Results 21 to 30 of about 4,930 (171)
Genome Biology, 2020 Background Structural maintenance of chromosomes (SMC) complexes are central organizers of chromatin architecture throughout the cell cycle. The SMC family member condensin is best known for establishing long-range chromatin interactions in mitosis ...
Yasutaka Kakui +7 more
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Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts [PDF]
Open Biology, 2019 Condensin is an essential component of chromosome dynamics, including mitotic chromosome condensation and segregation, DNA repair, and development. Genome-wide localization of condensin is known to correlate with transcriptional activity.
Norihiko Nakazawa +2 more
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A role for condensin in mediating transcriptional adaptation to environmental stimuli
Life Science Alliance, 2021 Fast conditional depletion of the chromosomal condensin complex from budding yeast cells reveals roles in transcriptional regulation, especially during the establishment of new gene expression patterns.
Lucy Lancaster +3 more
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Condensin in Chromatid Cohesion and Segregation [PDF]
Cytogenetic and Genome Research, 2015 After replication of genomic DNA during the S phase, 2 chromatids hold together longitudinally. When cells enter mitosis, the paired sister chromatids start to condense and then segregate into individual chromatids except for the centromeric region. Upon attachment of microtubules to the kinetochore, subsequent pulling of the 2 sister chromatids by the
Susumu, Uchiyama, Kiichi, Fukui
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Chromosome Organization: Original Condensins [PDF]
Current Biology, 2014 Two new studies reveal the main actors involved in the resolution and segregation of newly replicated origins in bacteria. These results have important implications for our understanding of the mechanisms involved in precisely coordinating chromosome organization, segregation and replication.
Diego I. Cattoni +2 more
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The expanding territories of condensin II [PDF]
Cell Cycle, 2015 The 3D structure of the eukaryotic genome and its spatial regulation within nuclei are governed by a range of architectural proteins. One class of such factors is the condensins, highly conserved multi-subunit protein complexes. Most eukaryotic species have 2 condensins, condensin I and II, and both condensins are essential for mitotic chromosome ...
Yoko Ito, Masashi Narita
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Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III.
PLoS Genetics, 2023 Despite recent advances in single-molecule and structural analysis of condensin activity in vitro, mechanisms of functional condensin loading and loop extrusion that lead to specific chromosomal organization remain unclear.
Manikarna Dinda +6 more
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Cell Reports, 2020 Summary: Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear.
Rajan Pandey +18 more
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Where, When, and How? Integrating Spatiotemporal Cues in Cell Division. [PDF]
BioessaysAccurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Cirillo L +3 more
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Small Molecule Condensin Inhibitors [PDF]
ACS Infectious Diseases, 2018 Condensins play a unique role in orchestrating the global folding of the chromosome, an essential cellular process, and contribute to human disease and bacterial pathogenicity. As such, they represent an attractive and as yet untapped target for diverse therapeutic interventions.
Hang Zhao +5 more
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