Results 271 to 280 of about 93,154 (303)

Chromosome Instability on Children with Asthma

Journal of Asthma, 2009
Asthma is a complex disease with multiple interactions between genetic and environmental factors.The aim of our study was to investigate the possible genetic instability in asthmatic patients (AP) with asthma in human cultured peripheral blood lymphocytes.
Theodore, Lialiaris, Aggeliki, Polyzou, Panagiotis, Mpountoukas, Anthi, Tsiggene, Alexandros, Kouskoukis, Stamatia, Pouliliou, Emmanouil, Paraskakis, Ioannis, Tentes, Grigorios, Trypsianis, Athanasios, Chatzimichail   +9 more
openaire   +2 more sources

Chromosome Breaks and Genomic Instability

Cancer Investigation, 2000
Tumorigenesis is known to result from multiple genetic changes. Although endogenous and environmental insults can damage DNA, cellular mechanisms exist to repair various forms of damage or to kill those cells irreparably damaged. Hence, the accumulation of numerous genetic changes that would lead to cancer in normal cells is extremely rare ...
openaire   +2 more sources

Instability at Chromosomal Fragile Sites

1998
Chromosomal fragile sites are loci that are especially prone to forming gaps or breaks on metaphase chromosomes when cells are cultured under conditions that inhibit DNA replication or repair. The relationship of "rare" folate sensitive fragile sites with (CCG)n expansion and, in some cases, genetic disease is well established.
openaire   +2 more sources

Epigenetic drivers of chromosomal instability

Trends in Cancer
Chromosomal instability (CIN) fuels phenotypic cancer heterogeneity through heritable epigenetic defects, hence driving disease initiation, progression, and resistance to therapy. Two recent studies, by Bai et al. and Salinas-Luypaert et al., demonstrate that imbalanced histone or DNA methylation actively promotes CIN by disrupting centrosome ...
Ilio Vitale, Matteo Cereda, Lorenzo Galluzzi   +2 more
openaire   +2 more sources

Chromosomal instability and aneuploidy as causes of cancer drug resistance

Trends in Cancer, 2022
Jason M Sheltzer
exaly  

Spontaneous chromosomal instability

Humangenetik, 1972
openaire   +2 more sources

Aging and chromosomal instability

2005
M, Hirsch-Kauffmann, M, Schweiger
openaire   +2 more sources

Chromosomal instability

Nature, 1992
Laure Sabatier, Bernard Dutrillaux, Maria Berta Martin   +2 more
openaire   +1 more source

Chromosomal Instability in Gastric Cancer: Role in Tumor Development, Progression, and Therapy

International Journal of Molecular Sciences, 2023
Marina V Nemtsova, Ekaterina B Kuznetsova, Irina V Bure   +2 more
exaly  

Mechanisms leading to chromosomal instability

Seminars in Cancer Biology, 2005
Susanne M Gollin
exaly