Results 51 to 60 of about 65,731 (278)

Acute immobilization assay with Daphnia similis: A miniaturized protocol

NAM Journal
To reduce volume of samples, residues, costs and time, ecotoxicologists are seeking for new approach methodologies. Miniaturized versions of already well-established protocols are arising as a promising tool to diminish costs and residues in the ...
João Gabriel Mesquita Silva, Gabriela Russi de Oliveira, Ádria Caloto de Oliveira, Anjaina Fernandes de Albuquerque, Francine Inforçato Vacchi, Paula Suares-Rocha, Gisela de Aragão Umbuzeiro   +6 more
doaj   +1 more source

Common Considerations for Genotoxicity Assessment of Nanomaterials

Frontiers in Toxicology, 2022
Genotoxicity testing is performed to determine potential hazard of a chemical or agent for direct or indirect DNA interaction. Testing may be a surrogate for assessment of heritable genetic risk or carcinogenic risk.
Rosalie K. Elespuru, Shareen H. Doak, Andrew R. Collins, Maria Dusinska, Stefan Pfuhler, Mugimane Manjanatha, Renato Cardoso, Connie L. Chen   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Lead-induced DNA damage in Vicia faba root cells: Potential involvement of oxidative stress [PDF]

, 2011
Genotoxic effects of lead (0–20 µM) were investigated in whole-plant roots of Vicia faba L., grown hydroponically under controlled conditions. Lead-induced DNA damage in V.
Jean, Séverine, Eric Pinelli, Silvestre, Jérôme, Séverine Jean, Pinelli, Eric, Pourrut, Bertrand, Bertrand Pourrut, Jérôme Silvestre   +7 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Scientific Opinion on Flavouring Group Evaluation 213, Revision 2 (FGE.213Rev2): Consideration of genotoxic potential for α,β‐unsaturated alicyclic ketones and precursors from chemical subgroup 2.7 of FGE.19

EFSA Journal, 2015
The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF Panel) of the European Food Safety Authority (EFSA) was requested to evaluate the genotoxic potential of 26 flavouring substances from subgroup 2.7 of FGE.19 in Flavouring
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
doaj   +1 more source

Toxic and genotoxic potential evaluation of soil samples by bioassays

Acta Agriculturae Slovenica, 2005
Soil samples were obtained from Slovenian industrial region Šaleška dolina and aqueous leachates were prepared. The toxicity and genotoxicity potential of these aqueous fractions have been evaluated by in vitro toxicity and genotoxicity bioassays ...
Barbara LAH, Miha AVBERŠEK, Gregor GORJANC, Romana MARINŠEK LOGAR   +3 more
doaj   +1 more source

Controlling disinfection byproducts from treated wastewater using adsorption with granular activated carbon: Impact of pre-ozonation and pre-chlorination

Water Research X, 2020
This study measured chlorine- and chloramine-reactive precursors using formation potential (FP) tests of nine U.S. Environmental Protection Agency (EPA) regulated and 57 unregulated disinfection byproducts (DBPs) in tertiary-filtered wastewater before ...
Edgard M. Verdugo, Mac Gifford, Caitlin Glover, Amy A. Cuthbertson, Rebecca A. Trenholm, Susana Y. Kimura, Hannah K. Liberatore, Susan D. Richardson, Benjamin D. Stanford, R. Scott Summers, Eric R.V. Dickenson   +10 more
doaj   +1 more source

Evaluation of Genotoxicity by the umu-test of Sediment and River Water in Nagasaki, Japan [PDF]

, 2008
Genotoxicities of sediment from three rivers in Nagasaki, Japan were evaluated by the umu-test. The sediment of the Urakami river, which wastewater treatment plant (WTP) effluent flow in, indicated genotoxic activity.
高尾, 雄二, 伊藤, 剛史, 久保, 隆   +2 more
core  

Assessment of the potential in vivo ecotoxicity of Double-Walled Carbon Nanotubes (DWNTs) in water, using the amphibian Ambystoma mexicanum [PDF]

, 2007
Because of their specific properties (mechanical, electrical, etc), carbon nanotubes (CNTs) are being assessed for inclusion in many manufactured products.
Flahaut, Emmanuel, Gauthier, Laury, Landois, Périne, Pinelli, Eric, Mouchet, Florence   +4 more
core   +1 more source