Results 1 to 10 of about 210,847 (212)

A low Smc flux avoids collisions and facilitates chromosome organization in Bacillus subtilis [PDF]

eLife, 2021
SMC complexes are widely conserved ATP-powered DNA-loop-extrusion motors indispensable for organizing and faithfully segregating chromosomes. How SMC complexes translocate along DNA for loop extrusion and what happens when two complexes meet on the same ...
Anna Anchimiuk, Virginia S Lioy, Florian Patrick Bock, Anita Minnen, Frederic Boccard, Stephan Gruber   +5 more
doaj   +2 more sources

Chromosome Organization in Early Meiotic Prophase [PDF]

Frontiers in Cell and Developmental Biology, 2021
One of the most fascinating aspects of meiosis is the extensive reorganization of the genome at the prophase of the first meiotic division (prophase I). The first steps of this reorganization are observed with the establishment of an axis structure, that
Corinne Grey, Bernard de Massy
doaj   +2 more sources

Chromosome organization by one-sided and two-sided loop extrusion [PDF]

eLife, 2020
SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and progressively growing DNA loops.
Edward J Banigan, Aafke A van den Berg, Hugo B Brandão, John F Marko, Leonid A Mirny   +4 more
doaj   +2 more sources

Coupling chromosome organization to genome segregation in Archaea [PDF]

Nature Communications
Chromosome segregation is a fundamental process in all life forms and requires coordination with genome organization, replication and cell division. The mechanism that mediates chromosome segregation in archaea remains enigmatic.
Azhar F. Kabli, Irene W. Ng, Nicholas Read, Parul Pal, Julia Reimann, Ngat T. Tran, Sonja-Verena Albers, Tung B. K. Le, Daniela Barillà   +8 more
doaj   +3 more sources

A Role for the Mre11-Rad50-Xrs2 Complex in Gene Expression and Chromosome Organization [PDF]

Molecular Cell, 2021
Julie Soutourina, Philippe Pasero, Krzysztof Ginalski   +2 more
exaly   +2 more sources

MCMBP promotes the assembly of the MCM2–7 hetero-hexamer to ensure robust DNA replication in human cells

eLife, 2022
The MCM2–7 hetero-hexamer is the replicative DNA helicase that plays a central role in eukaryotic DNA replication. In proliferating cells, the expression level of the MCM2–7 hexamer is kept high, which safeguards the integrity of the genome. However, how
Yuichiro Saito, Venny Santosa, Kei-ichiro Ishiguro, Masato T Kanemaki   +3 more
doaj   +1 more source

Braiding topology and the energy landscape of chromosome organization proteins [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2020
Aram Davtyan, Peter Wolynes, Nicholas P Schafer   +2 more
exaly   +2 more sources

Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage

Nature Communications, 2022
During meiosis, the number and distribution of crossovers (COs) are tightly controlled, but the mechanistic basis of this control is unclear. Here, by combining experimental data and mathematical modeling, the study advocates a CO patterning model via ...
Stéphanie Durand, Qichao Lian, Juli Jing, Marcel Ernst, Mathilde Grelon, David Zwicker, Raphael Mercier   +6 more
doaj   +1 more source

Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice

Scientific Reports, 2021
Mammalian artificial chromosomes derived from native chromosomes have been applied to biomedical research and development by generating cell sources and transchromosomic (Tc) animals.
Satoshi Abe, Kazuhisa Honma, Akane Okada, Kanako Kazuki, Hiroshi Tanaka, Takeshi Endo, Kayoko Morimoto, Takashi Moriwaki, Shusei Hamamichi, Yuji Nakayama, Teruhiko Suzuki, Shoko Takehara, Mitsuo Oshimura, Yasuhiro Kazuki   +13 more
doaj   +1 more source

Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells

Nature Communications, 2023
DNA replication stress can generate under-replicated DNA regions which is fixed by an atypical form of DNA repair synthesis in mitosis (MiDAS). Here the authors show that translesion and replicative DNA polymerases cooperate via the POLD3 subunit to ...
Wei Wu, Szymon A. Barwacz, Rahul Bhowmick, Katrine Lundgaard, Marisa M. Gonçalves Dinis, Malgorzata Clausen, Masato T. Kanemaki, Ying Liu   +7 more
doaj   +1 more source