Results 71 to 80 of about 3,985,069 (299)

The Analysis of Recreational Drugs in Biological Specimens Using Liquid Chromatography Mass Spectrometry [PDF]

, 2008
In the last few years, the prevalence of legal party pills in New Zealand has risen dramatically. These pills contain new piperazine designer drugs, two of the more common being 1-benzylpiperazine (BZP) and m-trifluoromethylphenylpiperazine (TFMPP). This
Lucas, Natasha
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Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

A Systematic Review of the Protective Actions of Cat’s Whiskers (Misai Kucing) on the Central Nervous System

Frontiers in Pharmacology, 2020
Orthosiphon stamineus (OS) or Orthosiphon aristatus var. aristatus (OAA) is commonly known as cat’s whiskers or “misai kucing”. It is an herbaceous shrub that is popular in many different traditional and complementary medicinal systems.
Yin-Sir Chung, Yin-Sir Chung, Brandon Kar Meng Choo, Pervaiz Khalid Ahmed, Pervaiz Khalid Ahmed, Iekhsan Othman, Iekhsan Othman, Mohd. Farooq Shaikh   +7 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A VAMS‐based LC–MS/MS method for precise cenobamate quantification in epilepsy (patients)

Epilepsia Open
Objective Cenobamate (CNB), a recently approved antiseizure medication by the European Medicines Agency (EMA), serves as an adjunctive therapy for focal‐onset seizures in adult patients unresponsive to at least two other treatments.
Federica Pigliasco, Alessia Cafaro, Sebastiano Barco, Margherita Biondi, Manuela Stella, Francesca Mattioli, Antonella Riva, Ugo deGrazia, Linda Molteni, Elisa Micalizzi, Flavio Villani, Pasquale Striano, Roberto Bandettini, Giuliana Cangemi   +13 more
doaj   +1 more source

Impact of Environmental Weathering on the Chemical Composition of Spilled Oils in a Real Case in Brazil

Coasts
Brazil suffered the largest oil spill disaster in its history, beginning on August 2019, affecting the Northeast coast. This study proposes a chemical investigation of oils from the 2019 spill in Brazil, which had naturally undergone different weathering
Ana Beatriz A. de M. Salata, Marília G. A. Pereira, Isabelle F. S. de Lima, Ignes Regina dos Santos, Danielle M. M. Franco, Boniek G. Vaz, Jandyson M. Santos   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Focal Point: Hyphenated Mass Spectrometry: A. Liquid Chromatography – Mass Spectrometry

CHIMIA, 2003
The identification of unknown compounds is essential in a wide variety of research areas and especially so in environmental analysis. Combining liquid chromatography with tandem mass spectrometry today allows the identification of substances ...
W. Giger
doaj   +1 more source

Probing the Composition, Assembly and Activity of Protein Molecular Machines using Native Mass Spectrometry [PDF]

, 2017
Native mass spectrometry and mass spectrometry in general, are powerful analytical tools for studying proteins and protein complexes. Native mass spectrometry may provide accurate mass measurements of large macromolecular assemblies enabling the ...
van de Waterbeemd, M.J., Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics   +2 more
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