Results 81 to 90 of about 7,152 (199)

Situs Inversus Totalis and Severe Early‐Onset Developmental Epileptic Encephalopathy in a Child With a Homozygous CFAP52 Mutation: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
Serial sagittal T1‐weighted MR images demonstrating persistent thinning of the corpus callosum. (A) Initial MRI at 19 months of age shows diffuse thinning of the corpus callosum involving the body and splenium. (B) Follow‐up MRI one year later demonstrates stable appearance without interval progression, consistent with corpus callosal hypoplasia ...
Anwar Abu Hetta, Lina Abughaboosh, Jenan Al‐Qasrawi, Balqees Amro, Mayar Alshaer   +4 more
wiley   +1 more source

Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription

eLife, 2018
Condensins are genome organisers that shape chromosomes and promote their accurate transmission. Several studies have also implicated condensins in gene expression, although any mechanisms have remained enigmatic. Here, we report on the role of condensin
Clémence Hocquet, Xavier Robellet, Laurent Modolo, Xi-Ming Sun, Claire Burny, Sara Cuylen-Haering, Esther Toselli, Sandra Clauder-Münster, Lars Steinmetz, Christian H Haering, Samuel Marguerat, Pascal Bernard   +11 more
doaj   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 644-671, July/August 2026.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

The role of condensin in chromosome resolution [PDF]

, 2012
The condensin complex is a key determinant of mitotic chromosome architecture. In addition to its role in mitotic chromosome compaction, condensin is required for resolution of sister chromatid linkages during chromosome segregation in anaphase.
Charbin, AA
core  

Plk1 phosphorylation of CAP-H2 triggers chromosome condensation by condensin II at the early phase of mitosis

Scientific Reports, 2017
Condensin complexes play crucial roles in chromosome condensation that is a fundamental process to establish the “rod-like” shape of chromosome structure in mitosis.
Yuya Kagami, Masaya Ono, Kiyotsugu Yoshida   +2 more
doaj   +1 more source

Identification of a BET Family Bromodomain/Casein Kinase II/TAF-Containing Complex as a Regulator of Mitotic Condensin Function

Cell Reports, 2014
Condensin is a central regulator of mitotic genome structure with mutants showing poorly condensed chromosomes and profound segregation defects. Here, we identify NCT, a complex comprising the Nrc1 BET-family tandem bromodomain protein (SPAC631.02 ...
Hyun-Soo Kim, Rituparna Mukhopadhyay, Scott B. Rothbart, Andrea C. Silva, Vincent Vanoosthuyse, Ernest Radovani, Thomas Kislinger, Assen Roguev, Colm J. Ryan, Jiewei Xu, Harlizawati Jahari, Kevin G. Hardwick, Jack F. Greenblatt, Nevan J. Krogan, Jeffrey S. Fillingham, Brian D. Strahl, Eric E. Bouhassira, Winfried Edelmann, Michael-Christopher Keogh   +18 more
doaj   +1 more source

TTK Overexpression: A Negative Prognostic Biomarker in Anaplastic Thyroid Carcinoma

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Given threonine and tyrosine kinase (TTK)'s oncogenic role in various cancers and its understudied status in thyroid cancer, this study investigates TTK expression in thyroid lesions to assess its diagnostic and therapeutic potential. Methods We analyzed differential TTK expression levels using public datasets (n = 143) and clinical
Yan Guo, Zhidong Sun, Xiao Liu, Xianni Liu, Haiwen Chen, Menglan Zhang, Weibo Mao, Yuan Cao   +7 more
wiley   +1 more source

Multiple roles of Condensins: a complex story [PDF]

Biology of the Cell, 2004
Summry— Condensins are pentameric complexes that were initially described as being involved in the dynamics of chromosomes during mitosis. It has been recently established that two related complexes (Condensin I and Condensin II) contribute to this process.
Legagneux, Vincent, Cubizolles, Fabien, Watrin, Erwan   +2 more
openaire   +2 more sources

Structural Studies of DNA-bound Condensin [PDF]

Eukaryotic chromosomes undergo massive three-dimensional rearrangements over the course of the cell cycle. Prior to cell division, chromosomes are condensed into rod-shaped structures which ensures the faithful transmission of the genetic material into ...
Lecomte, Léa Candice Lucie
core   +1 more source

RNAP II antagonizes mitotic chromatin folding and chromosome segregation by condensin

Cell Reports
Summary: Condensin shapes mitotic chromosomes by folding chromatin into loops, but whether it does so by DNA-loop extrusion remains speculative. Although loop-extruding cohesin is stalled by transcription, the impact of transcription on condensin, which ...
Jérémy Lebreton, Léonard Colin, Elodie Chatre, Pascal Bernard   +3 more
doaj   +1 more source