Results 11 to 20 of about 6,249 (200)

Functional dissection of the Drosophila melanogaster condensin subunit Cap-G reveals its exclusive association with condensin I. [PDF]

PLoS Genetics, 2013
The heteropentameric condensin complexes have been shown to participate in mitotic chromosome condensation and to be required for unperturbed chromatid segregation in nuclear divisions.
Sabine Herzog, Sonal Nagarkar Jaiswal, Evelin Urban, Anna Riemer, Sina Fischer, Stefan K Heidmann   +5 more
doaj   +3 more sources

Levels of Ycg1 Limit Condensin Function during the Cell Cycle. [PDF]

PLoS Genetics, 2016
During mitosis chromosomes are condensed to facilitate their segregation, through a process mediated by the condensin complex. Although several factors that promote maximal condensin activity during mitosis have been identified, the mechanisms that ...
Tyler W Doughty, Heather E Arsenault, Jennifer A Benanti   +2 more
doaj   +4 more sources

Contrasting roles of condensin I and condensin II in mitotic chromosome formation. [PDF]

Journal of cell science, 2013
In vertebrates, two condensin complexes exist, condensin I and condensin II, which have differing but unresolved roles in organizing mitotic chromosomes. To dissect accurately the role of each complex in mitosis, we have made and studied the first vertebrate conditional knockouts of the genes encoding condensin I subunit CAP-H and condensin II subunit ...
Lydia C, Green, Paul, Kalitsis, Tsz M, Chang, Miri, Cipetic, Ji Hun, Kim, Owen, Marshall, Lynne, Turnbull, Cynthia B, Whitchurch, Paola, Vagnarelli, Kumiko, Samejima, William C, Earnshaw, K H Andy, Choo, Damien F, Hudson   +12 more
core   +6 more sources

Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes [PDF]

Journal of Cell Science, 2007
The assembly of mitotic chromosomes is controlled by condensin complexes. In vertebrates, condensin I binds to chromatin in prometaphase, confers rigidity to chromosomes and enables the release of cohesin complexes from chromosome arms, whereas condensin II associates with chromosomes in prophase and promotes their condensation.
Lipp, J., Hirota, T., Poser, I., Peters, J.   +3 more
openaire   +4 more sources

Condensin Regulates the Stiffness of Vertebrate Centromeres [PDF]

Molecular Biology of the Cell, 2009
When chromosomes are aligned and bioriented at metaphase, the elastic stretch of centromeric chromatin opposes pulling forces exerted on sister kinetochores by the mitotic spindle. Here we show that condensin ATPase activity is an important regulator of centromere stiffness and function.
Ribeiro, S.A., Gatlin, J.C., Dong, Y., Cameron, L., Hudson, D.F., Farr, C.F., Joglekar, A., McEwen, B.F., Salmon, E.D., Earnshaw, W.C., Vagnarelli, P.   +10 more
openaire   +5 more sources

Condensin confers the longitudinal rigidity of chromosomes [PDF]

Nature Cell Biology, 2015
In addition to inter-chromatid cohesion, mitotic and meiotic chromatids must have three physical properties: compaction into 'threads' roughly co-linear with their DNA sequence, intra-chromatid cohesion determining their rigidity, and a mechanism to promote sister chromatid disentanglement.
Martin Houlard, Jonathan Godwin, Jean Metson, Jibak Lee, Tatsuya Hirano, Kim Nasmyth   +5 more
openaire   +3 more sources

Condensin: crafting the chromosome landscape

Chromosoma, 2013
The successful transmission of complete genomes from mother to daughter cells during cell divisions requires the structural re-organization of chromosomes into individualized and compact structures that can be segregated by mitotic spindle microtubules. Multi-subunit protein complexes named condensins play a central part in this chromosome condensation
Ilaria, Piazza, Christian H, Haering, Anna, Rutkowska   +2 more
openaire   +3 more sources

Condensin I protects meiotic cohesin from WAPL-1 mediated removal.

PLoS Genetics, 2018
Condensin complexes are key determinants of higher-order chromatin structure and are required for mitotic and meiotic chromosome compaction and segregation.
Margarita R Hernandez, Michael B Davis, Jianhao Jiang, Elizabeth A Brouhard, Aaron F Severson, Györgyi Csankovszki   +5 more
doaj   +2 more sources

Evolutionary Patterns of the Genes Involved in the Integrity and Segregation of Chromosomes in Sawflies (Hymenoptera: Symphyta). [PDF]

Ecol Evol
This study identifies and characterizes the genes encoding cohesin and condensin complexes across Symphytan superfamilies, revealing their structural and functional roles with conserved motifs in maintaining genome stability. Phylogenetic analyses indicate that SMC genes originated from ancient duplication events, with notable gene loss (e.g., CAPG2 ...
Nalça AR, Korkmaz EM.
europepmc   +2 more sources

Histone Density and Dynamics Shape Mitotic Chromatid Architecture in Xenopus Egg Extracts. [PDF]

Genes Cells
Histone chaperones and chromatin remodelers modulate histone density and dynamics. The resulting local chromatin properties are integrated with DNA reconfiguration activities mediated by condensins and topoisomerase IIα to shape the global architecture of mitotic chromosomes.
Shintomi K, Ohsumi K, Iwabuchi M, Hirano T.   +3 more
europepmc   +2 more sources