Results 191 to 200 of about 20,695 (239)

Neurolathyrism in Sub‐Saharan Africa—Assessing the Neurotoxic Risks of Lathyrus sativus Amid Drought and Food Security Challenges

Food Safety and Health, EarlyView.
Representation of grass pea consumption in drought‐stricken sub‐Saharan Africa sustains nutrition, but excess β‐ODAP exposure due to multiple reasons triggers neurolathyrism, a progressive neurotoxic disorder. ABSTRACT Neurolathyrism is a progressive motor neuron disease due to the consumption of Lathyrus sativus (grass pea) over long periods.
Biruk Demisse Ayalew, Muhammad Umar, Pakeezah Tabasum, Maria Qadri, Talha Farooq, Eskeatnaf Yosef Getachew, Zemichael Getu Alemayehu, Eden Haile Hagos, Hailemariam Shimelis Gebeyehu, Hanna Tsehay Abebe, Nuradin Abdi Ali, David Chinaecherem Innocent, Temesgen Mamo Sharew   +12 more
wiley   +1 more source

A Multi‐Objective Periodic Vehicle Routing Model for Sustainable Healthcare Waste Collection

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT The collection of infectious waste from healthcare facilities (HCF) constitutes a recurring operational challenge. Indeed, despite the inherent health risks posed by the storage and the transportation of infectious materials, most of the existing waste collection systems tends to prioritise cost optimization and to underaddress the safety ...
Hajer Ben‐Romdhane
wiley   +1 more source

Gene signatures characterizing driver mutations in lung squamous carcinoma are predictive of the progression of pre‐cancer lesions

International Journal of Cancer, EarlyView.
What's New? Lung squamous cell carcinoma (LUSC) is more aggressive than lung adenocarcinoma, and is most often diagnosed at an advanced stage. Here, the authors evaluated gene expression data from LUSC tumors and came up with gene signatures for 34 genetic abnormalities whose expression changes throughout different precancerous stages. Several of these
Yupei Lin, Venugopalareddy Mekala, Jianrong Li, Xiang Wang, Muhammad Aminu, Jia Wu, Jianjun Zhang, Robert Taylor Ripley, Christopher I. Amos, Chao Cheng   +9 more
wiley   +1 more source

Chromosome Conformation Capture on Chip (4C)

, 2008
openaire   +1 more source

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Quantitative Chromosome Conformation Capture (3C-qPCR)

Methods in Molecular Biology, 2022
Many population-based methods investigating chromatin dynamics and organization in eukaryotes are based on the chromosome conformation capture (3C) method. Here, we provide an updated version of the quantitative 3C (3C-qPCR) protocol for improved and simplified quantitative analyses of intra-chromosomal contacts.
Thierry Forné, Forné Thierry
exaly   +3 more sources

Chromosome Conformation Capture

Cold Spring Harbor Protocols, 2009
INTRODUCTIONChromosome conformation capture (3C) is a technique used to detect the spatial organization of chromosomal DNA in fixed cells. DNA sequences in spatial proximity in the nucleus or engaged in physical interactions (such as those between genes and regulatory elements) can be assessed quantitatively to provide a measure that potentially ...
Nathan F, Cope, Peter, Fraser
openaire   +2 more sources

Capturing Chromosome Conformation

Science, 2002
We describe an approach to detect the frequency of interaction between any two genomic loci. Generation of a matrix of interaction frequencies between sites on the same or different chromosomes reveals their relative spatial disposition and provides information about the physical properties of the chromatin fiber.
Job, Dekker, Karsten, Rippe, Martijn, Dekker, Nancy, Kleckner   +3 more
openaire   +2 more sources

Chromosome Conformation Capture for Large Genomes

2022
The gigantic 32Gb Axolotl genome inspires fascinating questions such as: how such a big genome is organized and packed in nuclei and how regulation of gene transcription can happen over such large genomic distances. Currently, there are many technical challenges when we investigate chromatin architecture in axolotl.
Akane, Kawaguchi, Elly M, Tanaka
openaire   +2 more sources

Chromosome Conformation Capture of Mitotic Chromosomes

2023
Despite more than a century of intensive study of mitotic chromosomes, their three-dimensional organization remains enigmatic. The last decade established Hi-C as a method of choice for study of spatial genome-wide interactions. Although its utilization has been focused mainly on studying genomic interactions in interphase nuclei, the method can be ...
openaire   +2 more sources

Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates

Journal of Visualized Experiments, 2023
Chromosome conformation capture (3C) is a powerful tool that has spawned a family of similar techniques (e.g., Hi-C, 4C, and 5C, referred to here as 3C techniques) that provide detailed information of the three-dimensional organization of chromatin. The 3C techniques have been used in a wide range of studies, from monitoring the changes in chromatin ...
Joniec, Acadia, Leszczynski, Joseph, Ndoye, Sokhna, Sylvia, Jillian, Weicksel, Steven   +4 more
openaire   +2 more sources