Results 101 to 110 of about 1,497,962 (254)

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Data_Sheet_1_Investigation of the Basic Steps in the Chromosome Conformation Capture Procedure.pdf

, 2021
A constellation of chromosome conformation capture methods (С-methods) are an important tool for biochemical analysis of the spatial interactions between DNA regions that are separated in the primary sequence.
Yulii V. Shidlovskii (3838981), Anna E. Pravednikova (11454502), Oleg V. Bylino (11454496), Airat N. Ibragimov (11454499)   +3 more
core   +1 more source

A maximum likelihood algorithm for reconstructing 3D structures of human chromosomes from chromosomal contact data

BMC Genomics, 2018
Background The development of chromosomal conformation capture techniques, particularly, the Hi-C technique, has made the analysis and study of the spatial conformation of a genome an important topic in bioinformatics and computational biology.
Oluwatosin Oluwadare, Yuxiang Zhang, Jianlin Cheng   +2 more
doaj   +1 more source

Charting Morphotoxicity With Complementary Embryo Models

Advanced Healthcare Materials, EarlyView.
Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Dorian G. Luijkx, Pauline L. Balder, Romy M. L. Verhagen, Vinidhra Shankar, Barry Jutten, Pinak Samal, Timo Rademakers, Clemens A. van Blitterswijk, Stefan Giselbrecht, Erik J. Vrij   +9 more
wiley   +1 more source

Chromosome Conformation in Context [PDF]

, 2017
Chromosome conformation capture (3C) techniques have revealed many features about the structure of chromatin: Large scale organization into two compartments (A and B), relatively stable partitioning into Topologically Associating Domains (TADs) at the ...
Taylor, James
core   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

A chromosome conformation capture ordered sequence of the barley genome [PDF]

