Results 121 to 130 of about 231,455 (290)

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Chromosomal Abnormalities in Lymphoma [PDF]

BMJ, 1965
A S, SPIERS, A G, BAIKIE
openaire   +2 more sources

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

Chromosomal abnormalities and mental illness

, 2003
Linkage studies of mental illness have provided suggestive evidence of susceptibility loci over many broad chromosomal regions. Pinpointing causative gene mutations by conventional linkage strategies alone is problematic.
MacIntyre, D J, Pickard, B S, Blackwood, D H R, Porteous, D J, Muir, W J   +4 more
core   +2 more sources

Chronic lymphocytic leukemia-associated chromosomal abnormalities and miRNA deregulation

, 2012
Yvonne Kiefer1, Christoph Schulte2, Markus Tiemann2, Joern Bullerdiek11Center for Human Genetics, University of Bremen, Bremen, Germany; 2Hematopathology Hamburg, Hamburg, GermanyAbstract: Chronic lymphocytic leukemia is the most common leukemia in ...
Bullerdiek J, Schulte C, Kiefer Y, Tiemann M   +3 more
core  

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

The Chromosomal Abnormality of Failed Fertilized Human Oocytes in an In Vitro Fertilization Program

, 2008
Background: The high fertilization failure after IVF treatment cycles could be related to chromosomal abnormalities. This study was carried out to assess the frequency of chromosomal abnormality on human oocytes lacking signs of fertilization 18-20 h ...
Ebrahimi, Ahmad, Solimani, Mehrdad, Fazli, Hossein, Kalnatarh, Seyed M.   +3 more
core   +2 more sources

Trisomy 19 as the sole chromosomal abnormality in proliferative chronic myelomonocytic leukemia

, 2006
Distinct morphologic and clinical features associated with specific chromosomal abnormalities have been described in subgroups of myelodysplastic syndromes (MDS), which often are losses or gains and only rarely translocations.
Johansson, Bertil,, A. Schmitt graff, Johansson, B., Müller-Berndorff, Hendrik, H. Muller berndorff, Kunzmann, R., M. Daskalakis, Mueller-Berndorff, H., B. Johansson, F. Onida, Daskalakis, M., K. Bouabdallah, M. Lubbert, Mauritzson, N., Schmitt-Gräff, Annette, Onida, Francesco, Bouabdallah, K., Mauritzson, Nils, Kunzmann, Regina, Johansson, Bertil, Daskalakis, Michael, Lübbert, Michael, Mauritzson, Nils,, Luebbert, M., Schmitt-Graeff, A., Bouabdallah, Krimo, Lund University., Onida, F., N. Mauritzson, R. Kunzmann   +29 more
core   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

The 5q– Abnormality

, 1987
LOSS OF A PORTION of the long arm of chromosome 5 is seen predominantly in therapy-related myelodysplastic syndromes and acute leukemias, as well as in a unique clinical disorder known as the 5q– syndrome.
Nimer, Stephen D, Golde, David W
core   +1 more source