Results 61 to 70 of about 4,930 (171)
Factors Determining Sirtuin‐1 Target Engagement
Advanced Biology, Volume 10, Issue 7, July 2026.ABSTRACT Sirtuin‐1 (Sirt1) is a key NAD+‐dependent deacylase regulating metabolism, stress responses, genome stability, and aging. Although well‐characterized biochemically and structurally, its substrate selectivity remains unclear: in vitro, Sirt1 appears promiscuous, while in vivo it activates particular processes in response to different stimuli ...
Petra Neumann‐Staubitz +3 more
wiley +1 more source
eLife, 2018 Condensins are genome organisers that shape chromosomes and promote their accurate transmission. Several studies have also implicated condensins in gene expression, although any mechanisms have remained enigmatic. Here, we report on the role of condensin
Clémence Hocquet +11 more
doaj +1 more source
Clinical Case Reports, Volume 14, Issue 7, July 2026.Serial sagittal T1‐weighted MR images demonstrating persistent thinning of the corpus callosum. (A) Initial MRI at 19 months of age shows diffuse thinning of the corpus callosum involving the body and splenium. (B) Follow‐up MRI one year later demonstrates stable appearance without interval progression, consistent with corpus callosal hypoplasia ...
Anwar Abu Hetta +4 more
wiley +1 more source
Cti1/C1D interacts with condensin SMC hinge and supports the DNA repair function of condensin [PDF]
Proceedings of the National Academy of Sciences, 2004 Condensin is a conserved five-subunit complex containing two SMC (structural maintenance of chromosomes) and three non-SMC subunits and plays a major role in mitotic chromosome condensation. Condensin also acts in interphase and is required for DNA repair and replication checkpoint control. We attempted to study the function of the condensin in greater
Ee Sin, Chen +2 more
openaire +2 more sources
Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking
Mass Spectrometry Reviews, Volume 45, Issue 4, Page 644-671, July/August 2026.ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu +4 more
wiley +1 more source
Condensin function in dosage compensation [PDF]
Epigenetics, 2009 Dosage compensation is an essential process that equalizes X-linked gene dosage between the sexes. In the worm Caenorhabditis elegans, a complex of proteins called the dosage compensation complex (DCC) binds both X chromosomes in hermaphrodites to downregulate gene expression two-fold and hence to reduce X-linked gene expression levels equal to that in
openaire +2 more sources
TTK Overexpression: A Negative Prognostic Biomarker in Anaplastic Thyroid Carcinoma
Cancer Medicine, Volume 15, Issue 6, June 2026.ABSTRACT Background Given threonine and tyrosine kinase (TTK)'s oncogenic role in various cancers and its understudied status in thyroid cancer, this study investigates TTK expression in thyroid lesions to assess its diagnostic and therapeutic potential. Methods We analyzed differential TTK expression levels using public datasets (n = 143) and clinical
Yan Guo +7 more
wiley +1 more source
Cell cycle regulation of condensin Smc4 [PDF]
Oncotarget, 2019 The condensin complex is a conserved ATPase which promotes the compaction of chromatin during mitosis in eukaryotic cells. Condensin complexes have in addition been reported to contribute to interphase processes including sister chromatid cohesion. It is not understood how condensins specifically become competent to facilitate chromosome condensation ...
Wei-Shan, Hsu +2 more
openaire +2 more sources
Metaphase chromosome structure is dynamically maintained by condensin I-directed DNA (de)catenation
eLife, 2017 Mitotic chromosome assembly remains a big mystery in biology. Condensin complexes are pivotal for chromosome architecture yet how they shape mitotic chromatin remains unknown.
Ewa Piskadlo +2 more
doaj +1 more source
Three-dimensional topology of the SMC2/SMC4 subcomplex from chicken condensin I revealed by cross-linking and molecular modelling [PDF]
Open Biology, 2015 SMC proteins are essential components of three protein complexes that are important for chromosome structure and function. The cohesin complex holds replicated sister chromatids together, whereas the condensin complex has an essential role in mitotic ...
Helena Barysz +6 more
doaj +1 more source