Results 81 to 90 of about 6,249 (200)

Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast

, 2020
The eukaryotic genome consists of DNA molecules far longer than the cells that contain them. They reach their greatest compaction during chromosome condensation in mitosis. This process is aided by condensin, a structural maintenance of chromosomes (SMC)
David J Barry (8320179), Yasutaka Kakui (8961683), Adam Rabinowitz (9260519), Frank Uhlmann (54006)   +3 more
core  

Real-time detection of single-molecule DNA compaction by condensin I

, 2004
BACKGROUND: Condensin is thought to contribute to large-scale DNA compaction during mitotic chromosome assembly. It remains unknown, however, how the complex reconfigures DNA structure at a mechanistic level.
Terence R Strick, Kawaguchi, T., Strick, Terence R, Tatsuya Hirano, Tatsuhiko Kawaguchi, Hirano, Tatsuya, Strick, T. R., Hirano, T., Kawaguchi, Tatsuhiko   +8 more
core   +1 more source

Three-dimensional topology of the SMC2/SMC4 subcomplex from chicken condensin I revealed by cross-linking and molecular modelling [PDF]

Open Biology, 2015
SMC proteins are essential components of three protein complexes that are important for chromosome structure and function. The cohesin complex holds replicated sister chromatids together, whereas the condensin complex has an essential role in mitotic ...
Helena Barysz, Ji Hun Kim, Zhuo Angel Chen, Damien F. Hudson, Juri Rappsilber, Dietlind L. Gerloff, William C. Earnshaw   +6 more
doaj   +1 more source

Investigating Phase Separation in Genome Folding via Multiscale Computational Modeling

Advanced Science, Volume 13, Issue 24, 27 April 2026.
Phase separation is emerging as a multiscale organizing principle of genome folding across scales, from nucleosomes and transcriptional condensates to chromatin domains and nuclear compartments. By integrating physics‐based simulations with data‐driven inference, computational modeling now links molecular interactions to nuclear architecture and points
Jiahu Tang, Cibo Feng, Haibin Su, Xiakun Chu   +3 more
wiley   +1 more source

Structural Studies of DNA-bound Condensin [PDF]

Eukaryotic chromosomes undergo massive three-dimensional rearrangements over the course of the cell cycle. Prior to cell division, chromosomes are condensed into rod-shaped structures which ensures the faithful transmission of the genetic material into ...
Lecomte, Léa Candice Lucie
core   +1 more source

Structural Basis of the Membrane Association by the Conserved RocS Membrane‐Targeting Sequence in Streptococcus

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Chromosome segregation in Streptococcus pneumoniae depends on RocS, a bitopic protein whose membrane‐anchoring mechanisms were unclear. Using NMR and AFM, this study reveals that the widely conserved RocS anchor binds to membranes via a conserved kink‐helix motif which inserts into lipid nanodomains.
Ana Álvarez‐Mena, Estelle Morvan, Clara Lambert, Anagha Kallisseri Parambil, Martin Lefeuvre, Zeren Xu, Nadia El Mammeri, Florian Malard, Erick J. Dufourc, Cécile Feuillie, Christophe Grangeasse, Birgit Habenstein   +11 more
wiley   +1 more source

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells. [PDF]

PLoS Genetics, 2017
LINE-1 (L1) retrotransposons can mobilize (retrotranspose) within the human genome, and mutagenic de novo L1 insertions can lead to human diseases, including cancers. As a result, cells are actively engaged in preventing L1 retrotransposition.
Jacqueline R Ward, Kommireddy Vasu, Emily Deutschman, Dalia Halawani, Peter A Larson, Dongmei Zhang, Belinda Willard, Paul L Fox, John V Moran, Michelle S Longworth   +9 more
doaj   +1 more source

The interaction between KIF4A and condensin I.

, 2018
(A) HeLa cells expressing EGFP-KIF4A WT or S1186 were arrested at mitosis and the KIF4A-condensin I complex was recovered by immunoprecipitation against GFP and SMC2.
Kiichi Fukui (2036467), Hideaki Takata (468699), Marliza Madung (6111434), Kaoru Katoh (6111437)   +3 more
core   +1 more source

Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing [PDF]

Open Biology, 2011
Condensin is required for chromosome dynamics and diverse DNA metabolism. How condensin works, however, is not well understood. Condensin contains two structural maintenance of chromosomes (SMC) subunits with the terminal globular domains connected to ...
Yuko Akai, Yumiko Kurokawa, Norihiko Nakazawa, Yuko Tonami-Murakami, Yuki Suzuki, Shige H. Yoshimura, Hiroshi Iwasaki, Yoshiharu Shiroiwa, Takahiro Nakamura, Eri Shibata, Mitsuhiro Yanagida   +10 more
doaj   +1 more source