Results 1 to 10 of about 6,725 (195)

Condensin I but not Condensin II is crucial for mitotic chromosome mechanics [PDF]

Nature Communications
During mitotic cell division, pliable interphase chromatin is transformed into stiff mitotic chromosomes able to withstand the pushing and pulling forces of the mitotic spindle.
Christian F. Nielsen, Hannes Witt, Andrea Ridolfi, Bas Kempers, Emma M. J. Chameau, Stijn van der Smagt, Justine Sitz, Marin Barisic, Erwin J. G. Peterman, Gijs J. L. Wuite, Ian D. Hickson   +10 more
doaj   +5 more sources

Differential Contributions of Condensin I and Condensin II to Mitotic Chromosome Architecture in Vertebrate Cells [PDF]

Cell, 2003
The canonical condensin complex (henceforth condensin I) plays an essential role in mitotic chromosome assembly and segregation from yeast to humans. We report here the identification of a second condensin complex (condensin II) from vertebrate cells.
Ana Losada, Andrew Neuwald, Takao Ono
exaly   +6 more sources

Condensin II activation by M18BP1 [PDF]

Molecular Cell
ABSTRACT Condensin complexes promote the drastic spatial rearrangement of the genome upon mitotic entry. Condensin II initiates chromosome condensation in early mitosis. To prevent chromosome condensation during interphase, condensin II is inhibited by MCPH1, but the mechanism is unknown.
Erin E Cutts
exaly   +6 more sources

Functional dissection of the Drosophila melanogaster condensin subunit Cap-G reveals its exclusive association with condensin I. [PDF]

PLoS Genetics, 2013
The heteropentameric condensin complexes have been shown to participate in mitotic chromosome condensation and to be required for unperturbed chromatid segregation in nuclear divisions.
Sabine Herzog, Sonal Nagarkar Jaiswal, Evelin Urban, Anna Riemer, Sina Fischer, Stefan K Heidmann   +5 more
doaj   +3 more sources

Molecular mechanism of condensin I activation by KIF4A

EMBO Journal
During mitosis, the condensin I and II complexes compact chromatin into chromosomes. Loss of the chromokinesin, KIF4A, results in reduced condensin I association with chromosomes, but the molecular mechanism behind this phenotype is unknown.
Eugene Kim, Luis Aragon, Erin E Cutts
exaly   +2 more sources

Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit

eLife, 2022
Condensin I is a pentameric protein complex that plays an essential role in mitotic chromosome assembly in eukaryotic cells. Although it has been shown that condensin I loading is mitosis specific, it remains poorly understood how the robust cell cycle ...
Shoji Tane, Keishi Shintomi, Kazuhisa Kinoshita, Yuko Tsubota, Makoto M Yoshida, Tomoko Nishiyama, Tatsuya Hirano   +6 more
doaj   +1 more source

An SMC-like protein binds and regulates Caenorhabditis elegans condensins. [PDF]

PLoS Genetics, 2017
Structural Maintenance of Chromosomes (SMC) family proteins participate in multisubunit complexes that govern chromosome structure and dynamics.
Lucy Fang-I Chao, Meha Singh, James Thompson, John R Yates, Kirsten A Hagstrom   +4 more
doaj   +1 more source

Condensins under the microscope [PDF]

Journal of Cell Biology, 2018
Condensins are key players in mitotic chromosome condensation. Using an elegant combination of state-of-the-art imaging techniques, Walther et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201801048) counted the number of Condensins, examined their behaviors on human mitotic chromosomes, and integrated the quantitative data to propose a new ...
Kazuhiro Maeshima, Kayo Hibino, Damien F. Hudson   +2 more
openaire   +3 more sources

Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1. [PDF]

PLoS ONE, 2011
Condensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with PARP1 in response to DNA damage and plays a role in single-strand break repair.
Xiangduo Kong, Jared Stephens, Alexander R Ball, Jason T Heale, Daniel A Newkirk, Michael W Berns, Kyoko Yokomori   +6 more
doaj   +1 more source

Molecular dissection of condensin II-mediated chromosome assembly using in vitro assays

eLife, 2022
In vertebrates, condensin I and condensin II cooperate to assemble rod-shaped chromosomes during mitosis. Although the mechanism of action and regulation of condensin I have been studied extensively, our corresponding knowledge of condensin II remains ...
Makoto M Yoshida, Kazuhisa Kinoshita, Yuuki Aizawa, Shoji Tane, Daisuke Yamashita, Keishi Shintomi, Tatsuya Hirano   +6 more
doaj   +1 more source