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Lysosomal degradation ensures accurate chromosomal segregation to prevent chromosomal instability [PDF]
Autophagy, 2021 Lysosomes, as primary degradative organelles, are the end-point of different converging pathways including macroautophagy. To date, lysosome degradative function has been mainly studied in interphase cells, while their role during mitosis remains ...
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Defining ‘chromosomal instability’
Trends in Genetics, 2008Most scientists agree that the majority of human solid malignant tumors are characterized by chromosomal instability (CIN) involving gain or loss of whole chromosomes or fractions of chromosomes. CIN is thought to be an early event during tumorigenesis and might therefore be involved in tumor initiation.
Jochen B, Geigl +3 more
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Telomeres and chromosomal instability
Cellular and Molecular Life Sciences (CMLS), 2004Telomeres are distinctive structures, composed of a repetitive DNA sequence and associated proteins, which enable cells to distinguish chromosome ends from DNA double-strand breaks. Telomere alterations, caused by replication-mediated shortening, direct damage or defective telomere-associated proteins, usually generate chromosomal instability, which is
N, Mathieu +4 more
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Chromosome Instability Syndromes
1989The chromosome instability syndromes represent a group of heritable disorders that share the common characteristics of increased spontaneous or induced chromosome breakage, hypersensitivity to various physical and chemical agents, and a predisposition to the development of neoplasia. Each syndrome has a distinct phenotype, although significant clinical
M M, Cohen, H P, Levy
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Current Opinion in Oncology, 2004
This review discusses numerical and structural chromosomal instability in cancer cells and its possible etiologies, highlighting the recent literature.Defects in chromosomal segregation, telomere stability, and the DNA damage response play significant roles in chromosomal instability in cancer.The pace of discoveries into the biologic basis of ...
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This review discusses numerical and structural chromosomal instability in cancer cells and its possible etiologies, highlighting the recent literature.Defects in chromosomal segregation, telomere stability, and the DNA damage response play significant roles in chromosomal instability in cancer.The pace of discoveries into the biologic basis of ...
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Independent Mechanisms Lead to Genomic Instability in Hodgkin Lymphoma: Microsatellite or Chromosomal Instability [PDF]
Cancers, 2018 International audienceBackground: Microsatellite and chromosomal instability have been investigated in Hodgkin lymphoma (HL). Materials and Methods: We studied seven HL cell lines (five Nodular Sclerosis (NS) and two Mixed Cellularity (MC)) and patient ...
Bruno Colicchio +2 more
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Chromosomal instability in bladder cancer
Archives of Toxicology, 2008Chromosomal instability (CIN) distinguishes invasive urothelial carcinomas from less malignant papillary subtypes. Recent results implicate checkpoint dysfunction as a crucial factor underlying the emergence of aneuploidy in urothelial carcinogenesis. It may moreover contribute to DNA repair defects.
Andrea R, Florl, Wolfgang A, Schulz
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AUTOIMMUNE DISEASE AND CHROMOSOMAL INSTABILITY
The Lancet, 1967Abstract The chromosomes of cultured peripheral blood of fifteen patients with various autoimmune diseases and fifteen control patients matched for age and sex were examined in cultures made under identical conditions. There was no significant difference in chromosomal aneuploidy, breakage, or rearrangement between the two groups of patients.
T, Israsena, A C, Quatrale, K L, Becker
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Mechanisms of chromosome instability in cancers
Critical Reviews in Oncology/Hematology, 2006Most tumours arise through clonal selection and waves of expansion of a somatic cell that has acquired genetic alterations in essential genes either controlling cell death or cell proliferation. Furthermore, stability of the genome in cancer cells becomes precarious and compromised because several cancer-predisposing mutations affect genes that are ...
Jefford Charles Edward +1 more
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Instability of the maize B chromosome
Theoretical and Applied Genetics, 1973The B (9) chromosome of maize exhibits a very ordered type of instability at the second pollen mitosis, when nondisjunction may reach a level of 95%. Much less commonly the chromosome is unstable during early development of the kernel. Instability in the kernel produces recessive sectors in either the endosperm or the sporophyte, reflecting the absence
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