Results 1 to 10 of about 30,456 (242)

The mechanisms of chromogranin B-regulated Cl- homeostasis. [PDF]

Biochem Soc Trans, 2022
Chloride is the most abundant inorganic anions in almost all cells and in human circulation systems. Its homeostasis is therefore important for systems physiology and normal cellular activities. This topic has been extensively studied with chloride loaders and extruders expressed in both cell surfaces and intracellular membranes.
Jiang QX, Yadav G.
europepmc   +3 more sources

Circulating Chromogranin B Is Associated With Left Ventricular Functional Recovery After Successful Recanalization of Chronic Total Occlusion [PDF]

Frontiers in Cardiovascular Medicine, 2021
Background: Chromogranin B (CgB) is increased in heart failure and proportionate to disease severity. We investigated whether circulating CgB level is associated with left ventricular (LV) functional recovery potential after successful recanalization of ...
Ying Shen, Muladili Aihemaiti, Xin Yi Shu, Chen Die Yang, Jia Wei Chen, Yang Dai, Feng Hua Ding, Zhen Kun Yang, Jian Hu, Rui Yan Zhang, Lin Lu, Lin Lu, Xiao Qun Wang, Xiao Qun Wang, Wei Feng Shen, Wei Feng Shen   +15 more
doaj   +2 more sources

Chromogranin B (CHGB) is dimorphic and responsible for dominant anion channels delivered to cell surface via regulated secretion [PDF]

Frontiers in Molecular Neuroscience, 2023
Regulated secretion is conserved in all eukaryotes. In vertebrates granin family proteins function in all key steps of regulated secretion. Phase separation and amyloid-based storage of proteins and small molecules in secretory granules require ion ...
Gaya P. Yadav, Gaya P. Yadav, Gaya P. Yadav, Haiyuan Wang, Joke Ouwendijk, Stephen Cross, Qiaochu Wang, Feng Qin, Paul Verkade, Michael X. Zhu, Qiu-Xing Jiang, Qiu-Xing Jiang, Qiu-Xing Jiang, Qiu-Xing Jiang   +13 more
doaj   +2 more sources

Lower serum chromogranin B level is associated with type 1 diabetes and with type 2 diabetes patients with intensive conservative insulin treatment [PDF]

Diabetology & Metabolic Syndrome, 2020
Background Chromogranin B (CgB) plays an important role in the physiological insulin secretion of pancreatic beta cells. Serum CgB levels were investigated in type 1 and type 2 diabetes patients in a cross-sectional study.
Zoltan Herold, Magdolna Herold, Klara Rosta, Marton Doleschall, Aniko Somogyi   +4 more
doaj   +2 more sources

Chromogranin B Purification for Condensate Formation and Client Partitioning Assays In Vitro [PDF]

Bio-Protocol
Chromogranin B and other members of the granin protein family form condensates that recruit clients like proinsulin. The condensation in the lumen of trans-Golgi network (TGN) is critical for the biogenesis of secretory granules.
Anup Parchure, Julia von Blume
doaj   +2 more sources

Value of Immunohistochemical Expression of Apelin, Succinate Dehydrogenase B, Chromogranin B, Human Epidermal Growth Factor Receptor-2, Contactin 4, and Succinyl-CoA Synthetase Subunit Beta in Differentiating Metastatic From Non-Metastatic Pheochromocytoma and Paraganglioma [PDF]

Frontiers in Endocrinology, 2022
ObjectiveWe aimed to retrospectively collect pathologically identified pheochromocytoma and paraganglioma (PPGL) tumor tissues from our center and investigate the expression of apelin and succinyl-CoA synthetase subunit beta (SUCLG2), human epidermal ...
Yong Wang, Yong Wang, Danlei Chen, Yingxian Pang, Xiaowen Xu, Xiao Guan, Xiao Guan, Longfei Liu, Longfei Liu   +8 more
doaj   +2 more sources

Chromogranin B Protects Human Umbilical Endothelial Cells against Oxidative Stress. [PDF]

Int J Mol Sci
Chromogranin B (CgB) is involved in the control of the cardiovascular system through the regulation of catecholamine release. Whether CgB can exert direct actions on the endothelium has not yet been clarified. Here, we aimed to investigate the effects of CgB on cell viability, mitochondrial membrane potential, reactive oxygen species (ROS), glutathione
Grossini E, Venkatesan S, Ola Pour MM, Ferrante D, Surico D, Vaschetto R, Cantaluppi V, Pirisi M.   +7 more
europepmc   +4 more sources

Utility of chromogranin B compared with chromogranin A as a biomarker in Japanese patients with pancreatic neuroendocrine tumors. [PDF]

Jpn J Clin Oncol, 2017
Currently, serum chromogranin A is a well-established biomarker for pancreatic neuroendocrine tumors; however, other pancreatic diseases, oral use of a proton pump inhibitor and renal impairment can affect chromogranin A. Meanwhile, chromogranin B, belonging to the same granin family as chromogranin A, is not fully examined in these conditions.
Miki M, Ito T, Hijioka M, Lee L, Yasunaga K, Ueda K, Fujiyama T, Tachibana Y, Kawabe K, Jensen RT, Ogawa Y.   +10 more
europepmc   +4 more sources

Salivary Stress Biomarkers (Chromogranin A and Secretory IgA): Associations with Anxiety and Depressive Symptoms in Healthcare Professionals [PDF]

Nursing Reports
Background/Objectives: Shift-working healthcare professionals are exposed to high psychophysiological demands associated with occupational stress, anxiety, and depressive symptoms.
Tanya Deneva, Youri Ianakiev, Snezhana Stoencheva   +2 more
doaj   +2 more sources

Defective secretion of islet hormones in chromogranin-B deficient mice. [PDF]

PLoS ONE, 2010
Granins are major constituents of dense-core secretory granules in neuroendocrine cells, but their function is still a matter of debate. Work in cell lines has suggested that the most abundant and ubiquitously expressed granins, chromogranin A and B (CgA
Stefanie Obermüller, Federico Calegari, Angus King, Anders Lindqvist, Ingmar Lundquist, Albert Salehi, Maura Francolini, Patrizia Rosa, Patrik Rorsman, Wieland B Huttner, Sebastian Barg   +10 more
doaj   +1 more source