholm, Thingholm, Wan, Woodling, Zubarev, Zubarev   +47 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Research progress of HS-SPME-GC-MS in the detection of volatile substances in fruit products

Shipin yu jixie, 2023
From the perspective of the application of headspace solid-phase microextraction-mass spectrometry coupled with gas chromatography-mass spectrometry （HS-SPME-GC-MS） technology in the detection of volatile substances in fruit products, this paper ...
PANG Ji-wei, YIN Fei-long, LIU Yun-fen, QU De-zhi, LIANG Yuan-li, XIE Dong-di, LIAO Ling-yan, SHUAI Liang   +7 more
doaj   +1 more source

A Mammalian Mediator Subunit that Shares Properties with Saccharomyces cerevisiae Mediator Subunit Cse2 [PDF]

, 2004
The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. We previously identified and partially purified a mammalian Mediator complex from rat liver nuclei (Brower ...
Banks, Charles A. S., Brower, Christopher S., Conaway, Joan Weliky, Conaway, Ronald C., Florens, Laurence, Parmely, Tari J., Sato, Shigeo, Sorokina, Irina, Tomomori-Sato, Chieri, Washburn, Michael P., Zybailov, Boris   +10 more
core   +1 more source

Fatty acid profiles of milk from Holstein cows, Jersey cows, buffalos, yaks, humans, goats, camels, and donkeys based on gas chromatography–mass spectrometry [PDF]

, 2021
Fengen Wang, Meiqing Chen, Runbo Luo, Guoxin Huang, Xufang Wu, Nan Zheng, Yangdong Zhang, Jiaqi Wang   +7 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Peak Alignment of Gas Chromatography-Mass Spectrometry Data with Deep Learning

, 2019
We present ChromAlignNet, a deep learning model for alignment of peaks in Gas Chromatography-Mass Spectrometry (GC-MS) data. In GC-MS data, a compound's retention time (RT) may not stay fixed across multiple chromatograms. To use GC-MS data for biomarker
Li, Mike, Wang, X. Rosalind
core   +1 more source

Development and application of an UHPLC-MS/MS method for the simultaneous determination of 17 steroidal hormones in equine serum [PDF]

, 2017
A new, fast and simple analytical method that is able to identify and quantify simultaneously 17 steroid hormones and metabolites (Pregnenolone, 17-OH-Pregnenolone, Progesterone, 17-OH Progesterone, Androsterone, Androstenedione, DHEA, DHEAS ...
Allis, Bonfiglio, Büttler, Caron, Ceglarek, Goros, Guan, Huang, Kaabiaa, Kappas, Ke, Magnisali, Peitzsch, Ray, Schioler, Shao, Stanczyk, Taieb, Thomas, Wong, You   +20 more
core   +1 more source