Results 91 to 100 of about 68,433 (279)

Cytogenetic Investigation in Couples with Recurrent Abortion and Poor Obstetric History

Gynecology Obstetrics & Reproductive Medicine, 2010
OBJECTIVES: The cause of recurrent early pregnancy wastage is often unknown. Cytogenetic studies have an important role in the evaluation of couples with repeated miscarriages and poor obstetric history.
Ebru Önalan Etem, Hüseyin Yüce, Deniz Erol, Şükriye Derya Deveci, Hüsnü Çelik, Halit Elyas   +5 more
doaj  

The Lived Experience of Klinefelter Syndrome: A Narrative Review of the Literature [PDF]

, 2019
open access ...
Cheetham, Tim, Fearon, Kristine, Hanna, Esmee, Herbrand, Cathy, Hudson, Nicky, McEleny, Kevin, Quinton, Richard, Stevenson, Eleanor, Wilkes, Scott   +8 more
core   +2 more sources

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

Chromosome microarray analysis as first-line test in pregnancies with a priori low risk for detection of submicroscopic chromosomal abnormalities [PDF]

, 2012
n this study, we aimed to explore the utility of chromosomal microarray analysis (CMA) in groups of pregnancies with a priori low risk for detection of submicroscopic chromosome abnormalities, usually not considered an indication for testing, in order to
A Breman, A Duncan, A Rauch, A Vetro, ACOG committee, Andrea Nuccitelli, Anthony Gordon, BA Bejjani, BB de Vries, BB Roa, BS Emanuel, C Le Caignec, CM Ogilvie, CN Lee, DT Miller, E Pergament, E Shuster, F Fiorentino, F Vialard, Fiorina Caiazzo, Francesco Fiorentino, G McGillivray, Giuseppe Rizzo, I Maya, IB Van den Veyver, J Coppinger, JM Friedman, K Metcalfe, L Armengol, L Kleeman, L Rickman, LE Vissers, Letizia Spizzichino, LG Shaffer, LG Shaffer, LG Shaffer, LG Shaffer, M Srebniak, M Strassberg, MA Crackower, Mariateresa Sessa, Marina Baldi, P Stankiewicz, R Hochstenbach, RJ Wapner, S Darilek, Sara Bono, SC Hillman, SJ Park, Stefania Napoletano, SW Cheung, T Sahoo, TH Bui, W Bi, X Lu   +54 more
core   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

ESF-EMBO symposium "molecular biology and innovative therapies in sarcomas of childhood and adolescence" Sept 29–Oct 4, Polonia Castle Pultusk, Poland [PDF]

, 2013
Rhabdomyosarcoma (RMS) and Ewing sarcoma (ES) are among the most common pediatric sarcomas (Arndt et al., 2012). Despite sarcomas representing a highly heterogeneous group of tumors, ES and alveolar RMS (ARMS) typically share one common genetic ...
Fulda, Simone, Koscielniak, Ewa, Kovar, Heinrich, Schäfer, Beat W.   +3 more
core   +2 more sources

HMGB2–RAD21 Axis Promotes Fibro/Adipogenic Progenitor Proliferation and Regulates Fat Infiltration

Advanced Science, EarlyView.
This study constructed the first developmental atlas of embryonic skeletal muscle fibro/adipogenic progenitors (FAPs) and identified an HMGB2+ FAPs subpopulation that regulates FAP pool size and muscle homeostasis. HMGB2 directly targets the RAD21 promoter, and its knockout significantly reduces FAP numbers, thereby lowering the potential for ...
Xian Tong, Ziyun Liang, Tianqi Duo, Liping Pan, Qi Zhu, Jiete Liang, Xianyao Luo, Qingcai Feng, Rong Xu, Yihao Liu, Xu Chen, Luxi Chen, Xiaohong Liu, Yaosheng Chen, Delin Mo   +14 more
wiley   +1 more source

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science, EarlyView.
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
wiley   +1 more source

A case report of Monosomy 21 [PDF]

Journal of Kerman University of Medical Sciences, 1999
monosomy 21 is a rare chromosomal abnormality which is persented in mosaic or homogenous forms.the latter form which is very rare,is determined by intra uterin growth retardation)IUGR),failure to thrive (FTT),prominent craniofacial,skeletal deformities ...
M.H Daei-Parizi, M.H Karininejhad, M GHorbanianfard   +2 more
doaj  

Hydatidiform Mole-Between Chromosomal Abnormality, Uniparental Disomy and Monogenic Variants: A Narrative Review. [PDF]

Life (Basel), 2023
Florea A, Caba L, Grigore AM, Antoci LM, Grigore M, Gramescu MI, Gorduza EV.   +6 more
europepmc   +1 more source