Results 41 to 50 of about 4,930 (171)

Condensin DC loads and spreads from recruitment sites to create loop-anchored TADs in C. elegans

eLife, 2022
Condensins are molecular motors that compact DNA via linear translocation. In Caenorhabditis elegans, the X-chromosome harbors a specialized condensin that participates in dosage compensation (DC).
Jun Kim, David S Jimenez, Bhavana Ragipani, Bo Zhang, Lena A Street, Maxwell Kramer, Sarah E Albritton, Lara H Winterkorn, Ana K Morao, Sevinc Ercan   +9 more
doaj   +1 more source

Condensin ATPase motifs contribute differentially to the maintenance of chromosome morphology and genome stability. [PDF]

PLoS Biology, 2018
Effective transfer of genetic information during cell division requires a major reorganization of chromosome structure. This process is triggered by condensin, a conserved pentameric ATPase essential for chromosome condensation.
Roger Palou, Thillaivillalan Dhanaraman, Rim Marrakchi, Mirela Pascariu, Mike Tyers, Damien D'Amours   +5 more
doaj   +1 more source

Condensins: Organizing and Segregating the Genome [PDF]

Current Biology, 2005
Condensins are multi-subunit protein complexes that play a central role in mitotic chromosome assembly and segregation. The complexes contain 'structural maintenance of chromosomes' (SMC) ATPase subunits, and induce DNA supercoiling and looping in an ATP-hydrolysis-dependent manner in vitro.
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Condensin goes with the family but not with the flow [PDF]

Genome Biology, 2008
Condensin and cohesin are loaded onto yeast chromosomes by a common mechanism at RNA polymerase III transcribed genes. Whereas cohesin translocates from these loading sites to mediate cohesion at secondary locations, condensin remains, bringing distant sites together into clusters.
Gartenberg, MR, Merkenschlager, M
openaire   +3 more sources

Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes [PDF]

Journal of Cell Science, 2007
The assembly of mitotic chromosomes is controlled by condensin complexes. In vertebrates, condensin I binds to chromatin in prometaphase, confers rigidity to chromosomes and enables the release of cohesin complexes from chromosome arms, whereas condensin II associates with chromosomes in prophase and promotes their condensation.
Lipp, J., Hirota, T., Poser, I., Peters, J.   +3 more
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RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes. [PDF]

PLoS Genetics, 2014
Condensin-mediated chromosome condensation is essential for genome stability upon cell division. Genetic studies have indicated that the association of condensin with chromatin is intimately linked to gene transcription, but what transcription-associated
Pénélope Legros, Amélie Malapert, Sho Niinuma, Pascal Bernard, Vincent Vanoosthuyse   +4 more
doaj   +1 more source

The loading of condensin in the context of chromatin

Current Genetics, 2016
The packaging of DNA into chromosomes is a ubiquitous process that enables living organisms to structure and transmit their genome accurately through cell divisions. In the three kingdoms of life, the architecture and dynamics of chromosomes rely upon ring-shaped SMC (Structural Maintenance of Chromosomes) condensin complexes.
Robellet, Xavier, Vanoosthuyse, Vincent, Bernard, Pascal   +2 more
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Plant condensin II is required for the correct spatial relationship between centromeres and rDNA arrays

Nucleus, 2019
Plants possess the structural maintenance of chromosome (SMC) protein complexes cohesin, condensin, and SMC5/6, which function in fundamental biological processes such as sister chromatid cohesion, chromosome condensation and segregation, and damaged DNA
Takuya Sakamoto, Tomoya Sugiyama, Tomoe Yamashita, Sachihiro Matsunaga   +3 more
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Condensin Regulates the Stiffness of Vertebrate Centromeres [PDF]

Molecular Biology of the Cell, 2009
When chromosomes are aligned and bioriented at metaphase, the elastic stretch of centromeric chromatin opposes pulling forces exerted on sister kinetochores by the mitotic spindle. Here we show that condensin ATPase activity is an important regulator of centromere stiffness and function.
Ribeiro, S.A., Gatlin, J.C., Dong, Y., Cameron, L., Hudson, D.F., Farr, C.F., Joglekar, A., McEwen, B.F., Salmon, E.D., Earnshaw, W.C., Vagnarelli, P.   +10 more
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Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. [PDF]

PLoS Genetics, 2014
During development of the cerebral cortex, neural stem cells (NSCs) divide symmetrically to proliferate and asymmetrically to generate neurons. Although faithful segregation of mitotic chromosomes is critical for NSC divisions, its fundamental mechanism ...
Kenji Nishide, Tatsuya Hirano
doaj   +1 more source