Results 41 to 50 of about 65,731 (278)

Nanomaterial genotoxicity evaluation using the high-throughput p53-binding protein 1 (53BP1) assay.

PLoS ONE, 2023
Toxicity evaluation of engineered nanomaterials is challenging due to the ever increasing number of materials and because nanomaterials (NMs) frequently interfere with commonly used assays.
Maelle Fontaine, Eline Bartolami, Marion Prono, David Béal, Magda Blosi, Anna L Costa, Costanza Ravagli, Giovanni Baldi, Simone Sprio, Anna Tampieri, Ivana Fenoglio, Lang Tran, Bengt Fadeel, Marie Carriere   +13 more
doaj   +1 more source

Comparative Evaluation of Genotoxicity of Captan in Amphibian Larvae (Xenopus laevis and Pleurodeles waltl) Using the Comet Assay and the Micronucleus Test [PDF]

, 2006
Captan (N-trichloromethylthio-4-cyclohexene-1,2-dicarboximide) is a fungicide used to inhibit the growth of many types of fungi on plants used as foodstuffs.
Gauthier, Laury, Devaux, Alain, Gauthier, L., Mouchet, F., Ferrier, V., Mouchet, Florence, Ferrier, Vincent, Mailhes, Corinne, Devaux, A.   +8 more
core   +1 more source

Is the Comet Assay a Sensitive Procedure for Detecting Genotoxicity?

Journal of Nucleic Acids, 2010
Although the Comet assay, a procedure for quantitating DNA damage in mammalian cells, is considered sensitive, it has never been ascertained that its sensitivity is higher than the sensitivity of other genotoxicity assays in mammalian cells. To determine
Satomi Kawaguchi, Takanori Nakamura, Ayumi Yamamoto, Gisho Honda, Yu F. Sasaki   +4 more
doaj   +1 more source

A Novel Strategy to Predict Carcinogenicity of Antiparasitics Based on a Combination of DNA Lesions and Bacterial Mutagenicity Tests

Frontiers in Public Health, 2017
Genotoxicity and carcinogenicity testing of pharmaceuticals prior to commercialization is requested by regulatory agencies. The bacterial mutagenicity test was considered having the highest accuracy of carcinogenic prediction.
Qianying Liu, Zhixin Lei, Feng Zhu, Awais Ihsan, Xu Wang, Zonghui Yuan, Zonghui Yuan, Zonghui Yuan   +7 more
doaj   +1 more source

Genotoxicity of nitroso compounds and sodium dichromate in a model combining organ cultures of human nasal epithelia and the comet assay [PDF]

, 2001
Genotoxic effects of xenobiotics are a possible step in tumor initiation in the mucosa of the upper aerodigestive tract. Using the comet assay, detecting genotoxicity in human tissue has been restricted to single incubations in vitro, but in vivo most ...
Bergner, Albrecht, Kastenbauer, Ernst R., Gamarra, Fernando, Kleinsasser, Norbert H., Harréus, Ulrich A., Huber, Rudolf M., Wallner, Barbara C., Juchhoff, Jutta   +7 more
core   +1 more source

Evaluation of genotoxicity induced by endodontic materials: A systematic review

Saudi Endodontic Journal, 2022
The ability of a substance to cause harm to the DNA molecule is known as genotoxicity. Because there is significant evidence of link between genetic damage and carcinogenesis, determining the real health hazards to patients and dental workers requires a ...
Sadaf Tamanna, Huma Iftekhar, Asmat Fatima, Aaliya Rehman   +3 more
doaj   +1 more source

The genotoxicity of caecal water from gilts following experimentally induced Fusarium mycotoxicosis

Veterinární Medicína, 2015
The examination of caecal contents allows one to investigate the exposure of colon mucosa to dietary toxins and the chemical contaminants present in animal feed.
A. Nowak, K. Slizewska, M. Gajecka, M. Piotrowska, Z. Zakowska, L. Zielonka, M. Gajecki   +6 more
doaj   +1 more source

Thresholds of Genotoxic and Non-Genotoxic Carcinogens

Toxicological Research, 2018
Exposure to chemical agents is an inevitable consequence of modern society; some of these agents are hazardous to human health. The effects of chemical carcinogens are of great concern in many countries, and international organizations, such as the World Health Organization, have established guidelines for the regulation of these chemicals. Carcinogens
openaire   +3 more sources

Toxicological impact of polyvinyl chloride microplastic-contaminated food: Evidence from a mouse model

Emerging Contaminants
Microplastic pollution has emerged as a critical environmental and public health concern, induced by the widespread presence and toxicity of various polymers across diverse environments, food systems, and animal bodies.
Mahzabin Muzahid Labi, Mahmuda Begum, Mohammad Firoj Jaman, Shofiul Alam, Md Nasir Uddin, Shanzida Islam, Nahid Sultana, Md Mizanur Rahman   +7 more
doaj   +1 more source

Genotoxicity evaluation of medical devices: A regulatory perspective [PDF]

, 2021
This review critically evaluates our current regulatory understanding of genotoxicity testing and risk assessment of medical devices. Genotoxicity risk assessment of these devices begins with the evaluation of materials of construction, manufacturing ...
Jha, Awadhesh N., Murugan, Sivasubramanian, Sathya, Tiruvathipuram N., Yogaraj, Desikan, Navaneethakrishnan, K. R., Murali, Malliga R., Balaje, Ramalingam, Pradeepa, Pitchaipillai, Kumaravel, Tirukalikundram S., Sivasubramanian Murugan, Malliga R. Murali, Desikan Yogaraj, K.R. Navaneethakrishnan, Tirukalikundram S. Kumaravel, Tiruvathipuram N. Sathya, Awadhesh N. Jha, Ramalingam Balaje, Pitchaipillai Pradeepa   +17 more
core   +1 more source