Results 61 to 70 of about 6,725 (195)
Nucleus, 2019 Plants possess the structural maintenance of chromosome (SMC) protein complexes cohesin, condensin, and SMC5/6, which function in fundamental biological processes such as sister chromatid cohesion, chromosome condensation and segregation, and damaged DNA
Takuya Sakamoto +3 more
doaj +1 more source
Condensins are Required for Maintenance of Nuclear Architecture [PDF]
Cells, 2014 The 3-dimensional spatial organization of eukaryotic genomes is important for regulation of gene expression as well as DNA damage repair. It has been proposed that one basic biophysical property of all nuclei is that interphase chromatin must be kept in a condensed prestressed state in order to prevent entropic pressure of the DNA polymer from ...
George, Carolyn +3 more
openaire +3 more sources
The loading of condensin in the context of chromatin
Current Genetics, 2016 The packaging of DNA into chromosomes is a ubiquitous process that enables living organisms to structure and transmit their genome accurately through cell divisions. In the three kingdoms of life, the architecture and dynamics of chromosomes rely upon ring-shaped SMC (Structural Maintenance of Chromosomes) condensin complexes.
Robellet, Xavier +2 more
openaire +3 more sources
Dangerous liaisons: MYCN meets condensins [PDF]
Cell Cycle, 2014 (2014). Dangerous liaisons: MYCN meets condensins. Cell Cycle: Vol. 13, No. 8, pp. 1225-1226.
Y. J. Achar, M. Foiani
openaire +3 more sources
Three Distinct Condensin Complexes Control C. elegans Chromosome Dynamics [PDF]
, 2009 SummaryBackgroundCondensin complexes organize chromosome structure and facilitate chromosome segregation. Higher eukaryotes have two complexes, condensin I and condensin II, each essential for chromosome segregation.
Tabuchi, Tomoko +16 more
core +1 more source
Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. [PDF]
PLoS Genetics, 2014 During development of the cerebral cortex, neural stem cells (NSCs) divide symmetrically to proliferate and asymmetrically to generate neurons. Although faithful segregation of mitotic chromosomes is critical for NSC divisions, its fundamental mechanism ...
Kenji Nishide, Tatsuya Hirano
doaj +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto +5 more
wiley +1 more source
The molecular mechanism of condensin in mitotic chromosome formation [PDF]
, 2022 The rearrangement of interphase chromatin into mitotic chromosomes is crucial for faithful chromosome segregation. Defects in this process may cause chromosome entanglement, decompaction, chromosome bridges during anaphase, and eventually genome ...
Tang, Minzhe
core +1 more source
Cell Reports, 2014 Condensin is a central regulator of mitotic genome structure with mutants showing poorly condensed chromosomes and profound segregation defects. Here, we identify NCT, a complex comprising the Nrc1 BET-family tandem bromodomain protein (SPAC631.02 ...
Hyun-Soo Kim +18 more
doaj +1 more source
RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes
Life Science Alliance, 2021 Using both experiments and mathematical modelling, the authors show that RNA polymerase backtracking contributes to the accumulation of condensin in the termination zone of active genes.
Julieta Rivosecchi +5 more
doaj +1 more source