Condensin I but not Condensin II is crucial for mitotic chromosome mechanics
Nature CommunicationsDuring mitotic cell division, pliable interphase chromatin is transformed into stiff mitotic chromosomes able to withstand the pushing and pulling forces of the mitotic spindle.
Christian F. Nielsen +10 more
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Evolutionary Patterns of the Genes Involved in the Integrity and Segregation of Chromosomes in Sawflies (Hymenoptera: Symphyta). [PDF]
Ecol EvolThis study identifies and characterizes the genes encoding cohesin and condensin complexes across Symphytan superfamilies, revealing their structural and functional roles with conserved motifs in maintaining genome stability. Phylogenetic analyses indicate that SMC genes originated from ancient duplication events, with notable gene loss (e.g., CAPG2 ...
Nalça AR, Korkmaz EM.
europepmc +2 more sources
Histone Density and Dynamics Shape Mitotic Chromatid Architecture in Xenopus Egg Extracts. [PDF]
Genes CellsHistone chaperones and chromatin remodelers modulate histone density and dynamics. The resulting local chromatin properties are integrated with DNA reconfiguration activities mediated by condensins and topoisomerase IIα to shape the global architecture of mitotic chromosomes.
Shintomi K +3 more
europepmc +2 more sources
Functional dissection of the Drosophila melanogaster condensin subunit Cap-G reveals its exclusive association with condensin I. [PDF]
PLoS Genetics, 2013 The heteropentameric condensin complexes have been shown to participate in mitotic chromosome condensation and to be required for unperturbed chromatid segregation in nuclear divisions.
Sabine Herzog +5 more
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An SMC-like protein binds and regulates Caenorhabditis elegans condensins. [PDF]
PLoS Genetics, 2017 Structural Maintenance of Chromosomes (SMC) family proteins participate in multisubunit complexes that govern chromosome structure and dynamics.
Lucy Fang-I Chao +4 more
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Condensin action and compaction [PDF]
Current Genetics, 2018 Condensin is a multi-subunit protein complex that belongs to the family of structural maintenance of chromosomes (SMC) complexes. Condensins regulate chromosome structure in a wide range of processes including chromosome segregation, gene regulation, DNA repair and recombination.
Matthew Robert Paul +2 more
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Condensins under the microscope [PDF]
Journal of Cell Biology, 2018 Condensins are key players in mitotic chromosome condensation. Using an elegant combination of state-of-the-art imaging techniques, Walther et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201801048) counted the number of Condensins, examined their behaviors on human mitotic chromosomes, and integrated the quantitative data to propose a new ...
Kazuhiro Maeshima +2 more
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Levels of Ycg1 Limit Condensin Function during the Cell Cycle. [PDF]
PLoS Genetics, 2016 During mitosis chromosomes are condensed to facilitate their segregation, through a process mediated by the condensin complex. Although several factors that promote maximal condensin activity during mitosis have been identified, the mechanisms that ...
Tyler W Doughty +2 more
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Molecular dissection of condensin II-mediated chromosome assembly using in vitro assays
eLife, 2022 In vertebrates, condensin I and condensin II cooperate to assemble rod-shaped chromosomes during mitosis. Although the mechanism of action and regulation of condensin I have been studied extensively, our corresponding knowledge of condensin II remains ...
Makoto M Yoshida +6 more
doaj +1 more source
Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1. [PDF]
PLoS ONE, 2011 Condensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with PARP1 in response to DNA damage and plays a role in single-strand break repair.
Xiangduo Kong +6 more
doaj +1 more source