Results 161 to 170 of about 24,510 (263)

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

Interdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang, Fan Zou, Mingdong Wang, Chenyue Wu, Yingwei Xie, Yongjun Quan, Wei Yan, Yupeng Zheng, Lianhua Li, Yuexin Liu, Jian Yu, Hao Ping   +11 more
wiley   +1 more source

Case Report: Deciphering a <i>de novo</i> complex chromosomal rearrangement causing premature ovarian insufficiency, short stature, and mild intellectual disability using long-read sequencing. [PDF]

Front Genet
Cheng Q, Peng Q, Lv F, Zeng X, Chen X, Li S, Lu X.   +6 more
europepmc   +1 more source

Detection and Clinical Significance of Chromosomal Mosaicism in Prenatal Diagnosis: A Retrospective Study From a Prenatal Diagnosis Center

Journal of Clinical Laboratory Analysis, EarlyView.
This retrospective study of 79 prenatal mosaicism cases found that noninvasive prenatal testing (NIPT) had significantly higher sensitivity (90.74%) than first‐ and second‐trimester serum screening, while chromosomal microarray analysis (CMA) showed better concordance with karyotyping (90.00%) than QF‐PCR (58.21%).
Yuanyuan Pei, Xiaojin Luo, Jian Ran, Liang Hu, Weiqiang Liu, Fengxiang Wei   +5 more
wiley   +1 more source

Flying fish as useful model for evolutionary investigations in epipelagic zones. A cytogenomic and cytotaxonomic approach. [PDF]

Comp Cytogenet
da Costa GWWF, Shibatta OA, Cioffi MB, Vidal JAD, Bertollo LAC, Molina WF.   +5 more
europepmc   +1 more source

Chromosomal characterization in two species of an Astyanax bimaculatus complex (Characidae, Characiformes) using different techniques of chromosome banding. [PDF]

Cytotechnology, 2016
Da Silva LL, Dos Santos AR, Giuliano-Caetano L, Dias AL.   +3 more
europepmc   +1 more source

Clinical and Cytogenomic Characterization of Three Patients With Distal 1q43q44 Deletion: Twin Sisters With a de novo Deletion and a Patient With der(1)t(1;21)(q43;q22.3)mat

Journal of Clinical Laboratory Analysis, EarlyView.
Distal 1q43q44 deletions lead to a consistent neurodevelopmental phenotype characterized by microcephaly, corpus callosum abnormalities, and developmental delay. Despite differences in genomic architecture, overlapping deletions affecting dosage‐sensitive genes such as AKT3, HNRNPU, and ZBTB18 define the core phenotype.
Ma. Guadalupe Domínguez‐Quezada, Horacio Rivera, Luis E. Figuera, Patricio Barros‐Núñez, José Luis Castrillo, Carlos Córdova‐Fletes, Thania Alejandra Aguayo‐Orozco   +6 more
wiley   +1 more source

<i>Chironomus</i> sp. J - an elusive species from the <i>Chironomus plumosus</i> (Linnaeus, 1758) sibling-species group (Diptera, Chironomidae). [PDF]

Comp Cytogenet
Golygina VV.
europepmc   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Cytogenomic Investigation of Individuals with Ovotesticular Difference of Sex Development.

Sex Dev
Lima-Santos J, Nascimento-Vidoti CG, Correia-Costa GR, Campos NLV, Guaragna MS, de Oliveira FM, Barros BA, Miranda ML, Antolini Tavares A, Guerra-Junior G, Maciel-Guerra AT, Fabbri-Scallet H, Vieira TP.   +12 more
europepmc   +1 more source

A genetic screen for regulators of Drosophila histone H1 binding and chromosome structure in vivo. [PDF]

Genetics
Siriaco G, Mawla GD, Cutler KE, Fasulo B, Tamkun JW.   +4 more
europepmc   +1 more source