Results 11 to 20 of about 405,684 (326)
Chromosome Architecture and Genome Organization. [PDF]
PLoS ONE, 2015 How the same DNA sequences can function in the three-dimensional architecture of interphase nucleus, fold in the very compact structure of metaphase chromosomes and go precisely back to the original interphase architecture in the following cell cycle ...
Giorgio Bernardi
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Bacterial Chromosome Organization and Segregation [PDF]
Annual Review of Cell and Developmental Biology, 2018 If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long, approximately 1,000 times the length of a cell. Not only must cells massively compact their genetic material, but they must also organize their DNA in a manner that is ...
Badrinarayanan, Anjana +2 more
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Scientific Reports, 2021 Mammalian artificial chromosomes derived from native chromosomes have been applied to biomedical research and development by generating cell sources and transchromosomic (Tc) animals.
Satoshi Abe +13 more
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Bacterial chromosome segregation by the ParABS system [PDF]
Open Biology, 2020 Proper chromosome segregation during cell division is essential in all domains of life. In the majority of bacterial species, faithful chromosome segregation is mediated by the tripartite ParABS system, consisting of an ATPase protein ParA, a CTPase and ...
Adam S. B. Jalal, Tung B. K. Le
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Nature Communications, 2023 DNA replication stress can generate under-replicated DNA regions which is fixed by an atypical form of DNA repair synthesis in mitosis (MiDAS). Here the authors show that translesion and replicative DNA polymerases cooperate via the POLD3 subunit to ...
Wei Wu +7 more
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Constructing Auxin-Inducible Degron Mutants Using an All-in-One Vector
Pharmaceuticals, 2020 Conditional degron-based methods are powerful for studying protein function because a degron-fused protein can be rapidly and efficiently depleted by adding a defined ligand.
Aisha Yesbolatova +2 more
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Chromosome Organization: Original Condensins [PDF]
Current Biology, 2014 Two new studies reveal the main actors involved in the resolution and segregation of newly replicated origins in bacteria. These results have important implications for our understanding of the mechanisms involved in precisely coordinating chromosome organization, segregation and replication.
Diego I. Cattoni +2 more
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MukBEF, a Chromosomal Organizer [PDF]
Microbial Physiology, 2014 Global folding of bacterial chromosome requires the activity of condensins. These highly conserved proteins are involved in various aspects of higher-order chromatin dynamics in a diverse range of organisms. Two distinct superfamilies of condensins have been identified in bacteria.
Valentin V, Rybenkov +3 more
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Spatial organization of bacterial chromosomes [PDF]
Current Opinion in Microbiology, 2014 Bacterial chromosomes are organized in stereotypical patterns that are faithfully and robustly regenerated in daughter cells. Two distinct spatial patterns were described almost a decade ago in our most tractable model organisms. In recent years, analysis of chromosome organization in a larger and more diverse set of bacteria and a deeper ...
Xindan Wang, David Z. Rudner
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Cell Reports, 2016 Smc/ScpAB promotes chromosome segregation in prokaryotes, presumably by compacting and resolving nascent sister chromosomes. The underlying mechanisms, however, are poorly understood.
Anita Minnen +5 more
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