Results 71 to 80 of about 859,918 (327)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Threshold of Nuchal Translucency for the Detection of Chromosomal Aberration: Comparison of Different Cut-offs

Journal of Korean medical science, 2006
This study evaluated the sensitivities and false positive rates of the screening test using ultrasonographic measurement of thickness of nuchal translucency (NT) with different cut-offs for chromosomal aberration in a Korean population. We included 2,570
Min‐Hyoung Kim, Su-Hyun Park, H. Cho, J. Choi, Joo-Oh Kim, H. Ahn, J. Shin, J. Han, Moon-Young Kim, J. Yang   +9 more
semanticscholar   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Acute Oral Toxicity and Genotoxicity of Polysaccharide Fraction from Young Barley Leaves (Hordeum vulgare L.)

Foods, 2020
Polysaccharides isolated from various plants are considered precious bioactive materials owing to their potent biological activities. Previously, we prepared a polysaccharide fraction (BLE0) isolated from young barley leaves (Hordeum vulgare L ...
Chang-Won Cho, Young-Ran Song, Won-Chul Lim, Youn-Hwan Hwang, Young Kyoung Rhee, Jae Woong Choi, Kyung-Tae Lee, Hee-Do Hong   +7 more
doaj   +1 more source

The effect of reduced mitochondria activity upon on embryo developments and chromosomal aberration in bovine embryos after ICSI (n = 11).

, 2015
n = number of replicated experiments.Letters within vertical columns indicate significant differences in chromosomal integrity (a-b: Chi square test ...
Yoku Kato (753019), Yoshikazu Nagao (753020)   +1 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Cytogenetic analysis of 3387 umbilical cord blood in pregnant women at high risk for chromosomal abnormalities

Molecular Cytogenetics, 2020
Background Cordocentesis in our practice is most commonly indicated for rapid karyotyping in the second or third trimester and is regarded as the gold standard for foetal chromosomal aberration diagnosis in pregnancies at high risk for chromosomal ...
Yanmei Sun, Pingping Zhang, Ning Zhang, Limin Rong, Xiaoping Yu, Xianghua Huang, Yali Li   +6 more
doaj   +1 more source

Placental mosaicism in the era of chromosomal microarrays

, 2020
Objective: Placental mosaicism for a subset of a chromosome, a structural chromosomal aberration, is thought to be a very rare finding in chorionic villus samples.
Vogel, Ida, Christensen, Rikke, Bogaard, Pauline, Vestergaard, Else Marie, Petersen, Astrid Christine, Lildballe, Dorte Launtoft, Sørensen, Anne Nødgaard; id_orcid, Sørensen, Anne Nødgaard Weidemann, Hoseth, Gerd-Eva   +8 more
core   +1 more source

Progenetix.net: an online repository for molecular cytogenetic aberration data [PDF]

, 2001
Through sequencing projects and, more recently, array-based expression analysis experiments, a wealth of genetic data has become accessible via online resources.
Baudis, Michael; https://orcid.org/, Cleary, Michael L   +1 more
core   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source