Results 71 to 80 of about 10,732 (222)

Synthesis of Chromen-2-one, Pyrano[3,4-c]chromene and Pyridino[3,4-c]chromene Derivatives as Potent Antimicrobial Agents

Croatica Chemica Acta, 2018
In an attempt for development of new antimicrobial agents; new series of chromen-2-one, pyrano [3,4-c]chromene and pyridino [3,4c]chromene derivatives bearing a diazo moiety were synthesized.Chromen-2-one derivatives were synthesized via treatment of 5-(aryldiazo) salicylaldehyde with different type of active methylene derivatives.Pyrano[3,4-c]chromene
Sawsan A. Fouad, Sadia A. Hessein, Samir Y. Abbas, Ayman A. Farrag, Yousry A. Ammar   +4 more
openaire   +1 more source

Green Biosynthesis of Bioactive Streptomyces Metabolites Using Edible Mushrooms: Implications for Glycemic Control and Hepatic Protection in Diabetic Rats

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Mushroom‐mediated Streptomyces metabolites improved fasting blood glucose, reduced hepatic injury markers, restored antioxidant defenses, and showed supportive molecular docking interactions, indicating potential as a functional food or nutraceutical for diabetes‐associated metabolic and liver protection.
Yahye Ahmed Nageye, Abdirasak Sharif Ali, Kizito Eneye Bello   +2 more
wiley   +1 more source

Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2H-chromen-2-one Derivatives and Their Biological Evaluation

Journal of Chemistry, 2020
A series of (E)-3-(2-((5-(benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) acetyl)-2H-chromen-2-one and its derivatives (4a-h) have been obtained using a one-pot multicomponent reaction with good yields.
Shivanand Merugu, Vijaya Kumar Ponnamaneni, Ravi Varala, Syed Farooq Adil, Mujeeb Khan, Mohammed Rafiq H. Siddiqui, Ravikumar Vemula   +6 more
doaj   +1 more source

Synthesized flavone attenuates diabetes‐induced neurodegeneration through regulation of oxidative stress and metabolic‐neurodegenerative molecular pathways

Ibrain, Volume 12, Issue 2, Page 259-272, Summer 2026.
Neuroprotective efficacy of flavone (2‐phenyl‐4H‐chromen‐4‐one). The study aimed to explore the potential of a synthetic derivative (flavone) of a phytocompound, which is involved in neuroprotection activities. Experimental strategies included the characteristics of compound, in‐silico analysis, and in vivo assessments.
Karishma Sen, Anita Sakarwal, Heera Ram, Suman K. Saha, Nirmal K. Rana, Dharmveer Yadav, Sunil Dutt Shukla, Mukesh Kumar Yadav, Balachandar Vellingiri, Vikas Kumar   +9 more
wiley   +1 more source

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?

Phytotherapy Research, Volume 40, Issue 6, Page 3354-3368, June 2026.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo, Cristiana Lucia Rita Lipari, Aurora Patti, Maria Angela Sortino   +3 more
wiley   +1 more source

Utility of 3-Acetyl-6-bromo-2H-chromen-2-one for the Synthesis of New Heterocycles as Potential Antiproliferative Agents

Molecules, 2015
Coumarin derivatives containing pyrazolo[1,5-a]pyrimidine, tetrazolo[1,5-a]pyrimidine, imidazo[1,2-a]pyrimidine, pyrazolo[3,4-d]pyrimidine, 1,3,4-thiadiazoles and thiazoles were synthesized from 6-bromo-3-(3-(dimethylamino)acryloyl)-2H-chromen-2-one ...
Sobhi M. Gomha, Yasser H. Zaki, Abdou O. Abdelhamid   +2 more
doaj   +1 more source

Synthesis, Cytotoxicity, and ADME Studies of New Compounds Containing Coumarin–Indazole–Triazole Nucleus

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
In this work, the preparation of new coumarin–indazole–triazole–sulfonamide hybrids via a multistep route has been fine‐tuned. The synthesis involves nitration, reduction, formation of a sulfonamide, alkylation, and CuAAC coupling. The synthesized compounds were screened for antiproliferative activity against MDA‐MB‐231 triple‐negative breast cancer ...
Achraf Hibot, Mümin Alper Erdoğan, Abderrafia Hafid, Mostafa Khouili, Güliz Armagan, Maria Dolors Pujol   +5 more
wiley   +1 more source

Synthesis of 3-Tetrazolylmethyl-4H-Chromen-4-Ones Via Ugi-Azide Reaction Catalyzed by ZnO Nanoparticles

, 2019
A serie of novel 3-tetrazolylmethyl-4H-chromen-4-ones were synthesized via Ugi-azide reaction under mild ultrasound-assisted conditions (room temperature, EtOH, 10% mol ZnO nanoparticles). The products containing two privileged heterocyclic frameworks: 1,
Rocío Gámez-Montaño, Manuel A. Rentería-Gómez   +1 more
core   +1 more source

Comprehensive Evaluation of Fructus Tsaoko, Seeds of Tsaoko Fructus and Ginger Made Seeds of Tsaoko Fructus Based on Drug‐Like Compounds and Aroma Analysis

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
This study mainly consists of two parts. First, after screening for drug‐like metabolites via LC–MS and GC–MS, a comprehensive evaluation model was established using a principal component analysis‐based weighted scoring method, by which the drug‐likeness ranking of three samples was determined.
Han Chen, Meiquan Yang, Weize Yang, Mingju Qi, Zongliang Xu, Tianmei Yang, Jinyu Zhang   +6 more
wiley   +1 more source

3-(bromomethyl)chromen-2-one

, 2019
This dataset contains experimental data from a sample (3-(bromomethyl)chromen-2-one, InChI=1S/C10H7BrO2/c11-6-8-5-7-3-1-2-4-9(7)13-10(8)12/h1-5H,6H2).
Bräse, Stefan, Mohr, Florian
core   +1 more source