A role for condensin-mediator interaction in mitotic chromosome organization [PDF]
Nature CommunicationsCondensin organizes eukaryotic genomes into three-dimensional (3D) chromosome architectures that support accurate chromosome segregation during mitosis. However, the molecular mechanisms underlying this organization remain unclear.
Osamu Iwasaki +13 more
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Decoding Mitotic Chromosome Assembly: Three Rules Governing Condensin–Cohesin Engagement [PDF]
ResearchMitotic chromosome formation depends on coordinated SMC complex activities, yet how condensin engages cohesin during this process remains unclear. Samejima et al.
Haiyan Yan, Xinyu Zhou, Fangwei Wang
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Condensin complexes: from chromatin organization to disease [PDF]
NucleusCondensin complexes are indispensable for mitotic chromosome condensation. In this review, we summarize their structural and functional features, focusing on ATP-dependent loop extrusion and mitotic chromatin folding. We discuss current models of mitotic
Lirong Shu, Haoyue Zhang
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A phospho-switch to trigger mitotic chromosome condensation [PDF]
Biology DirectOne of the most eye-catching events in cell biology is the condensation of chromosomes. During mitosis, the diffuse interphase chromatin rearranges into compact, rod-shaped chromosomes that can be precisely segregated between the daughter cells.
Alessandro Borsellini
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Functional interplay between condensin I and topoisomerase IIα in single-molecule DNA compaction [PDF]
Nature CommunicationsCondensin I and topoisomerase IIα (topo IIα) are chromosomal ATPases essential for mitotic chromosome assembly. Mechanistically how the two ATPases cooperate to assemble mitotic chromosomes remains unknown.
Yuko Tsubota +7 more
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Molecular mechanism of condensin I activation by KIF4A
EMBO JournalDuring mitosis, the condensin I and II complexes compact chromatin into chromosomes. Loss of the chromokinesin, KIF4A, results in reduced condensin I association with chromosomes, but the molecular mechanism behind this phenotype is unknown.
Erin E Cutts, Eugene Kim, Luis Aragon
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Condensin loop extrusion properties, roadblocks, and role in homology search during recombination in S. cerevisiae [PDF]
The EMBO JournalThe in vivo mechanism, cis-acting roadblocks, and biological functions of DNA loop extrusion by eukaryotic SMC complexes remain incompletely defined. Here, we identify condensin-dependent Hi-C contact stripes at the recombination enhancer (RE) and at ...
Vinciane Piveteau +6 more
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The length and strength of compartmental interactions are modulated by condensin II activity. [PDF]
PLoS GeneticsThe spatial organization of the genome is crucial for its function and integrity. Although the ring-like SMC complex condensin II has a well-documented role in organizing mitotic chromosomes, its function in interphase chromatin structure has remained ...
Randi Isenhart +7 more
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Condensin II interacts with BLM helicase in S phase to maintain genome stability [PDF]
Communications BiologyVertebrates possess two condensins, I and II, that are essential for chromosome condensation and segregation. Condensin II has also been implicated in maintaining genome integrity outside of mitosis, though the underlying mechanisms are unclear. Here, we
Brian Rodemoyer +3 more
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Cohesin and condensin regulate chromosome topology and play an essential role in maintaining pluripotency in embryonic stem cells [PDF]
Scientific ReportsCohesin and condensin, two related protein complexes, play essential roles in ensuring the accurate segregation of the genome into daughter cells during cell division. However, the interaction between cohesin and condensin in embryonic stem cells remains
Eui-Hwan Choi, Keun P. Kim
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