Results 181 to 190 of about 21,431 (261)

XChrom: A Cross‐Cell Chromatin Accessibility Prediction Model Integrating Genomic Sequence and Cellular Context

Advanced Science, EarlyView.
XChrom is a deep learning framework that integrates genomic sequence and single‐cell context to predict chromatin accessibility. It generalizes to unseen cells and genomic regions, enabling cross‐sample and cross‐species analysis. Applied to COVID‐19 patient data, XChrom reveals key transcriptional regulatory mechanisms and disease‐associated ...
Yuanyuan Miao, Xuan Liang, Wenwen Zhang, Dongmei Han, Yurun Li, Zhen Wang   +5 more
wiley   +1 more source

Characterizing a murine breast cancer mouse model reveals chromosomal abnormalities in structure and number of single-cell clones and the presence of rare cancer stem cell-like phenotypes. [PDF]

Animal Model Exp Med
Le QV, Kocsis ZS, Liang S, Li Y, Gliddon BL, Bailey S, Nguyen AT, Turnbull T, Pitson SM, Jurányi Z, Le H, Kempson I.   +11 more
europepmc   +1 more source

Ischemic Postconditioning Protects Aged Myocardium Against Ischemia/Reperfusion Injury by Regulating Mitochondrial Dynamics via piR‐4913

Advanced Science, EarlyView.
A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Xiangyu Zhao, Yanchun Li, Nan Li, Juan Zhang, Xiaolong Ma, Fei Yang, Ruihan Long, Yining Tian, Yichen Wang, Shengchao Ma, Huiping Zhang, Yideng Jiang   +11 more
wiley   +1 more source

Nutritional Value and Food Safety Assessment of Single-Cell Protein Derived from <i>Ralstonia eutropha</i> for Food Applications. [PDF]

Foods
You X, Zhang L, Chen L, Wang H, Zou H, Zhu Z, Zhao G.   +6 more
europepmc   +1 more source

Amcinonide Exhibits Antitumor Effects in Radioresistant Colorectal Cancer Through the circRNF10/miR‐296‐5p/Snail Axis

Advanced Science, EarlyView.
Amcinonide (AMC), the FDA‐approved corticosteroid, was identified as a repurposed agent for radiation‐resistant colorectal cancer. AMC suppresses radiation‐induced epithelial–mesenchymal transition, migration, and invasion via the circRNF10/miR‐296‐5p/Snail axis.
Hyun Jeong Seok, Dong Hyeon Lee, Junhye Kwon, Ui Sup Shin, In Hwa Bae   +4 more
wiley   +1 more source

Previously unreported translocation (14;15)(q32; q11.2) observed in B-cell acute lymphoblastic leukemia: a case report. [PDF]

Mol Cytogenet
Naz M, Hassan J, Mansoor N.
europepmc   +1 more source

An Integrated Framework Coupling Hierarchical Hyperspectral i‐trait Screening, Gene Identification, and Functional Validation for Genetic Dissection of Salt Tolerance in Cotton

Advanced Science, EarlyView.
An integrated phenomics–genomics framework captures dynamic salt‐stress responses in laboratory‐grown cotton seedlings through time‐series hyperspectral imaging and non‐destructive i‐trait extraction. Hierarchical screening identifies biologically relevant, heritable, and non‐redundant traits for high‐resolution GWAS, identifying GhST7.
Bowei Xu, Le Liu, Mengli Yu, Yuling Guo, Junli Ye, Jun Zhang, Rumeng Zhao, Jiajie Yang, Wanneng Yang, Yameng Xu, Liqiang Fan, Zuoren Yang   +11 more
wiley   +1 more source

The clinical relevance of sole loss of chromosome Y in myeloid neoplasms. [PDF]

Blood Cancer J
Huber S, Hutter S, Meggendorfer M, Pohlkamp C, Haferlach T, Summerer I.   +5 more
europepmc   +1 more source

3′‐UTR Hypermethylation and ABA Signaling Coordinate Transcriptional Activation of SWEET14 for High Sugar Accumulation in Citrus

Advanced Science, EarlyView.
Hypermethylation of CliSWEET14 3′‐UTR relieves ClibHLH105‐mediated transcriptional repression, together with ABA signaling‐mediated activation of the CliABF3‐CliNAC56 cascade, boosts CliSWEET14 expression and sucrose accumulation in citrus. ABSTRACT Sugar accumulation is pivotal for fruit quality, yet the molecular regulation of this process remains ...
Yike Zeng, Yue Wang, Yilei Wang, Haowei Chen, Qiyu Chen, Wei Xiao, Aoqing Zhang, Xin Jiang, Xiangming Shang, Zhicheng Yang, Xi Zeng, Wenqiang Hu, Chunlong Li, Ji‐Hong Liu   +13 more
wiley   +1 more source

FISH-Dist: An Automated Pipeline for 3D Genomic Spatial Distance Quantification in FISH Imaging. [PDF]

Bioengineering (Basel)
Aigouy B, Caturegli E, Charroux B, Martins CS, Gregor T, Prud'homme B.   +5 more
europepmc   +1 more source