Results 121 to 130 of about 246,792 (294)

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Study of chromosomal abnormalities in the somatic cells of patients with thyroid cancer who suffered from the Chernobyl accident

Фактори експериментальної еволюції організмів, 2013
Aims. Research level and spectrum of chromosomal aberrations in peripheral blood lymphocytes of patients with thyroid cancer, which were last ionizing radiation due to the Chernobyl accident. Methods. Сytogenetic analysis of human lymphocytes.
L. V. Neumerzitskaya, S. W. Klimenko, G. M. Koval, R. M. Werbilenko, V. N. Shkarupa   +4 more
doaj  

Frequency of spermatogonial chromosomal aberrations induced by indicated doses of dexrazoxane (Dex), epirubicin (Epi), or both.

, 2016
Spermatogonial chromosomal aberration was expressed as mean ± standard deviation (SD) of total aberrations/100 spermatogonial metaphases. *P P aP bP U-test).
Sheikh F. Ahmad (1474837), Mushtaq A. Ansaria (3186708), Othman A. Al-Shabanah (3186702), Sabry M. Attia (1474825), Saleh A. Bakheet (1474822), Mohammed M. Al-Harbi (3186705), Ahmed Nadeem (1474843)   +6 more
core   +1 more source

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

Advanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang, Gwanho Sung, Sujin Jo, Yeonhu Lee, Ho‐Chul Kang, Jae‐Ho Lee, Yong Won Choi, Hyeseong Cho, Sunwoo Min   +10 more
wiley   +1 more source

REALIZATION OF THE PHENOTYPIC EFFECT OF CHROMOSOMAL ABERRATIONS IN HUMANS

Вавиловский журнал генетики и селекции, 2014
Factors determining the phenotype formation in patients with abnormal karyotype (including those with Down’s syndrome) have been discussed for several decades.
K. N. Grinberg, V. I. Kukharenko
doaj  

Occurrence of chromosomal aberrations in blood lymphocyte metaphases of heterozygous MCPH1 c.904_916del mutation carriers and healthy controls.

, 2016
Occurrence of chromosomal aberrations in blood lymphocyte metaphases of heterozygous MCPH1 c.904_916del mutation carriers and healthy controls.
Robert Winqvist (146640), Katri Pylkäs (146646), Katrin Rapakko (2180022), Anna Tervasmäki (2180026), Tuomo Mantere (2180024), Saila Kauppila (553713), Arja Jukkola-Vuorinen (146651), Mervi Grip (146656)   +7 more
core   +1 more source

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

Chromosomal aberrations and cancer risk: Results of a cohort study from Central Europe

, 2007
A high level of chromosomal aberrations in peripheral blood lymphocytes may be an early marker of cancer risk, but data on risk of specific cancers and types of chromosomal aberrations (chromosome type and chromatid type) are limited.
Lazutka, Juozas, Kelecsenyi, Zsolt, Norppa, Hannu, Vermeulen, Roel, Cebulska-Wasilewska, Antonina, Fucic, Aleksandra, Gundy, Sarolta, Forni, Alessandra, Bonassi, Stefano, Rachtan, Jadwiga, Kurtinaitis, Juozas, Fabianova, Eleonora, Boffetta, Paolo, Puskailerova, Daniela, Znaor, Ariana, van der Hel, Olga, Rachtan, J., Lazutka, J., Forni, A., Bonassi, S., Vermeulen, R., Gundy, S., Boffetta, P., Cebulska-Wasilewska, A., Puskailerova, D., Znaor, A., Van Der Hel, O., Fabianova, E., Fucic, A., Kelecsenyi, Z., Kurtinaitis, J., Norppa, H.   +31 more
core   +1 more source

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Advanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou, Shu Ding, Zhenyi Zhang, Qiaoling Shangguan, Jie Qiao, Peijie Zhou, Yidong Chen   +6 more
wiley   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source