Results 171 to 180 of about 2,127,240 (398)

An Allele of Glutamate Formiminotransferase Triggers 5‐Methyl‐Tetrahydrofolate‐to‐MeFox Conversion and Facilitates Folate Biofortification in Maize

Advanced Science, EarlyView.
This work demonstrates the distinct roles of the glutamate formiminotransferase (GFT) enzyme in plants. The GFT triggers the conversion of 5‐methyl‐tetrahydrofolate to MeFox in plants, a process distinct from its role as a formiminotransferase in mammals.
Tong Lian, Wenzhu Guo, Yanjing Wang, Weiwei Wen, Weixuan Wang, Ling Jiang, Qiuju Liang, Ji'an Liu, Haijun Liu, Yuan Xue, Lixu Pan, Qiaoquan Liu, Ping Yin, Delin Zhang, Jianbing Yan, Chunyi Zhang   +15 more
wiley   +1 more source

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits

Advanced Science, EarlyView.
Genes associated with endometriosis risk are highly expressed in M2 macrophages, particularly ligands IL1A and IL1B. Endometrial‐type epithelium and stroma are likely recipients of these ligands. While IL1B treatment disturbs epithelial organization, blockage of the signaling results in a dose‐dependent decrease in spontanesous and evoked pain, reduces
Soledad Ochoa, Fernanda S. Rasquel‐Oliveira, Brett McKinnon, Marcela Haro, Sugarniya Subramaniam, Pak Yu, Simon Coetzee, Michael S. Anglesio, Kelly N. Wright, Raanan Meyer, Anne E. Porter, Caroline E. Gargett, Sally Mortlock, Grant W. Montgomery, Michael S. Rogers, Kate Lawrenson   +15 more
wiley   +1 more source

Chromosomal mapping of a middle-repetitive DNA sequence in a cluster of five species of Hawaiian Drosophila. [PDF]

, 1984
John A. Hunt, John G. Bishop, Hampton L. Carson   +2 more
openalex   +1 more source

POLE Deficiency Exacerbates Diesel Engine Exhaust‐Induced Genomic Instability and Malignant Transformation of Bronchial Epithelial Cells

Advanced Science, EarlyView.
This study establishes a diesel engine exhaust (DEE)‐induced malignant transformation model in bronchial epithelial cells. Whole genome sequencing（WGS） and RNA‐seq reveal DEE‐induced mutational signatures and gene expression profiles. Mechanistically, DEEaffect polymerase epsilon (POLE) and mismatch repair, driving genomic instability and promoting ...
Pimei Zhang, Zhaoxu Wu, Qiang Ju, Nuo Xu, Xian Chen, Hongguang Chen, Shuaishuai Yang, Jing Ji, Yanjie Zhao   +8 more
wiley   +1 more source

Patterns and Processes of Genomic Evolution Inferred From the Ten Smallest Vertebrate Genomes

Advanced Science, EarlyView.
By integrating phylogenetic relationships derived from nuclear DNA with population genetic analyses across ten pufferfish species, the genetic differentiation mechanisms underpinning the radiative speciation of the most compact vertebrate genomes has elucidated.
Kaiqiang Liu, Qian Wang, Ning Wang, Lingfeng Meng, Shuo Li, Hong‐Yan Wang, Yuyan Liu, Qian Liu, Yangqing Zhang, Lucas B. Doretto, Mengqi Zhang, Yating Qin, Shanshan Pan, Shenglei Han, Weijing Li, Shanshan Liu, Fengtao Gao, Axel Meyer, Jussi Taipale, Guangyi Fan, Manfred Schartl, Jilin Zhang, Changwei Shao   +22 more
wiley   +1 more source

Optical Genome Mapping as a New Approach to Detecting Cytogenetic Abnormalities: Why Is It Difficult in Multiple Myeloma?

Turkish Journal of Hematology
Ayşe Gül Bayrak Tokaç, Mehmet Burak Mutlu, Simge Erdem, Aynur Aday   +3 more
doaj   +1 more source

Mapping of the pattern of DNA replication in polytene chromosomes from Chironomus thummi using monoclonal anti‐bromodeoxyuridine antibodies [PDF]

, 1985
Linda Allison, Donna J. Arndt‐Jovin, Howard G. Gratzner, Thérèse Ternynck, Michel Robert‐Nicoud   +4 more
openalex   +1 more source

A Two‐Protein Chemoreceptor Complex Regulates Oxygen Thresholds in Bacterial Magneto‐Aerotaxis

Advanced Science, EarlyView.
Magnetotactic bacteria align with Earth's magnetic field, helping them migrate toward low‐oxygen environments. This study reveals how Magnetospirillum gryphiswaldense uses a specialized flavin adenine dinucleotide (FAD)‐dependent chemoreceptor, composed of two interacting proteins, for precise navigation in oxygen gradients.
Julian Herz, Carina Weigel, Leonie Scheder, Raz Zarivach, Itay Algov, Yonatan Chemla, Felix Popp, Cornelius Riese, Mohammad A. Charsooghi, Lital Alfonta, Michael M. Meijler, Dirk Schüler, Damien Faivre, Daniel Pfeiffer   +13 more
wiley   +1 more source

Isolation and mapping of a polymorphic DNA sequence (pMCT32.1) on chromosome 3 [D3S31]

, 1988
M. Carlson, Yusuke Nakamura, K. Krapcho, P. O’Connell, M. Leppert, G.M. Lathrop, J.-M. Lalouel, R. White   +7 more
openalex   +2 more sources

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source