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Genotoxicity assessment of chemical mixtures [PDF]

EFSA Journal, 2019
The EFSA Scientific Committee addressed in this document the peculiarities related to the genotoxicity assessment of chemical mixtures. The EFSA Scientific Committee suggests that first a mixture should be chemically characterised as far as possible ...
EFSA Scientific Committee, Simon More, Vasileios Bampidis, Diane Benford, Jos Boesten, Claude Bragard, Thorhallur Halldorsson, Antonio Hernandez‐Jerez, Susanne Hougaard‐Bennekou, Kostas Koutsoumanis, Hanspeter Naegeli, Søren Saxmose Nielsen, Dieter Schrenk, Vittorio Silano, Dominique Turck, Maged Younes, Gabriele Aquilina, Riccardo Crebelli, Rainer Gürtler, Karen Ildico Hirsch‐Ernst, Pasquale Mosesso, Elsa Nielsen, Roland Solecki, Maria Carfì, Carla Martino, Daniela Maurici, Juan Parra Morte, Josef Schlatter   +27 more
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Rapid and Accurate Genotoxicity Assessment Using the Neutral Comet Assay in Cyprinus carpio Cells

Life
Genotoxins cause significant damage to the genetic material of aquatic organisms, requiring rapid and accurate assessment. Fish-derived cells sensitive to genotoxins have proven to be a useful tool for measuring genotoxicity, but the long treatment times
Byeonghyeon So, Ji Ho Park, Minseon Kim, Hojun Lee, Jee Hee Yoon, Yoo Jin Lee, Duyeol Kim, Hyung Wook Kwon, Jihae Park, Taejun Han, Yun Haeng Lee, Joon Tae Park   +11 more
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Mechanisms and Assessment of Genotoxicity of Metallic Engineered Nanomaterials in the Human Environment

Biomedicines
Engineered nanomaterials (ENMs) have a broad array of applications in agriculture, engineering, manufacturing, and medicine. Decades of toxicology research have demonstrated that ENMs can cause genotoxic effects on bacteria, mammalian cells, and animals.
Benjamin M. Liu, A. Wallace Hayes
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Allium test genotoxicity data on water from river valley of Irtysh, West Siberia

Data in Brief, 2022
Assessment of genotoxicity of aquatic ecosystems is of great importance for environmental management and assessment of water ecological quality as well as health safety.Data on the genotoxicity of water in rivers of such a large region as Siberia are ...
Dmitry S. Pesnya, Sergey E. Bolotov
doaj   +1 more source

Scientific opinion on the renewal of the authorisation of proFagus Smoke R709 (SF‐008) as a smoke flavouring Primary Product

EFSA Journal, 2023
The EFSA Panel on Food Additives and Flavourings (FAF) was requested to evaluate the safety of the smoke flavouring Primary Product proFagus Smoke R709 (SF‐008), for which a renewal application was submitted in accordance with Article 12(1) of Regulation
EFSA Panel name on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Gisela Degen, Karl‐Heinz Engel, Paul J Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Ursula Gundert‐Remy, Rainer Gürtler, Trine Husøy, Melania Manco, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Matthew Wright, Romualdo Benigni, Polly Boon, Claudia Bolognesi, Eugenia Cordelli, Kevin Chipman, Gisela Degen, Ullrika Sahlin, Maria Carfì, Carla Martino, Agnieszka Mech, Salvatore Multari, Vasantha Palaniappan, Alexandra Tard, Wim Mennes   +31 more
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Genotoxic and antigenotoxic medicinal plant extracts and their main phytochemicals: “A review”

Frontiers in Pharmacology
Many medicinal plant extracts have been proven to have significant health benefits. In contrast, research has shown that some medicinal plant extracts can be toxic, genotoxic, mutagenic, or carcinogenic.
Ghanya Al-Naqeb, Ghanya Al-Naqeb, Aliki Kalmpourtzidou, Francesca Giampieri, Francesca Giampieri, Rachele De Giuseppe, Hellas Cena, Hellas Cena   +7 more
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Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster

Genetics and Molecular Biology, 2014
The genotoxicity of bloom head (BHE) and leaf (LE) extracts from artichoke (Cynara scolymus L.), and their ability to modulate the mutagenicity and recombinogenicity of two alkylating agents (ethyl methanesulfonate - EMS and mitomycin C - MMC) and the ...
Laura Vicedo Jacociunas, Rafael Rodrigues Dihl, Mauricio Lehmann, Alexandre de Barros Falcão Ferraz, Marc François Richter, Juliana da Silva, Heloísa Helena Rodrigues de Andrade   +6 more
doaj   +1 more source

A comparative genotoxicity study of a supraphysiological dose of triiodothyronine (T₃) in obese rats subjected to either calorie-restricted diet or hyperthyroidism. [PDF]

PLoS ONE, 2013
This study was designed to determine the genotoxicity of a supraphysiological dose of triiodothyronine (T3) in both obese and calorie-restricted obese animals.
Maria Teresa De Sibio, Renata Azevedo Melo Luvizotto, Regiane Marques Castro Olimpio, Camila Renata Corrêa, Juliana Marino, Miriane de Oliveira, Sandro José Conde, Ana Lúcia dos Anjos Ferreira, Carlos Roberto Padovani, Célia Regina Nogueira   +9 more
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Summarized data of genotoxicity tests for designated food additives in Japan

Genes and Environment, 2018
The Ministry of Health, Labour and Welfare has carried out genotoxicity tests for food additives used in Japan in cooperation with the Japan Food Additives Association since 1979. Hayashi et al.
Masami Yamada, Masamitsu Honma
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Few-layer graphene induces both primary and secondary genotoxicity in epithelial barrier models in vitro

Journal of Nanobiotechnology, 2021
Background Toxicological evaluation of engineered nanomaterials (ENMs) is essential for occupational health and safety, particularly where bulk manufactured ENMs such as few-layer graphene (FLG) are concerned.
Michael J. Burgum, Martin J. D. Clift, Stephen J. Evans, Nicole Hondow, Afshin Tarat, Gareth J. Jenkins, Shareen H. Doak   +6 more
doaj   +1 more source