, 2017
Cereal grasses of the Triticeae tribe have been the major food source in temperate regions since the dawn of agriculture. Their large genomes are characterized by a high content of repetitive elements and large pericentromeric regions that are virtually ...
Schulman, Alan H., Yin, Sh., Dai, F., Martin Mascher, Shuya Yin, Wicker, Thomas, Lin Li, Zhang, Q., Gundlach, Heidrun, Joanne Russell, Himmelbach, Axel, Bellgard, M. I., Barrero, Roberto, Hedley, P.E., Ramsay, Luke, Han, Yong, Cao, S., Liu, Hui, Jan Vrána, Russell, J.A., Ayling, S., Ljudmilla Borisjuk, Lala Aliyeva-Schnorr, Taudien, S., Close, Timothy J, Tanskanen, J., Ounit, Rachid, Wanamaker, S., Barrero, R., Chengdao Li, Mayer, Klaus, Colmsee, Christian, Lonardi, S., Colmsee, Chr., Hedley, Pete E, Staňková, H., Close, T.J., Uwe Scholz, Gundlach, H., Wicker, Th., Muehlbauer, G. J., Barrero, R.A., Rachid Ounit, Platzer, M., Chan, S., Mayer, Kl. F. X., Heavens, Darren, Hedley, P. E., Jesse A. Poland, Li, Chengdao, Haberer, Georg, Zhou, G., Hana Šimková, Li, C., Muñoz-Amatriaín, M., Bellgard, M.I., Taudien, Stefan, Ilka Braumann, Beier, S., Chapman, Br., Wicker, T., Borisjuk, Lj., Schmutzer, Th., Grasso, St., Spannagl, Manuel, Himmelbach, A., Mayer, Klaus FX, Hansson, Mats, Qisen Zhang, Muehlbauer, G.J., Guoping Zhang, Sampath, Dharanya, Braumann, Ilka, Twardziok, Sven O, Hedley, P., Peter Langridge, Jaakko Tanskanen, Twardziok, S., Mario Caccamo, Russell, J., Chapman, Brett, Ramsay, L., Hansson, M., Dharanya Sampath, Manuel Spannagl, Poland, Jesse A, Fei Dai, Zhang, Xiao-Qi, Aliyeva-Schnorr, L., Spannagl, M., Alan H. Schulman, Matthias Platzer, Leah Clissold, Mascher, M., Matthew I. Bellgard, Schmutzer, T., Hastie, A., Clark, Matthew D, Barrero, R. A., Twardziok, Sv. O., Felder, Marius, Houben, Andreas, Caccamo, M., et al., Zhang, X-Q, Wang, P., Braumann, I., McCooke, John K., Muehlbauer, Gary J, Yong Han, Sarah Ayling, McCooke, J.K., Stein, Nils, Grasso, S., Hastie, Alex, Darren Heavens, Matthew D. Clark, Poland, Jesse A., Haberer, G., Chapman, B., Daniel Bolser, Chongyun Lin, Platzer, Matthias, Li, Ch., Helena Staňková, Chan, S.W., Zhang, Guoping, Wanamaker, St., Doležel, J., Christian Colmsee, Stefano Lonardi, Tanskanen, Jaakko, Sujie Cao, Gary J. Muehlbauer, McCooke, John K, Staňková, Helena, Waugh, Robbie, Aliyeva-Schnorr, Lala, Tan, C., Beier, Sebastian, Chan, Saki, Groth, Marco, Doležel, Jaroslav, Close, Timothy J., et al, Groth, M., John K. McCooke, Ounit, R., Yin, Shuya, Roberto A. Barrero, Mascher, Martin, Li, Lin, Scholz, Uwe, Twardziok, Sven O., Clissold, Leah, Bolser, D., Mayer, K.F.X., Saki Chan, Hui Liu, Luke Ramsay, Li, Xuan, Hua Li, Cong Tan, Poland, Jesse, Lin, C., Scholz, U., Lonardi, St., Penghao Wang, Zhang, X.Q., Langridge, P., Waugh, R., Xuan Li, Xiao-Qi Zhang, Zhang, X., Ayling, Sarah, Vrána, J., Klaus F. X. Mayer, Šimková, Hana, Radchuk, V., Borisjuk, L., Poland, J. A., Alex Hastie, Songbo Wang, Han, Y., Timothy J. Close, Waugh, Robbie; id_orcid, Sampath, Dh., Zhang, G., Dai, Fei, Colmsee, C., Houben, A., McCooke, J. K., Stefano Grasso, Christoph Dockter, Kersey, P., Zhou, Gaofeng, Tan, C.S., Wang, Songbo, Radchuk, Volodymyr, Zhang, X.-Q., Borisjuk, Ljudmilla, Heidrun Gundlach, Li, Hua, Thomas Wicker, Wang, S., Robbie Waugh, Bayer, Micha, Stefan Taudien, Sven O. Twardziok, Nils Stein, Dockter, Chr., Barrero, Roberto A, Schmutzer, Thomas, Wanamaker, Steve, Marco Groth, Gaofeng Zhou, Doleael, Jaroslav, Barrero, Roberto A., Li, L., Lin, Chongyun, Wang, Penghao, Bellgard, Matthew I., Mats Hansson, Schulman, Alan H, Heavens, D., Šimková, H., Twardziok, S.O., Kersey, Paul, Close, T. J., Muehlbauer, Gary J., Dockter, C., Zhang, Xiao Qi, Marius Felder, Muñoz-Amatriaín, María, Jaroslav Doležel, Brett Chapman, Caccamo, Mario, Chailyan, A., Clissold, L., Chailyan, Anna, Grasso, Stefano, Yin, S., Bolser, Daniel, Taudien, St., Andreas Houben, Clark, M. D., Cao, Sujie, Bellgard, Matthew I, Pete E. Hedley, Langridge, Peter, Schulman, A.H., Schulman, Alan, Felder, M., Steve Wanamaker, Russell, Joanne, Clark, M.D., Tan, Cong, Liu, H., Georg Haberer, Volodymyr Radchuk, Sampath, D., Stein, N., Zhang, Qisen, Bayer, M., Micha Bayer, María Muñoz-Amatriaín, Sebastian Beier, Li, X., Poland, J.A., Axel Himmelbach, Clark, Matthew D., Mayer, Klaus F. X., Anna Chailyan, Muñoz-Amatriaín, Aria, Thomas Schmutzer, Vrána, Jan, Dockter, Christoph, Lonardi, Stefano, Hedley, Pete E., Li, H., Lin, Ch., Paul Kersey   +281 more
core   +1 more source

Chromosome-level genome assembly of the Stoliczka’s Asian trident bat (Aselliscus stoliczkanus)

, 2023
Stoliczka’s Asian trident bat (Aselliscus stoliczkanus) is a small-bodied species and is sensitive to climate change. Here, we presented a chromosome-level genome assembly of the Stoliczka’s Asian trident bat (Aselliscus stoliczkanus) by combining ...
Lan Linjing (16788630)
core   +1 more source

HiCeekR: A Novel Shiny App for Hi-C Data Analysis

Frontiers in Genetics, 2019
The High-throughput Chromosome Conformation Capture (Hi-C) technique combines the power of the Next Generation Sequencing technologies with chromosome conformation capture approach to study the 3D chromatin organization at the genome-wide scale. Although
Lucio Di Filippo, Dario Righelli, Miriam Gagliardi, Miriam Gagliardi, Maria Rosaria Matarazzo, Claudia Angelini   +5 more
doaj   +1 more source