Results 41 to 50 of about 6,725 (195)
Condensin I reveals new insights on mouse meiotic chromosome structure and dynamics. [PDF]
PLoS ONE, 2007 Chromosome shaping and individualization are necessary requisites to warrant the correct segregation of genomes in either mitotic or meiotic cell divisions. These processes are mainly prompted in vertebrates by three multiprotein complexes termed cohesin
Alberto Viera +6 more
doaj +1 more source
Small Molecule Condensin Inhibitors [PDF]
ACS Infectious Diseases, 2018 Condensins play a unique role in orchestrating the global folding of the chromosome, an essential cellular process, and contribute to human disease and bacterial pathogenicity. As such, they represent an attractive and as yet untapped target for diverse therapeutic interventions.
Hang Zhao +5 more
openaire +2 more sources
The Adenomatous Polyposis Coli protein contributes to normal compaction of mitotic chromatin [PDF]
, 2012 The tumour suppressor <i>Adenomatous Polyposis Coli</i> (APC) is required for proper mitosis; however, the exact role of APC in mitosis is not understood.
Newton, Ian P. +44 more
core +1 more source
Interdependency and phosphorylation of KIF4 and condensin I are essential for organization of chromosome scaffold. [PDF]
PLoS ONE, 2017 Kinesin family member 4 (KIF4) and condensins I and II are essential chromosomal proteins for chromosome organization by locating primarily to the chromosome scaffold.
Rawin Poonperm +3 more
doaj +1 more source
Cell-Cycle Regulation of Dynamic Chromosome Association of the Condensin Complex
Cell Reports, 2018 Summary: Eukaryotic cells inherit their genomes in the form of chromosomes, which are formed from the compaction of interphase chromatin by the condensin complex. Condensin is a member of the structural maintenance of chromosomes (SMC) family of ATPases,
Rahul Thadani +4 more
doaj +1 more source
Cell Reports, 2015 Condensin is a conserved chromosomal complex necessary to promote mitotic chromosome condensation and sister chromatid resolution during anaphase. Here, we report that yeast condensin binds to replicated centromere regions.
Joanne Leonard +6 more
doaj +1 more source
A new family of bacterial condensins [PDF]
Molecular Microbiology, 2011 SummaryCondensins play a central role in global chromatin organization. In bacteria, two families of condensins have been identified, the MukBEF and SMC–ScpAB complexes. Only one of the two complexes is usually found in a given species, giving rise to a paradigm that a single condensin organizes bacterial chromosomes.
Zoya M, Petrushenko +2 more
openaire +2 more sources
Mechanical Caging of Nucleic Acids Enabled by Light‐Activated Synthetic Molecular Motors
Angewandte Chemie, EarlyView.A synthetic light‐driven molecular motor imposes mechanical constraints on nucleic acids, enabling “mechanical caging” as a new mode to regulate DNA structure and function through mechanical input rather than chemical masking. ABSTRACT Control over nucleic acid activity is central to biotechnology and therapeutic development.
Yuchen Ma +10 more
wiley +2 more sources
Nucleic Acids Research, 2022 Abstract Condensin I and condensin II are multi-subunit complexes that are known for their individual roles in genome organization and preventing genomic instability. However, interactions between condensin I and condensin II subunits and cooperative roles for condensin I and condensin II, outside of their genome organizing functions ...
Jacqueline R Ward +7 more
openaire +2 more sources
Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast.
PLoS Genetics, 2020 Correct bioriented attachment of sister chromatids to the mitotic spindle is essential for chromosome segregation. In budding yeast, the conserved protein shugoshin (Sgo1) contributes to biorientation by recruiting the protein phosphatase PP2A-Rts1 and ...
Galal Yahya +7 more
doaj +1 more source