A role for condensin-mediator interaction in mitotic chromosome organization [PDF]
Nature CommunicationsCondensin organizes eukaryotic genomes into three-dimensional (3D) chromosome architectures that support accurate chromosome segregation during mitosis. However, the molecular mechanisms underlying this organization remain unclear.
Osamu Iwasaki +13 more
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Condensin I but not Condensin II is crucial for mitotic chromosome mechanics [PDF]
Nature CommunicationsDuring mitotic cell division, pliable interphase chromatin is transformed into stiff mitotic chromosomes able to withstand the pushing and pulling forces of the mitotic spindle.
Christian F. Nielsen +10 more
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Cell-Cycle Regulation of Dynamic Chromosome Association of the Condensin Complex
Cell Reports, 2018 Summary: Eukaryotic cells inherit their genomes in the form of chromosomes, which are formed from the compaction of interphase chromatin by the condensin complex. Condensin is a member of the structural maintenance of chromosomes (SMC) family of ATPases,
Sofía Muñoz, Frank Uhlmann
exaly +3 more sources
Condensin complexes: from chromatin organization to disease [PDF]
NucleusCondensin complexes are indispensable for mitotic chromosome condensation. In this review, we summarize their structural and functional features, focusing on ATP-dependent loop extrusion and mitotic chromatin folding. We discuss current models of mitotic
Lirong Shu, Haoyue Zhang
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Molecular Mechanism of Condensin I Activation by KIF4A
EMBO JournalDuring mitosis, the condensin I and II complexes compact chromatin into chromosomes. Loss of the chromokinesin, KIF4A, results in reduced condensin I association with chromosomes, but the molecular mechanism behind this phenotype is unknown.
Eugene Kim, Luis Aragon, Erin E Cutts
exaly +2 more sources
Decoding Mitotic Chromosome Assembly: Three Rules Governing Condensin–Cohesin Engagement [PDF]
ResearchMitotic chromosome formation depends on coordinated SMC complex activities, yet how condensin engages cohesin during this process remains unclear. Samejima et al.
Haiyan Yan, Xinyu Zhou, Fangwei Wang
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A phospho-switch to trigger mitotic chromosome condensation [PDF]
Biology DirectOne of the most eye-catching events in cell biology is the condensation of chromosomes. During mitosis, the diffuse interphase chromatin rearranges into compact, rod-shaped chromosomes that can be precisely segregated between the daughter cells.
Alessandro Borsellini
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Functional interplay between condensin I and topoisomerase IIα in single-molecule DNA compaction [PDF]
Nature CommunicationsCondensin I and topoisomerase IIα (topo IIα) are chromosomal ATPases essential for mitotic chromosome assembly. Mechanistically how the two ATPases cooperate to assemble mitotic chromosomes remains unknown.
Yuko Tsubota +7 more
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Condensin loop extrusion properties, roadblocks, and role in homology search during recombination in S. cerevisiae [PDF]
The EMBO JournalThe in vivo mechanism, cis-acting roadblocks, and biological functions of DNA loop extrusion by eukaryotic SMC complexes remain incompletely defined. Here, we identify condensin-dependent Hi-C contact stripes at the recombination enhancer (RE) and at ...
Vinciane Piveteau +6 more
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eLife, 2022 Condensin I is a pentameric protein complex that plays an essential role in mitotic chromosome assembly in eukaryotic cells. Although it has been shown that condensin I loading is mitosis specific, it remains poorly understood how the robust cell cycle ...
Shoji Tane +6 more
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