Results 31 to 40 of about 7,152 (199)
Small Molecule Condensin Inhibitors [PDF]
ACS Infectious Diseases, 2018 Condensins play a unique role in orchestrating the global folding of the chromosome, an essential cellular process, and contribute to human disease and bacterial pathogenicity. As such, they represent an attractive and as yet untapped target for diverse therapeutic interventions.
Hang Zhao +5 more
openaire +2 more sources
Interdependency and phosphorylation of KIF4 and condensin I are essential for organization of chromosome scaffold. [PDF]
PLoS ONE, 2017 Kinesin family member 4 (KIF4) and condensins I and II are essential chromosomal proteins for chromosome organization by locating primarily to the chromosome scaffold.
Rawin Poonperm +3 more
doaj +1 more source
Molecular basis for SMC rod formation and its dissolution upon DNA binding. [PDF]
, 2015 SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a constitutive "hinge" dimerization domain with an ATP-regulated "head ...
Soh, Young-Min +69 more
core +1 more source
Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C.elegans Embryos [PDF]
, 2015 During cell division, chromatin alternates between a condensed state to facilitate chromosome segregation and a decondensed form when DNA replicates.
Blow, J. Julian; id_orcid +11 more
core +1 more source
Cell Reports, 2015 Condensin is a conserved chromosomal complex necessary to promote mitotic chromosome condensation and sister chromatid resolution during anaphase. Here, we report that yeast condensin binds to replicated centromere regions.
Joanne Leonard +6 more
doaj +1 more source
A new family of bacterial condensins [PDF]
Molecular Microbiology, 2011 SummaryCondensins play a central role in global chromatin organization. In bacteria, two families of condensins have been identified, the MukBEF and SMC–ScpAB complexes. Only one of the two complexes is usually found in a given species, giving rise to a paradigm that a single condensin organizes bacterial chromosomes.
Zoya M, Petrushenko +2 more
openaire +2 more sources
Condensin I reveals new insights on mouse meiotic chromosome structure and dynamics. [PDF]
PLoS ONE, 2007 Chromosome shaping and individualization are necessary requisites to warrant the correct segregation of genomes in either mitotic or meiotic cell divisions. These processes are mainly prompted in vertebrates by three multiprotein complexes termed cohesin
Alberto Viera +6 more
doaj +1 more source
Cell Reports, 2020 Summary: Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear.
Rajan Pandey +18 more
doaj +1 more source
Nucleic Acids Research, 2022 Abstract Condensin I and condensin II are multi-subunit complexes that are known for their individual roles in genome organization and preventing genomic instability. However, interactions between condensin I and condensin II subunits and cooperative roles for condensin I and condensin II, outside of their genome organizing functions ...
Jacqueline R Ward +7 more
openaire +2 more sources
Mechanical Caging of Nucleic Acids Enabled by Light‐Activated Synthetic Molecular Motors
Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.A synthetic light‐driven molecular motor imposes mechanical constraints on nucleic acids, enabling “mechanical caging” as a new mode to regulate DNA structure and function through mechanical input rather than chemical masking. ABSTRACT Control over nucleic acid activity is central to biotechnology and therapeutic development.
Yuchen Ma +10 more
wiley +2 more sources