Results 11 to 20 of about 6,725 (195)

Levels of Ycg1 Limit Condensin Function during the Cell Cycle. [PDF]

PLoS Genetics, 2016
During mitosis chromosomes are condensed to facilitate their segregation, through a process mediated by the condensin complex. Although several factors that promote maximal condensin activity during mitosis have been identified, the mechanisms that ...
Tyler W Doughty, Heather E Arsenault, Jennifer A Benanti   +2 more
doaj   +4 more sources

Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes [PDF]

Journal of Cell Science, 2007
The assembly of mitotic chromosomes is controlled by condensin complexes. In vertebrates, condensin I binds to chromatin in prometaphase, confers rigidity to chromosomes and enables the release of cohesin complexes from chromosome arms, whereas condensin II associates with chromosomes in prophase and promotes their condensation.
Lipp, J., Hirota, T., Poser, I., Peters, J.   +3 more
openaire   +4 more sources

Evolutionary Patterns of the Genes Involved in the Integrity and Segregation of Chromosomes in Sawflies (Hymenoptera: Symphyta) [PDF]

Ecology and Evolution, Volume 16, Issue 6, June 2026.
This study identifies and characterizes the genes encoding cohesin and condensin complexes across Symphytan superfamilies, revealing their structural and functional roles with conserved motifs in maintaining genome stability. Phylogenetic analyses indicate that SMC genes originated from ancient duplication events, with notable gene loss (e.g., CAPG2 ...
Ayşe Rümeysa Nalça, Ertan Mahir Korkmaz   +1 more
wiley   +2 more sources

A role for condensin-mediator interaction in mitotic chromosome organization [PDF]

Nature Communications
Condensin organizes eukaryotic genomes into three-dimensional (3D) chromosome architectures that support accurate chromosome segregation during mitosis. However, the molecular mechanisms underlying this organization remain unclear.
Osamu Iwasaki, Sanki Tashiro, Claire Yik-Lok Chung, Tomomi Hayashi, Hideki Tanizawa, Xuebing Wang, Shinya Ohta, Yuko Fujioka, Joseph Han, Gabrielle Tabor, Mikihiro Kawagoe, Ronen Marmorstein, Nobuo N. Noda, Ken-ichi Noma   +13 more
doaj   +2 more sources

Histone Density and Dynamics Shape Mitotic Chromatid Architecture in Xenopus Egg Extracts [PDF]

Genes to Cells, Volume 31, Issue 3, May 2026.
Histone chaperones and chromatin remodelers modulate histone density and dynamics. The resulting local chromatin properties are integrated with DNA reconfiguration activities mediated by condensins and topoisomerase IIα to shape the global architecture of mitotic chromosomes.
Keishi Shintomi, Keita Ohsumi, Mari Iwabuchi, Tatsuya Hirano   +3 more
wiley   +2 more sources

Condensin complexes: from chromatin organization to disease [PDF]

Nucleus
Condensin complexes are indispensable for mitotic chromosome condensation. In this review, we summarize their structural and functional features, focusing on ATP-dependent loop extrusion and mitotic chromatin folding. We discuss current models of mitotic
Lirong Shu, Haoyue Zhang
doaj   +2 more sources

Condensin Regulates the Stiffness of Vertebrate Centromeres [PDF]

Molecular Biology of the Cell, 2009
When chromosomes are aligned and bioriented at metaphase, the elastic stretch of centromeric chromatin opposes pulling forces exerted on sister kinetochores by the mitotic spindle. Here we show that condensin ATPase activity is an important regulator of centromere stiffness and function.
Ribeiro, S.A., Gatlin, J.C., Dong, Y., Cameron, L., Hudson, D.F., Farr, C.F., Joglekar, A., McEwen, B.F., Salmon, E.D., Earnshaw, W.C., Vagnarelli, P.   +10 more
openaire   +5 more sources

Decoding Mitotic Chromosome Assembly: Three Rules Governing Condensin–Cohesin Engagement [PDF]

Research
Mitotic chromosome formation depends on coordinated SMC complex activities, yet how condensin engages cohesin during this process remains unclear. Samejima et al.
Haiyan Yan, Xinyu Zhou, Fangwei Wang
doaj   +2 more sources

A phospho-switch to trigger mitotic chromosome condensation [PDF]

Biology Direct
One of the most eye-catching events in cell biology is the condensation of chromosomes. During mitosis, the diffuse interphase chromatin rearranges into compact, rod-shaped chromosomes that can be precisely segregated between the daughter cells.
Alessandro Borsellini
doaj   +2 more sources

Functional interplay between condensin I and topoisomerase IIα in single-molecule DNA compaction [PDF]

Nature Communications
Condensin I and topoisomerase IIα (topo IIα) are chromosomal ATPases essential for mitotic chromosome assembly. Mechanistically how the two ATPases cooperate to assemble mitotic chromosomes remains unknown.
Yuko Tsubota, Keishi Shintomi, Kazuhisa Kinoshita, Yuki Masahara-Negishi, Yuuki Aizawa, Masami Shima, Tatsuya Hirano, Tomoko Nishiyama   +7 more
doaj   +2 more sources