Results 91 to 100 of about 66,699 (303)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Microscopic Detection of Chromosomal Aberrations [PDF]
, 2009 Předkládaná bakalářská práce se věnuje oblasti cytogenetiky, zejména chromozomálním aberacím, které se vyskytujíu člověka. Teoretická část práce popisuje základní charakteristiku chromozómů a obsahuje souhrnný přehled mutagenních faktorů, které způsobují
Zajíčková Lenka
core
Translocation (8;21) in acute nonlymphocytic leukemia delineated by chromosomal in situ suppression hybridization [PDF]
, 1991 In situ suppression hybridization with recombinant bacteriophage DNA libraries for chromosomes 8 and 21 was performed in two cases of acute nonlymphocytic leukemia, type FAB M2.
Cremer, Thomas +5 more
core +1 more source
Genetic damages in radiation workers of radiology centers in Bushehr port
Iranian South Medical Journal, 2004 Unstable genetic aberrations might provide a good marker for assessing genetic damage in populations exposed to low levels of ionizing radiation.The frequency of these aberrations was estimated in peripheral lymphocytes from hospital workers in Bushehr ...
Gholamreza Khamisipour +3 more
doaj
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Overview of detected chromosomal aberrations by cCGH and aCGH [PDF]
, 2013 Overview of detected chromosomal aberrations by cCGH and ...
Kerstin Wahrheit (78022) +10 more
core +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Deletions identified at the breakpoints of the complex chromosomal aberrations. [PDF]
, 2019 Deletions identified at the breakpoints of the complex chromosomal aberrations.
Jesper Eisfeldt (5007209) +9 more
core +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Micronuclei versus Chromosomal Aberrations Induced by X-Ray in Radiosensitive Mammalian Cells
Iranian Journal of Public Health, 2015 Background: An experimental study was accomplished to compare estimation methods of ionizing radiations genotoxicity in mammalian cell cultures by means of two cytogenetic parameters with focus on aberrant cells characterized by multiple chromosomal ...
Cristina Plamadeala +2 more
doaj