Results 11 to 20 of about 4,074,715 (354)
Bacterial Chromosome Organization and Segregation [PDF]
Annual Review of Cell and Developmental Biology, 2018 If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long, approximately 1,000 times the length of a cell. Not only must cells massively compact their genetic material, but they must also organize their DNA in a manner that is ...
Badrinarayanan, Anjana +2 more
core +8 more sources
Chromosome Architecture and Genome Organization. [PDF]
PLoS ONE, 2015 How the same DNA sequences can function in the three-dimensional architecture of interphase nucleus, fold in the very compact structure of metaphase chromosomes and go precisely back to the original interphase architecture in the following cell cycle ...
Giorgio Bernardi
doaj +5 more sources
Effects of human sex chromosome dosage on spatial chromosome organization. [PDF]
Mol Biol Cell, 2018 Sex chromosome aneuploidies (SCAs) are common genetic syndromes characterized by the presence of an aberrant number of X and Y chromosomes due to meiotic defects. These conditions impact structure and function of diverse tissues, but the proximal effects
Jowhar Z +9 more
europepmc +2 more sources
The biology and polymer physics underlying large-scale chromosome organization. [PDF]
Traffic, 2018 Chromosome large‐scale organization is a beautiful example of the interplay between physics and biology. DNA molecules are polymers and thus belong to the class of molecules for which physicists have developed models and formulated testable hypotheses to
Sazer S, Schiessel H.
europepmc +2 more sources
Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization. [PDF]
Nat Struct Mol Biol, 2018 Two variant cohesin complexes containing SMC1, SMC3, RAD21 and either SA1 (also known as STAG1) or SA2 (also known as STAG2) are present in all cell types.
Kojic A +8 more
europepmc +2 more sources
Organization of the Mitotic Chromosome [PDF]
Science, 2017 Mitotic chromosomes are among the most recognizable structures in the cell, yet for over a century their internal organization remains largely unsolved.
Dekker, Job +6 more
core +7 more sources
The 10-nm chromatin fiber and its relationship to interphase chromosome organization. [PDF]
Biochem Soc Trans, 2018 A chromosome is a single long DNA molecule assembled along its length with nucleosomes and proteins. During interphase, a mammalian chromosome exists as a highly organized supramolecular globule in the nucleus.
Hansen JC +9 more
europepmc +2 more sources
Chromosome intermingling-the physical basis of chromosome organization in differentiated cells. [PDF]
Nucleic Acids Res, 2016 Chromosome territories (CTs) in higher eukaryotes occupy tissue-specific non-random three-dimensional positions in the interphase nucleus. To understand the mechanisms underlying CT organization, we mapped CT position and transcriptional changes in ...
Maharana S +5 more
europepmc +2 more sources
Chromosome Organization and Replisome Dynamics in
mBio, 2015 Subcellular organization of the bacterial nucleoid and spatiotemporal dynamics of DNA replication and segregation have been studied intensively, but the functional link between these processes remains poorly understood.
Isabella Santi, John D. McKinney
doaj +2 more sources