Results 141 to 150 of about 267,700 (194)
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Chromosomal rearrangement and carcinogenesis
Mutation Research/Reviews in Genetic Toxicology, 1982All carcinogens that have been thoroughly tested have been found to induce some kind of chromosomal rearrangement. Chromosomal rearrangements are associated with a variety of human and rodent cancers and are associated, with in vitro cell transformation.
M, Radman, P, Jeggo, R, Wagner
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Chromosomal rearrangements in lipofibromatosis
Cancer Genetics and Cytogenetics, 2007Lipofibromatosis is a relatively rare pediatric neoplasm, which usually manifests as an ill-defined soft tissue mass involving the upper and lower distal extremities, the trunk, and, less frequently, the head. To date, no cytogenetic abnormalities have been reported in this uncommon neoplasm.
Barton, Kenney +3 more
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Cell, 2011 SummaryChromosomal rearrangements, including translocations, require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are frequently involved in producing leukemias, lymphomas and sarcomas ...
Davide F. Robbiani +2 more
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Computational Prediction of Position Effects of Apparently Balanced Human Chromosomal Rearrangements [PDF]
American Journal of Human Genetics, 2017 Interpretation of variants of uncertain significance, especially chromosomal rearrangements in non-coding regions of the human genome, remains one of the biggest challenges in modern molecular diagnosis. To improve our understanding and interpretation of
Miguel Andrade +2 more
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Rearrangements and chromosomal evolution
Current Opinion in Genetics & Development, 2003Comparisons of the genome sequences of related species suggests varying patterns of chromosomal rearrangements in different evolutionary lineages. In this review, I focus on the quantitative characterization of rearrangement processes and discuss specific inventories that have been compiled to date.
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Rearrangements of chromosome 15 in epilepsy
American Journal of Medical Genetics, 2001AbstractA number of observations point to chromosome 15 as a good candidate to harbor genes involved in epilepsy. This hypothesis is supported by at least two lines of evidence: one is the finding that haploinsufficiency of the 15q11‐q13 region, of maternal origin, is responsible for Angelman syndrome, one of the cardinal manifestations of which is ...
L, Torrisi +3 more
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Rearrangement and inference of chromosome structures
Molecular Biology, 2015The chromosome structure is defined as a set of chromosomes that consist of genes assigned to one of the DNA strands and represented in a circular or linear arrangement. A widely investigated problem is to define the shortest algorithmic path of chromosome rearrangements that transforms one chromosome structure into another.
K Yu, Gorbunov +2 more
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Chromosomal rearrangements in bladder cancer
Urology, 1984Description des nouvelles techniques cytogenetiques d'etude des tumeurs solides des aberrations chromosomiques et des oncogenes dans les cellules cancereuses. Etude des rearrangements chromosomiques specifiques dans le cancer de la vessie et de l'importance pronostique du caryotype dans le cancer de la ...
Z, Gibas, A A, Sandberg
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Chromosome Rearrangements and Transposable Elements
Annual Review of Genetics, 2002▪ Abstract There has been limited corroboration to date for McClintock's vision of gene regulation by transposable elements (TEs), although her proposition on the origin of species by TE-induced complex chromosome reorganizations in combination with gene mutations, i.e., the involvement of both factors in relatively sudden formations of species in ...
Wolf-Ekkehard, Lonnig, Heinz, Saedler
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Chromosome rearrangements in trypanosoma brucei
Cell, 1984We have studied chromosome rearrangements in T. brucei using pulsed field gradient gel electrophoresis to separate chromosome-sized DNA molecules. We detect size changes in a set of small chromosomes (200-700 kb) at a frequency of 10(-5) to 10(-6) per trypanosome division; this results in a radical difference in the size distribution of these ...
L H, Van der Ploeg +3 more
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