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Condensin‐Condensin Interactions Facilitate Mitotic Chromosome Assembly in Xenopus Egg Extracts [PDF]
Genes to CellsABSTRACT Condensins are large protein complexes that play a central role in mitotic chromosome assembly in eukaryotes. Our previous mutational analyses of condensin I, combined with Xenopus egg cell‐free extracts, provided evidence that dynamic condensin‐condensin ...
Kazuhisa Kinoshita +2 more
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Condensin loop extrusion properties, roadblocks, and role in homology search during recombination in S. cerevisiae [PDF]
The EMBO JournalThe in vivo mechanism, cis-acting roadblocks, and biological functions of DNA loop extrusion by eukaryotic SMC complexes remain incompletely defined. Here, we identify condensin-dependent Hi-C contact stripes at the recombination enhancer (RE) and at ...
Vinciane Piveteau +6 more
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Condensin, Chromatin Crossbarring and Chromosome Condensation [PDF]
Current Biology, 2012 The processes underlying the large-scale reorganisation of chromatin in mitosis that form compact mitotic chromosomes and ensure the fidelity of chromosome segregation during cell division still remain obscure. The chromosomal condensin complex is a major molecular effector of chromosome condensation and segregation in diverse organisms ranging from ...
Thadani, Rahul +2 more
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Roles for Condensin in C. elegans Chromosome Dynamics. [PDF]
, 2011 Condensin complexes are essential for higher order organization of chromosome structure. Higher eukaryotes have two condensins (condensin I and II) dedicated to mitotic and meiotic chromosome dynamics. C. elegans was thought to be an anomaly, with only a
Collette, Karishma S.
core +7 more sources
The length and strength of compartmental interactions are modulated by condensin II activity. [PDF]
PLoS GeneticsThe spatial organization of the genome is crucial for its function and integrity. Although the ring-like SMC complex condensin II has a well-documented role in organizing mitotic chromosomes, its function in interphase chromatin structure has remained ...
Randi Isenhart +7 more
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Condensin action and compaction [PDF]
Current Genetics, 2018 Condensin is a multi-subunit protein complex that belongs to the family of structural maintenance of chromosomes (SMC) complexes. Condensins regulate chromosome structure in a wide range of processes including chromosome segregation, gene regulation, DNA repair and recombination.
Matthew Robert Paul +2 more
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Genome Biology, 2020 Background Structural maintenance of chromosomes (SMC) complexes are central organizers of chromatin architecture throughout the cell cycle. The SMC family member condensin is best known for establishing long-range chromatin interactions in mitosis ...
Yasutaka Kakui +7 more
doaj +1 more source
Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts [PDF]
Open Biology, 2019 Condensin is an essential component of chromosome dynamics, including mitotic chromosome condensation and segregation, DNA repair, and development. Genome-wide localization of condensin is known to correlate with transcriptional activity.
Norihiko Nakazawa +2 more
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A role for condensin in mediating transcriptional adaptation to environmental stimuli
Life Science Alliance, 2021 Fast conditional depletion of the chromosomal condensin complex from budding yeast cells reveals roles in transcriptional regulation, especially during the establishment of new gene expression patterns.
Lucy Lancaster +3 more
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Condensin in Chromatid Cohesion and Segregation [PDF]
Cytogenetic and Genome Research, 2015 After replication of genomic DNA during the S phase, 2 chromatids hold together longitudinally. When cells enter mitosis, the paired sister chromatids start to condense and then segregate into individual chromatids except for the centromeric region. Upon attachment of microtubules to the kinetochore, subsequent pulling of the 2 sister chromatids by the
Susumu, Uchiyama, Kiichi, Fukui
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