Results 81 to 90 of about 859,918 (327)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Outcomes associated with fetal nuchal translucency between 3.0 and 3.4 mm in the first trimester

Acta Obstetricia et Gynecologica Scandinavica
Introduction Decisions concerning nuchal translucency (NT) between 3.0 and 3.4 mm remain controversial, particularly regarding whether to first calculate the combined first trimester screening test or to proceed directly with invasive testing.
Manon D. E. Vriendt, Caroline Rooryck, Hugo Madar, Frédéric Coatleven, Marie Vincienne, Perrine Prier, Sophie Naudion, Loïc Sentilhes, Hanane Bouchghoul   +8 more
doaj   +1 more source

The Exposure Effect of Water Pipe Smoke (WPS) on the Total Count leukocyte, Mitotic Index, Micronucleus Formation and Chromosome Aberration in Albino Male Mice

مجلة مركز بحوث التقنيات الاحيائية, 2015
The present study was carried out to evaluate the hematological and cytogenetic effects of water pipe smoke (WPS) in albino male mice. The investigated parameters were total count of leukocytes (TCL), mitotic index (MI), micronucleus (MN) formation and ...
Mohammad M. F. Al-Halbosiy, Rakad M. Kh. Al-Jumaily, Fadhel M. Lafta   +2 more
doaj   +1 more source

Development of a Biological Dosimeter for Translocation Scoring Based on Two-Color Fluorescence in Situ Hybridization of Chromosome Subsets [PDF]

, 1992
Recently fluorescence in situ hybridization protocols have been developed which allow the paining of individual chromosomes using DNA-libraries from sorted human chromosomes.
Cremer, Thomas, Popp, Susanne
core  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The Genetic Of Mental Retardation [PDF]

, 2005
Mental retardation is a common problem with major implications for a nation’s health, education and community services. The causes of mental retardation have been found to have a definite etiological basis, which may be biochemical, chromosomal ...
Faradz, Sultana M.H.
core  

Prenatal diagnosis of ring chromosome 13: a rare chromosomal aberration

, 2018
We report the case of a 24-year-old Japanese woman, gravida 2, para 1, who became pregnant spontaneously. At 24 weeks of gestation, her fetus was found to have various abnormalities, including holoprosencephaly, congenital heart disease and severe fetal ...
Masanobu Ogawa, Yuka Sato, Kiyoko Kato, Saki Kido, Yasuyuki Fujita, Haruka Goto   +5 more
core   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Genotoxicity evaluation of So-ochim-tang-gamibang (SOCG), a herbal medicine

BMC Complementary and Alternative Medicine, 2018
Background So-ochim-tang-gamibang (SOCG) is a traditional Korean medicine frequently used for depression in the clinical field. In this study, we evaluated the potential genotoxicity of SOCG using three standard batteries of tests as part of a safety ...
Mi Young Lee, Yang-Chun Park, Mirim Jin, Eunseok Kim, Jeong June Choi, In Chul Jung   +5 more
doaj   +1 more source

Chromosomal aberrations in cerebral visual impairment

, 2014
Item does not contain fulltextBACKGROUND: Cerebral visual impairment (CVI) is a disorder in projection and/or interpretation of the visual input in the brain and accounts for 27% of the visually impaired children. AIM: A large cohort of patients with CVI
Vries, L.B.A. de, Cremers, F.P.M., Reijnders, M.R., Boonstra, F.N., Pfundt, R.P., Bosch, D.G.M.   +5 more
core   +1 more source