Results 61 to 70 of about 10,732 (222)

Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) Complexes

open access: yesBioinorganic Chemistry and Applications, 2014
Ni(II) and Zn(II) complexes were synthesized from tridentate 3-formyl chromone Schiff bases such as 3-((2-hydroxyphenylimino)methyl)-4H-chromen-4-one (HL1), 2-((4-oxo-4H-chromen-3-yl)methylneamino)benzoic acid (HL2), 3-((3-hydroxypyridin-2-ylimino)methyl)
Palakuri Kavitha, K. Laxma Reddy
doaj   +1 more source

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

open access: yesChirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz   +1 more
wiley   +1 more source

Chemoenzymatic synthesis of both enantiomers of 3-hydroxy-2,3-dihydro-4H-chromen-4-one

open access: yes, 2003
4-Oxo-3,4-dihydro-2-chromen-3-yl acetate is synthesized using manganese(III)acetate starting from 2,3-dihydro-4H-chromen-4-one. K2CO3 mediated hydrolysis of 4-oxo-3,4-dihdro-2-chromen-3-yl acetate furnished 3-hydroxy-2,3-dihydro-4H-chromen-4-one in high ...
Sesenoglu, O   +4 more
core   +1 more source

Revised Structure by Computational Methods for a Coumarin Isolated from (Rutaceae)

open access: yesNatural Product Communications, 2008
On the basis of theoretical methods using DFT/B3LYP/6-31G * geometries and HF/6-311+G** GIAO NMR predictions, the 13 C NMR spectroscopic data of a coumarin from Zanthoxylum rhoifolium was reassigned.
Augusto Rivera, Jaime Rios-Motta
doaj   +1 more source

Tectorigenin monohydrate: an isoflavone from Belamcanda chinensis

open access: yesActa Crystallographica Section E, 2008
The title compound [systematic name: 5,7-dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one monohydrate], C16H12O6·H2O, is isolated from Belamcanda chinensis and is said to have antimicrobiotic and anti-inflammatory effects. The chromen-4-one
Benguo Liu   +3 more
doaj   +1 more source

Coumarins Disrupt Cell–Cell Communication and Virulence in Priority Pathogens: Targeting the PQS Signalling System in Pseudomonas aeruginosa

open access: yesMicrobial Biotechnology, Volume 19, Issue 7, July 2026.
The selective nature through which coumarin compounds produced by different species of plants target PQS signalling in Pseudomonas aeruginosa and select for distinct phenotypic responses in key pathogenic organisms adds to the growing evidence of their utility as natural virulence suppressors. ABSTRACT Cell‐to‐cell communication in microbial systems is
Dylan Boon   +8 more
wiley   +1 more source

Highly Active Cu14 Cluster Precisely Activates Autophagy Inhibitor to Amplify Cuproptosis Immunotherapy

open access: yesAdvanced Science, Volume 13, Issue 33, 15 June 2026.
An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang   +8 more
wiley   +1 more source

Unprecedented formation of 3-(tetrahydrofuran-2-yl)-4H-chromen-4-one in a reaction between 3,3a-dihydro-9H-furo[3,4-b]chromen-9-one and malononitrile

open access: yes, 2017
A solvent-controlled reaction of 3,3a-dihydro-9H-furo[3,4-b]chromen-9-one with malononitrile to access 3-(tetrahydrofuran-2-yl)-4H-chromen-4-one is described.
Hong-Yan Huang   +5 more
core   +1 more source

Synthesis and Characterization of New Thiazolidinones Containing Coumarin Moieties and Their Antibacterial and Antioxidant Activities

open access: yesMolecules, 2012
New coumarin derivatives, namely (2-(4-methyl-2-oxo-<em>2H</em>-chromen-7-yloxy)-<em>N</em>-(4-oxo-2-phenylthiazolidin-3-yl)acetamide, <em>N</em>-(2-(3-methoxyphenyl)-4-oxothiazolidin-3-yl)-2-(4-methyl-2-oxo-<em> ...
Alary Fabienne   +3 more
doaj   +1 more source

Uroporphyrinogen decarboxylase as a potential target for specific components of traditional Chinese medicine: a virtual screening and molecular dynamics study. [PDF]

open access: yesPLoS ONE, 2012
Uroporphyrinogen decarboxylase (UROD) has been suggested as a protectant against radiation for head and neck cancer (HNC). In this study, we employed traditional Chinese medicine (TCM) compounds from TCM Database@Taiwan (http://tcm.cmu.edu.tw/) to screen
Yung-An Tsou   +4 more
doaj   +1 more source

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