Results 91 to 100 of about 35,640 (295)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Fluorescence in situ hybridisation for interphase chromosomal aberration-based biological dosimetry. [PDF]

Radiat Prot Dosimetry, 2023
Meher PK, Lundholm L, Wojcik A.
europepmc   +1 more source

Chromosomal integrity after UV irradiation requires FANCD2-mediated repair of double strand breaks [PDF]

, 2016
Fanconi Anemia (FA) is a rare autosomal recessive disorder characterized by hypersensitivity to inter-strand crosslinks (ICLs). FANCD2, a central factor of the FA pathway, is essential for the repair of double strand breaks (DSBs) generated during fork ...
Bocco, Jose Luis, Di Giorgio, Marina, Federico, Maria Belén, Gottifredi, Vanesa, Paviolo, Natalia Soledad, Radl, Daniela Betiana, Soria, Gastón, Vallerga, María   +7 more
core   +3 more sources

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Cytogenetic Effects Of Tacrolimus After Chronic Oral Administration In Male Albino Rats

Kufa Journal for Veterinary Medical Sciences, 2015
This study was carried out to investigate cytogenetic effects of chronic exposure of an immunosuppressant Tacrolimus in male albino rats. Thirty albino male rats were divided into 3 equal groups, the first one (T1) administrated orally therapeutic dose ...
Ali Ibrahim Mohammed AL-Ameedi, Falah Muosa Kadhim AL-Rekabi, Zahraa Mohammed Ayad   +2 more
doaj   +1 more source

Chromosomal Aberration t(14;17)(q32;q21) Simultaneously Activates HOXB5 and miR10a in Triple-Hit B-Cell Lymphoma. [PDF]

Biomedicines, 2023
Nagel S, Pommerenke C, Meyer C, Kaufmann M, MacLeod RAF.   +4 more
europepmc   +1 more source

Assessment of Molecular Cytogenetic Methods for the Detection of Chromosomal Abnormalities [PDF]

, 2006
Some marker chromosomes and chromosome rearrangements are difficult to identify using G-bands by Giemsa staining after trypsin treatment (G-banding) alone.
Maruyama, Hidehiko, Morishima, Tsuneo, Ninomiya, Shinsuke, Shinozuka, Masako, Une, Tomoka, Yokoyama, Yuji   +5 more
core   +1 more source

Thermo‐Fluorescent Bactericidal Quantum Dots Based Smart Multifunctional Textiles via Molecular Surface Engineering and 3D‐Printed Interlocked Architectures

Advanced Healthcare Materials, EarlyView.
A versatile approach is presented for fabricating smart multifunctional textiles by integrating thermo‐fluorescent carbon dot/polymer nanocomposite coatings with 3D‐printed interlocked architectures. The fabrics exhibit temperature‐responsive fluorescence, durable hydrophobicity, strong antibacterial and antioxidant activity, and enhanced UV protection.
Poushali Das, Sayan Ganguly, Parham Khoshbakht Marvi, Misha Muthalali, Fatemeh Parniani, Shiza Hassan, Xiaowu (Shirley) Tang, Seshasai Srinivasan, Amin Reza Rajabzadeh   +8 more
wiley   +1 more source

Measuring cancer driving force of chromosomal aberrations through multi-layer Boolean implication networks.

PLoS ONE
Multi-layer Complex networks are commonly used for modeling and analysing biological entities. This paper presents the advantage of using COMBO (Combining Multi Bio Omics) to suggest a new role of the chromosomal aberration as a cancer driver factor ...
Ilaria Cosentini, Daniele Filippo Condorelli, Giorgio Locicero, Alfredo Ferro, Alfredo Pulvirenti, Vincenza Barresi, Salvatore Alaimo   +6 more
doaj   +1 more source

Incidental Detection of a Chromosomal Aberration by Array-CGH in an Early Prenatal Diagnosis for Monogenic Disease on Coelomic Fluid. [PDF]

Life (Basel), 2022
Vinciguerra M, Leto F, Cassarà F, Tartaglia V, Malacarne M, Coviello D, Cigna V, Orlandi E, Picciotto F, Cucinella G, Salzano E, Piccione M, Maggio A, Giambona A.   +13 more
europepmc   +1 more source