Results 91 to 100 of about 11,267,652 (394)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Rapid interphase and metaphase assessment of specific chromosomal changes in neuroectodermal tumor cells by in situ hybridization with chemically modified DNA probes [PDF]

, 1988
Repeated DNAs from the constitutive heterochromatin of human chromosomes 1 and 18 were used as probes in nonradioactive in situ hybridization experiments to define specific numerical and structural chromosome aberrations in three human glioma cell lines ...
A.H.N. Hopman, Atkin, Bigner, Brigati, Burns, Burns, Carine, Cavenee, Comings, Cooke, Cooke, Cremer, D. Tesin, Dale, Devilee, Devilee, Dudin, Durnam, Gosden, Hadlaczky, Hall, Henn, Higgins, Hopman, Hopman, Hopman, Hopman, Hopman, Joseph, Julien, Kinzler, Kohl, L. Manuelidis, Landegent, Landegent, Langer-Safer, Leary, Lund Jorgensen, Maniatis, Manuelidis, Manuelidis, Manuelidis, Manuelidis, Manuelidis, Manuelidis, Manuelidis, Manuelidis, Manuelidis, Manuelidis, McDermid, Müller, Müncke, Pinkel, Pinkel, Rappold, Schardin, Schwab, Shapiro, Siegel, T. Cremer, Therman, Trask, Willard, Wu, Yang   +64 more
core   +1 more source

The structure, function and evolution of a complete human chromosome 8

Nature, 2020
The complete assembly of each human chromosome is essential for understanding human biology and evolution1,2. Here we use complementary long-read sequencing technologies to complete the linear assembly of human chromosome 8.
Glennis A. Logsdon, Mitchell R. Vollger, Pinghsun Hsieh, Yafei Mao, M. Liskovykh, S. Koren, S. Nurk, L. Mercuri, Philip C. Dishuck, A. Rhie, L. G. de Lima, T. Dvorkina, David Porubsky, William T. Harvey, Alla Mikheenko, Andrey V. Bzikadze, Milinn Kremitzki, Tina A. Graves-Lindsay, Chirag Jain, Kendra Hoekzema, S. Murali, Katherine M. Munson, Carl A. Baker, Melanie Sorensen, Alexandra M. Lewis, U. Surti, J. Gerton, V. Larionov, M. Ventura, K. Miga, A. Phillippy, E. Eichler   +31 more
semanticscholar   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Chromosome number and satellited chromosome morphology of eleven species of Arachis (Leguminosae)

Bonplandia, 2005
The chromosome number was determined in eleven recently-described species of Arachís belonging to five different axonomic sections.  Two new species  of section  Arachís, A. Gregoryí and A.
Andréa del Pilar De Souza Penaloza, José Fransisco Montenegro Valls   +1 more
doaj  

On a break with the X: the role of repair of double-stranded DNA breaks in X-linked disease [PDF]

, 2012
The problem of managing free reactive DNA ends in eukaryotic cells has resulted in the development of a number of mechanisms in order to ensure that free ends are rendered non-reactive, or that the double-strand DNA breaks generating the free ends are ...
Cecceroni, Lucia, De Caris, Laura, Tummala, Hemanth   +2 more
core   +4 more sources

Comparative genomics reveals the dynamics of chromosome evolution in Lepidoptera

Nature Ecology & Evolution
Chromosomes are a central unit of genome organization. One-tenth of all described species on Earth are butterflies and moths, the Lepidoptera, which generally possess 31 chromosomes.
Charlotte J. Wright, Lewis Stevens, Alexander Mackintosh, M. Lawniczak, Mark Blaxter   +4 more
semanticscholar   +1 more source

Role of the Number of Microtubules in Chromosome Segregation during Cell Division [PDF]

PLoS ONE, 2015
Faithful segregation of genetic material during cell division requires alignment of chromosomes between two spindle poles and attachment of their kinetochores to each of the poles.
Z. Bertalan, Z. Budrikis, C. L. La Porta, S. Zapperi   +3 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation

, 2020
X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Barr M. L., Comings D. E., Delbrück M., Rastan S., Rosspopoff O.   +4 more
core   +1 more source