Results 21 to 30 of about 6,249 (200)
eLife, 2022 Condensin I is a pentameric protein complex that plays an essential role in mitotic chromosome assembly in eukaryotic cells. Although it has been shown that condensin I loading is mitosis specific, it remains poorly understood how the robust cell cycle ...
Shoji Tane +6 more
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An SMC-like protein binds and regulates Caenorhabditis elegans condensins. [PDF]
PLoS Genetics, 2017 Structural Maintenance of Chromosomes (SMC) family proteins participate in multisubunit complexes that govern chromosome structure and dynamics.
Lucy Fang-I Chao +4 more
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Condensin action and compaction [PDF]
Current Genetics, 2018 Condensin is a multi-subunit protein complex that belongs to the family of structural maintenance of chromosomes (SMC) complexes. Condensins regulate chromosome structure in a wide range of processes including chromosome segregation, gene regulation, DNA repair and recombination.
Matthew Robert Paul +2 more
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Condensins under the microscope [PDF]
Journal of Cell Biology, 2018 Condensins are key players in mitotic chromosome condensation. Using an elegant combination of state-of-the-art imaging techniques, Walther et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201801048) counted the number of Condensins, examined their behaviors on human mitotic chromosomes, and integrated the quantitative data to propose a new ...
Kazuhiro Maeshima +2 more
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Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1. [PDF]
PLoS ONE, 2011 Condensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with PARP1 in response to DNA damage and plays a role in single-strand break repair.
Xiangduo Kong +6 more
doaj +1 more source
Molecular dissection of condensin II-mediated chromosome assembly using in vitro assays
eLife, 2022 In vertebrates, condensin I and condensin II cooperate to assemble rod-shaped chromosomes during mitosis. Although the mechanism of action and regulation of condensin I have been studied extensively, our corresponding knowledge of condensin II remains ...
Makoto M Yoshida +6 more
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Where, When, and How? Integrating Spatiotemporal Cues in Cell Division. [PDF]
BioessaysAccurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Cirillo L +3 more
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Genome Biology, 2020 Background Structural maintenance of chromosomes (SMC) complexes are central organizers of chromatin architecture throughout the cell cycle. The SMC family member condensin is best known for establishing long-range chromatin interactions in mitosis ...
Yasutaka Kakui +7 more
doaj +1 more source
Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts [PDF]
Open Biology, 2019 Condensin is an essential component of chromosome dynamics, including mitotic chromosome condensation and segregation, DNA repair, and development. Genome-wide localization of condensin is known to correlate with transcriptional activity.
Norihiko Nakazawa +2 more
doaj +1 more source
A role for condensin in mediating transcriptional adaptation to environmental stimuli
Life Science Alliance, 2021 Fast conditional depletion of the chromosomal condensin complex from budding yeast cells reveals roles in transcriptional regulation, especially during the establishment of new gene expression patterns.
Lucy Lancaster +3 more
doaj +1 more source