Results 31 to 40 of about 6,249 (200)

Condensin in Chromatid Cohesion and Segregation [PDF]

Cytogenetic and Genome Research, 2015
After replication of genomic DNA during the S phase, 2 chromatids hold together longitudinally. When cells enter mitosis, the paired sister chromatids start to condense and then segregate into individual chromatids except for the centromeric region. Upon attachment of microtubules to the kinetochore, subsequent pulling of the 2 sister chromatids by the
Susumu, Uchiyama, Kiichi, Fukui
openaire   +2 more sources

Chromosome Organization: Original Condensins [PDF]

Current Biology, 2014
Two new studies reveal the main actors involved in the resolution and segregation of newly replicated origins in bacteria. These results have important implications for our understanding of the mechanisms involved in precisely coordinating chromosome organization, segregation and replication.
Diego I. Cattoni, Antoine Le Gall, Marcelo Nöllmann   +2 more
openaire   +2 more sources

The expanding territories of condensin II [PDF]

Cell Cycle, 2015
The 3D structure of the eukaryotic genome and its spatial regulation within nuclei are governed by a range of architectural proteins. One class of such factors is the condensins, highly conserved multi-subunit protein complexes. Most eukaryotic species have 2 condensins, condensin I and II, and both condensins are essential for mitotic chromosome ...
Yoko Ito, Masashi Narita
openaire   +3 more sources

Condensin-driven loop extrusion on supercoiled DNA

, 2022
Condensin, a structural maintenance of chromosomes (SMC) complex, has been shown to be a molecular motor protein that organizes chromosomes by extruding loops of DNA.
Pradhan, B., van der Torre, J., Dekker, C., Martin Gonzalez, A. (author), Kim, E. (author), van der Torre, J. (author), Kim, E., Pradhan, B. (author), Martin Gonzalez, A., Dekker, C. (author)   +9 more
core   +2 more sources

Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III.

PLoS Genetics, 2023
Despite recent advances in single-molecule and structural analysis of condensin activity in vitro, mechanisms of functional condensin loading and loop extrusion that lead to specific chromosomal organization remain unclear.
Manikarna Dinda, Ryan D Fine, Shekhar Saha, Zhenjia Wang, Chongzhi Zang, Mingguang Li, Jeffrey S Smith   +6 more
doaj   +1 more source

Small Molecule Condensin Inhibitors [PDF]

ACS Infectious Diseases, 2018
Condensins play a unique role in orchestrating the global folding of the chromosome, an essential cellular process, and contribute to human disease and bacterial pathogenicity. As such, they represent an attractive and as yet untapped target for diverse therapeutic interventions.
Hang Zhao, Zoya M. Petrushenko, John K. Walker, Jerome Baudry, Helen I. Zgurskaya, Valentin V. Rybenkov   +5 more
openaire   +2 more sources

Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα [PDF]

, 2012
© 2012 Samejima et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication dateMitotic chromosome formation involves a relatively minor ...
Cooke, C.A., Lydia C. Green, Itaru Samejima, Flavia de Lima Alves, Farr, CJ, Samejima, I., Earnshaw, W.C., Samejima, K., Vagnarelli, P., Kelly, D.A., Kerr, A., David A. Kelly, Hudson, DF, Hudson, D.F., Carol A. Cooke, Kerr, A, Vargiu, G., Cooke, CA, Giulia Vargiu, Hiromi Ogawa, Green, LC, Alves, FDL, Damien F. Hudson, Ogawa, H, de Lima Alves, F, Ogawa, H., Alves, F.L., Green, L.C., Vagnarelli, P, Kumiko Samejima, Ohta, S, Alastair Kerr, Christine J. Farr, Shinya Ohta, William C. Earnshaw, Vargiu, G, Ohta, S., Farr, C.J., Paola Vagnarelli, Juri Rappsilber, Rappsilber, J., Samejima, I, Kelly, DA, Rappsilber, J, Samejima, K, Earnshaw, WC   +45 more
core   +1 more source

Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission

Cell Reports, 2020
Summary: Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear.
Rajan Pandey, Steven Abel, Matthew Boucher, Richard J. Wall, Mohammad Zeeshan, Edward Rea, Aline Freville, Xueqing Maggie Lu, Declan Brady, Emilie Daniel, Rebecca R. Stanway, Sally Wheatley, Gayani Batugedara, Thomas Hollin, Andrew R. Bottrill, Dinesh Gupta, Anthony A. Holder, Karine G. Le Roch, Rita Tewari   +18 more
doaj   +1 more source

Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase

eLife, 2023
The localization of condensin along chromosomes is crucial for their accurate segregation in anaphase. Condensin is enriched at telomeres but how and for what purpose had remained elusive.
Léonard Colin, Celine Reyes, Julien Berthezene, Laetitia Maestroni, Laurent Modolo, Esther Toselli, Nicolas Chanard, Stephane Schaak, Olivier Cuvier, Yannick Gachet, Stephane Coulon, Pascal Bernard, Sylvie Tournier   +12 more
doaj   +1 more source

Condensin-Condensin Interactions Facilitate Mitotic Chromosome Assembly in Xenopus Egg Extracts. [PDF]

Genes Cells
ABSTRACT Condensins are large protein complexes that play a central role in mitotic chromosome assembly in eukaryotes. Our previous mutational analyses of condensin I, combined with Xenopus egg cell‐free extracts, provided evidence that dynamic condensin‐condensin ...
Kinoshita K, Aizawa Y, Hirano T.
europepmc   +4 more sources