Results 231 to 240 of about 982,148 (390)

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Optical genome mapping enhances cytogenetic analysis in recurrent miscarriage: confirmation of a suspected (1;10) chromosomal translocation. [PDF]

Mol Cytogenet
Del Águila MDM, Bernal M, Vílchez JR, Romero B, Castilla JA, Álvarez G, Clavero A, Poyatos A, Ruíz-Cabello F.   +8 more
europepmc   +1 more source

SEX CHROMOSOME TRANSLOCATIONS IN THE EVOLUTION OF REPRODUCTIVE ISOLATION

, 1972
Martin L. Tracey
openalex   +2 more sources

Immunoglobulin gene rearrangements and expression in diffuse histiocytic lymphomas reveal cellular lineage, molecular defects, and sites of chromosomal translocation [PDF]

, 1986
KA Siminovitch, JP Jensen, AL Epstein, S J Korsmeyer   +3 more
openalex   +1 more source

Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture

International Journal of Cancer, EarlyView.
Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert, Claire Vargas, Sina Jasmin Wille, Karsten Rippe   +3 more
wiley   +1 more source

Three annotated chromosome-level de novo genome assemblies of Lomentospora prolificans provide evidence for a chromosomal translocation event. [PDF]

G3 (Bethesda)
Grossman NT, Fan Y, Zimin AV, Wear MP, Jedlicka A, Dziedzic A, Liporagi-Lopes LC, Timp W, Casadevall A.   +8 more
europepmc   +1 more source

Epigenetic reprogramming in multiple myeloma—Challenges and opportunities

International Journal of Cancer, EarlyView.
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar, Lev M. Kats, Emily Gruber   +2 more
wiley   +1 more source

Coexistence of acute myeloid leukemia with a complex chromosomal translocation and monoclonal gammopathy of undetermined significance: A case report and literature review. [PDF]

Oncol Lett
Qiao X, Geng L, Tian T, Zhang J, Guo X, Qiao S.   +5 more
europepmc   +1 more source

The chromosome 14 breakpoint in neoplastic B cells with the t(11;14) translocation involves the immunoglobulin heavy chain locus. [PDF]

, 1984
Jan Erikson, J Finan, Yuji Tsujimoto, Peter C. Nowell̀, Carlo M. Croce   +4 more
openalex   +1 more source

Blood‐based biomarkers in soft tissue sarcoma: Implications for immune checkpoint inhibitor therapy

International Journal of Cancer, EarlyView.
Abstract Soft tissue sarcoma (STS) is a rare and heterogeneous cancer, comprising approximately 1% of all adult cancers and 7%–15% of all childhood cancers. In the advanced stages, chemotherapy remains the standard‐of‐care, but efficacy is limited, with a response rate of 15%–30%, and responses are often short‐lived, with median progression‐free ...
Brie‐Anne Mannah, John J. Park, Su Yin Lim   +2 more
wiley   +1 more source