Results 51 to 60 of about 6,725 (195)
MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface
eLife, 2021 Dramatic change in chromosomal DNA morphology between interphase and mitosis is a defining features of the eukaryotic cell cycle. Two types of enzymes, namely cohesin and condensin confer the topology of chromosomal DNA by extruding DNA loops.
Martin Houlard +9 more
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Condensin DC loads and spreads from recruitment sites to create loop-anchored TADs in C. elegans
eLife, 2022 Condensins are molecular motors that compact DNA via linear translocation. In Caenorhabditis elegans, the X-chromosome harbors a specialized condensin that participates in dosage compensation (DC).
Jun Kim +9 more
doaj +1 more source
Taking cohesin and condensin in context
PLOS Genetics, 2018 Structural maintenance of chromosome (SMC) protein complexes, including cohesin and condensin, are increasingly being recognized for their important role in cancer and development, making it critical that we understand how these evolutionarily conserved multi-subunit protein complexes associate with and organize the genome.
Kobe C. Yuen, Jennifer L. Gerton
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Condensin I folds the Caenorhabditis elegans genome. [PDF]
The structural maintenance of chromosome (SMC) complexes-cohesin and condensins-are crucial for chromosome separation and compaction during cell division. During the interphase, mammalian cohesins additionally fold the genome into loops and domains. Here
Haemmerli, Anja +15 more
core +2 more sources
Condensin goes with the family but not with the flow [PDF]
Genome Biology, 2008 Condensin and cohesin are loaded onto yeast chromosomes by a common mechanism at RNA polymerase III transcribed genes. Whereas cohesin translocates from these loading sites to mediate cohesion at secondary locations, condensin remains, bringing distant sites together into clusters.
Gartenberg, MR, Merkenschlager, M
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Condensin ATPase motifs contribute differentially to the maintenance of chromosome morphology and genome stability. [PDF]
PLoS Biology, 2018 Effective transfer of genetic information during cell division requires a major reorganization of chromosome structure. This process is triggered by condensin, a conserved pentameric ATPase essential for chromosome condensation.
Roger Palou +5 more
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Chromosome Shaping by Two Condensins [PDF]
Cell Cycle, 2004 It remains a big challenge in modern cell biology to determine the mechanism by which a discrete set of rod-shaped chromosomes is assembled from an amorphous mass of interphase chromatin. Recent studies start to shed new lights on how this process is actively supported by a class of multiprotein complexes called condensins.
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RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes. [PDF]
PLoS Genetics, 2014 Condensin-mediated chromosome condensation is essential for genome stability upon cell division. Genetic studies have indicated that the association of condensin with chromatin is intimately linked to gene transcription, but what transcription-associated
Pénélope Legros +4 more
doaj +1 more source
Real-time detection of single-molecule DNA compaction by condensin I [PDF]
, 2004 BACKGROUND: Condensin is thought to contribute to large-scale DNA compaction during mitotic chromosome assembly. It remains unknown, however, how the complex reconfigures DNA structure at a mechanistic level.
Terence R Strick +8 more
core +1 more source
Condensins: Organizing and Segregating the Genome [PDF]
Current Biology, 2005 Condensins are multi-subunit protein complexes that play a central role in mitotic chromosome assembly and segregation. The complexes contain 'structural maintenance of chromosomes' (SMC) ATPase subunits, and induce DNA supercoiling and looping in an ATP-hydrolysis-dependent manner in vitro.
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