Results 241 to 250 of about 157,687 (296)

Chromosomal Instability Is Associated with cGAS-STING Activation in EGFR-TKI Refractory Non-Small-Cell Lung Cancer. [PDF]

Cells
Yonesaka K, Kurosaki T, Tanizaki J, Kawakami H, Tanaka K, Maenishi O, Takamura S, Sakai K, Chiba Y, Teramura T, Goto H, Otsuka E, Okida H, Funabashi M, Hashimoto Y, Hirotani K, Kamai Y, Kagari T, Nishio K, Kakimi K, Hayashi H.   +20 more
europepmc   +1 more source

LINC01235 Promotes Clonal Evolution through DNA Replication Licensing-Induced Chromosomal Instability in Breast Cancer. [PDF]

Adv Sci (Weinh)
Zhang Q, Wang X, Shao Z, Zhang Y, Zhang L, Chen M, Zhou X, Zhu H, Zhou Y, Lu X, Li P, Chi W, Li L, Shao ZM, Huang S, Xue J, Chi Y, Wu J, Xiu B.   +18 more
europepmc   +1 more source

Chromosomal instability by low-coverage whole-genome sequencing assay predicts prognosis in bladder cancer patients underwent radical cystectomy. [PDF]

BMC Med Genomics
Ding Q, Zhu H, Fan B, Wang L, Jin X, Cao C, Shi Y, Fan Z, Tu W, Li F.   +9 more
europepmc   +1 more source

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Defining ‘chromosomal instability’

Trends in Genetics, 2008
Most scientists agree that the majority of human solid malignant tumors are characterized by chromosomal instability (CIN) involving gain or loss of whole chromosomes or fractions of chromosomes. CIN is thought to be an early event during tumorigenesis and might therefore be involved in tumor initiation.
Jochen B, Geigl, Anna C, Obenauf, Thomas, Schwarzbraun, Michael R, Speicher   +3 more
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Chromosome Instability Syndromes

1989
The chromosome instability syndromes represent a group of heritable disorders that share the common characteristics of increased spontaneous or induced chromosome breakage, hypersensitivity to various physical and chemical agents, and a predisposition to the development of neoplasia. Each syndrome has a distinct phenotype, although significant clinical
M M, Cohen, H P, Levy
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Chromosomal Instability

Current Opinion in Oncology, 2004
This review discusses numerical and structural chromosomal instability in cancer cells and its possible etiologies, highlighting the recent literature.Defects in chromosomal segregation, telomere stability, and the DNA damage response play significant roles in chromosomal instability in cancer.The pace of discoveries into the biologic basis of ...
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Telomeres and chromosomal instability

Cellular and Molecular Life Sciences (CMLS), 2004
Telomeres are distinctive structures, composed of a repetitive DNA sequence and associated proteins, which enable cells to distinguish chromosome ends from DNA double-strand breaks. Telomere alterations, caused by replication-mediated shortening, direct damage or defective telomere-associated proteins, usually generate chromosomal instability, which is
N, Mathieu, L, Pirzio, M-A, Freulet-Marrière, C, Desmaze, L, Sabatier   +4 more
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Telomeres and chromosome instability

DNA Repair, 2006
Genomic instability has been proposed to play an important role in cancer by accelerating the accumulation of genetic changes responsible for cancer cell evolution. One mechanism for chromosome instability is through the loss of telomeres, which are DNA-protein complexes that protect the ends of chromosomes and prevent chromosome fusion.
openaire   +2 more sources