Results 61 to 70 of about 859,918 (327)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Toxicity Assessment of a No-Pain Pharmacopuncture Extract Using a Standard Battery of In Vitro Chromosome Aberration Tests

Journal of Pharmacopuncture
Objectives: Genotoxicity is evaluated through a chromosomal aberration test using cultured mammalian cells to determine the toxicity of no-pain pharmacopuncture (NPP), which has recently been used to treat musculoskeletal pain disorders in Korean medical
Ji Hye Hwang
doaj   +1 more source

Cytogenetic peculiarities of peripheral blood lymphocytes at cerebral glial tumor of different malignancy

Ukrainian Neurosurgical Journal, 2006
The statistically significant increase of chromosomal aberration frequency, aneuploidy and multiaberrant cells in nonmalignant somatic cells (peripheral blood lymphocytes) of patients with a glial tumor dependent on its malignancy was ...
I. V. Boltina, N. Ya. Gridina
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Radon concentration and related employees’ chromosome aberration and micronuclei in subways in a city of Zhejiang Province

环境与职业医学
BackgroundExcessive radon exposure is considered the second risk factor for lung cancer. Since the opening of the subway in a city of Zhejiang Province, the exposure level of radioactive gas radon in subway stations and its impact on occupational health ...
Zhiqiang XUAN, Xinyu HUANG, Zhongjun LAI, Jiadi GUO, Xiaoji HAO, Shunfei YU, Yiyao CAO, Donghang WANG, Duo ZHANG, Jihua NIE   +9 more
doaj   +1 more source

Combining Chromosomal Arm Status and Significantly Aberrant Genomic Locations Reveals New Cancer Subtypes

, 2009
Many types of tumors exhibit characteristic chromosomal losses or gains, as well as local amplifications and deletions. Within any given tumor type, sample specific amplifications and deletions are also observed.
Monika E. Hegi, Tal Shay, Monika E. Heg, Eytan Domany, Wanyu L. Lambiv, Anat Reiner-Benaim   +5 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Evaluation of cytotoxicity and genotoxicity of the upstream Citarum River using Allium cepa assay [PDF]

E3S Web of Conferences
Citarum River is the longest and largest river in West Java, and its existence greatly influences the lives of surrounding communities. Many industries are built around the area.
Annisa, Mulyawan Hafidh, Sunardi
doaj   +1 more source

Explainable Artificial Intelligence Approach Using Low-Dimensional Visualization and Ensembling Uncertainty Quantification for Rare Chromosomal Aberration Detection in Cytogenetic Imaging

International audienceMotivation: In biological dosimetry a radiation dose is estimated using the average number of chromosomal aberrations per peripheral blood lymphocytes. This analysis is manually performed and better automating chromosomal aberration
Gruel, Gaëtan, Benadjaoud, Mohamed‐amine, Martinez, Juan, Dugue, Delphine, Kervrann, Charles, Fernandez, Pascale, Moebel, Emmanuel, Deschemps, Antonin, Grégoire, Eric, Vaurijoux, Aurelie   +9 more
core   +1 more source